Výsledky vyhledávání - "Klára Gyires"

Akademický článek

Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats

Autor: Szilvia B. László, Barbara Hutka, András S. Tóth, Tamás Hegyes, Zsuzsanna O. Demeter, Arezoo Haghighi, Gerda Wachtl, Ágnes Kelemen, Anna Jakab, Klára Gyires, Zoltán S. Zádori

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

IntroductionIntestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a

Externí odkaz: https://doaj.org/article/38ca252b9d8b41409a2cca7959d1ff8e

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Akademický článek

The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat

Autor: Barbara Hutka, Bernadette Lázár, András S. Tóth, Bence Ágg, Szilvia B. László, Nóra Makra, Balázs Ligeti, Bálint Scheich, Kornél Király, Mahmoud Al-Khrasani, Dóra Szabó, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce significant damage to the small intestine, which is accompanied by changes in intestinal bacteria (dysbiosis) and bile acids. However, it is still a question of debate whether besides m

Externí odkaz: https://doaj.org/article/1b112fe01fa54c8a8ede6f8bf82c1b1e

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Akademický článek

Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats

Autor: Mihály Balogh, Ferenc Zádor, Zoltán S. Zádori, Mohammed Shaqura, Kornél Király, Amir Mohammadzadeh, Bence Varga, Bernadette Lázár, Shaaban A. Mousa, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Klára Gyires, Michael Schäfer, Susanna Fürst, Mahmoud Al-Khrasani

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Reduction of the opioid analgesia in diabetic neuropathic pain (DNP) results from μ-opioid receptor (MOR) reserve reduction. Herein, we examined the antinociceptive and antiallodynic actions of a novel opioid agonist 14-O-methymorphine-6-O-sulfate (

Externí odkaz: https://doaj.org/article/8ef4a19c62184f1f8a16a5053b0dcdba

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Akademický článek

Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat

Publikováno v: Cells, Vol 8, Iss 3, p 251 (2019)

Intestinal dysbiosis is linked to numerous gastrointestinal disorders, including inflammatory bowel diseases. It is a question of debate if coxibs, selective inhibitors of cyclooxygenase (COX)-2, cause dysbiosis. Therefore, in the present study, we a

Externí odkaz: https://doaj.org/article/447f416e8ec148d5adc5ca8abc2b227f

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Brain-gut axis: From the conditioned reflex to the microbiota-gut-brain communication system

Autor: Klára Gyires

Publikováno v: Интегративная физиология, Vol 1, Iss 4 (2020)

Communication between the central nervous system (CNS) and the gastrointestinal tract is called the brain-gut axis. This communication network includes the CNS, hypothalamic-pituitary-adrenal axis, the autonomic nervous system (sympathetic and parasy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d716fa650bd7452ef44b05a3f6f8e7fd
https://doi.org/10.33910/2687-1270-2020-1-4-266-276

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A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine

Publikováno v: Biochemical pharmacology. 190

It has been proposed that changes in microbiota due to nonsteroidal anti-inflammatory drugs (NSAIDs) alter the composition of bile, and elevation of hydrophobic secondary bile acids contributes to small intestinal damage. However, little is known abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd0d048302109780fe3ab3b6bb36263
https://pubmed.ncbi.nlm.nih.gov/33940029

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Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

Publikováno v: Biochemical Pharmacology

There is some recent evidence that cardiac ischemia/reperfusion (I/R) injury induces intestinal damage within days, which contributes to adverse cardiovascular outcomes after myocardial infarction. However, it is not clear whether remote gut injury h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751335a3667842fc663b8b3ded16d46a

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Autor: Bernadette Lázár, Sz. B. László, Klára Gyires, Zoltán S. Zádori

Publikováno v: Current Pharmaceutical Design. 24:1936-1946

Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e74ab6f5270fab3b881d29a692bd398
https://doi.org/10.2174/1381612824666180516101531

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