Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Klára Grantz Šašková"'
Autor:
Monika Nedomova, Stefanie Haberecht-Müller, Sophie Möller, Simone Venz, Michaela Prochazkova, Jan Prochazka, Frantisek Sedlak, Kallayanee Chawengsaksophak, Elke Hammer, Petr Kasparek, Michael Adamek, Radislav Sedlacek, Jan Konvalinka, Elke Krüger, Klara Grantz Saskova
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110893- (2024)
Summary: DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining proteostasis in mammalian cells, enabling the expression of
Externí odkaz:
https://doaj.org/article/8fa378f6b0684b9892e996b65ed983a4
Autor:
Klára Grantz-Šašková, Ladislav Benda, Jan Konvalinka, Pavel Srb, Václav Šícha, Jiří Brynda, Michal Svoboda, Bohumír Grüner, Martin Lepšík, Ján Tarábek, Vaclav Veverka, Pavlína Řezáčová
Publikováno v:
Physical Chemistry Chemical Physics. 21:5661-5673
Transient and fuzzy intermolecular interactions are fundamental to many biological processes. Despite their importance, they are notoriously challenging to characterize. Effects induced by paramagnetic ligands in the NMR spectra of interacting biomol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac43ba1f6c081a0683b03e6d28470d7
https://doi.org/10.1039/c9cp00416e
https://doi.org/10.1039/c9cp00416e
Publikováno v:
Cancers
Cancers; Volume 12; Issue 5; Pages: 1065
Cancers, Vol 12, Iss 1065, p 1065 (2020)
Cancers; Volume 12; Issue 5; Pages: 1065
Cancers, Vol 12, Iss 1065, p 1065 (2020)
Proteasome inhibitors are the backbone of multiple myeloma therapy. However, disease progression or early relapse occur due to development of resistance to the therapy. One important cause of resistance to proteasome inhibition is the so-called bounc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b159273cfa1a7bc556986099b6d165
http://europepmc.org/articles/PMC7281108
http://europepmc.org/articles/PMC7281108
Autor:
Juanma Ramirez, José L. Martínez-Hernández, Nagore Elu, Michaela Prochazkova, Monika Sivá, Nerea Osinalde, Ugo Mayor, Jesus M. Arizmendi, Kerman Aloria, Coralia Pérez, Rosa Barrio, Klára Grantz Šašková, Benoit Lectez
Publikováno v:
Human Molecular Genetics. 27:1955-1971
Angelman syndrome is a complex neurodevelopmental disorder caused by the lack of function in the brain of a single gene, UBE3A. The E3 ligase coded by this gene is known to build K48-linked ubiquitin chains, a modification historically considered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0add8fb655ec6f1e7b4ec31010b9d96e
https://doi.org/10.1093/hmg/ddy103
https://doi.org/10.1093/hmg/ddy103
Autor:
Jan Konvalinka, Tomáš Cihlář, Dorien de Jong, Kirsten M. Stray, Jiří Brynda, Noortje M van Maarseveen, Milan Kožíšek, Pavlína Řezáčová, Monique Nijhuis, Klára Grantz Šašková
Publikováno v:
Journal of Virology. 88:3586-3590
Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ba262e3a3a6bcd9e4f345c7962320d
https://doi.org/10.1128/jvi.02688-13
https://doi.org/10.1128/jvi.02688-13
Autor:
Klára Grantz Šašková, Martin Lepšík, Pavlína Řezáčová, Jan Konvalinka, Milan Kožíšek, Jiří Brynda
Publikováno v:
FEBS Journal. 281:1834-1847
We report enzymologic, thermodynamic and structural analyses of a series of six clinically derived mutant HIV proteases (PR) resistant to darunavir. As many as 20 mutations in the resistant PRs decreased the binding affinity of darunavir by up to 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61ee8005563acba596c3f49c614ba04
https://doi.org/10.1111/febs.12743
https://doi.org/10.1111/febs.12743
Autor:
Jean-François Trempe, Kay Hofmann, Pavel Šácha, Iva Flaisigová, Rozálie Hexnerová, Klára Grantz Šašková, Jiří Brynda, Jan Konvalinka, Michal Svoboda, Jan Belza, Monika Sivá, Milan Kožíšek, Jana Starková, Martin Hubálek, Vaclav Veverka, Frantisek Sedlak
Publikováno v:
Scientific Reports
Although Ddi1-like proteins are conserved among eukaryotes, their biological functions remain poorly characterized. Yeast Ddi1 has been implicated in cell cycle regulation, DNA-damage response and exocytosis. By virtue of its ubiquitin-like (UBL) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eedbca60c89e274579d3f6ad5426ab
http://europepmc.org/articles/PMC4962041
http://europepmc.org/articles/PMC4962041
Autor:
Jan Konvalinka, Jana Pokorná, Bohumír Grüner, Jaromír Plešek, Pavlina Rezacova, Heike Oberwinkler, Klára Grantz Šašková, Václav Šícha, Petr Cigler, Vladimír Král, Pavel Hobza, Hans-Georg Kräusslich, Martin Lepšík, Jindrich Fanfrlík, Juraj Sedlacek, Irena Sieglová, Milan Kozisek, Jan Rezac, Jiri Brynda
Publikováno v:
Journal of Medicinal Chemistry. 52:7132-7141
HIV protease (HIV PR) is a primary target for anti-HIV drug design. We have previously identified and characterized substituted metallacarboranes as a new class of HIV protease inhibitors. In a structure-guided drug design effort, we connected the tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7caec979b1cc75b93e5985060eb0285
https://doi.org/10.1021/jm9011388
https://doi.org/10.1021/jm9011388
Autor:
Lukáš Žídek, Milan Kožíšek, Klára Grantz Šašková, Vladimír Sklenář, Martin Švec, Monika Kubíčková, Veronika Motáčková
Publikováno v:
Biomolecular NMR Assignments. 3:261-264
Proteases play a crucial role in the retroviral infection but so far the mechanism of their regulation remains unclear. Protease MIA-14 from murine intracisternal A-type particles, containing a C-terminal domain rich in glycines (G-patch), is respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c619932343292654a4bb435f9c580a0
https://doi.org/10.1007/s12104-009-9189-x
https://doi.org/10.1007/s12104-009-9189-x
Autor:
Pavlina Rezacova, Jan Konvalinka, Ron M. Kagan, Tatyana Yashina, Jiri Brynda, Milan Kozisek, Klára Grantz Šašková
Publikováno v:
Journal of Virology. 83:8810-8818
Darunavir is the most recently approved human immunodeficiency virus (HIV) protease (PR) inhibitor (PI) and is active against many HIV type 1 PR variants resistant to earlier-generation PIs. Darunavir shows a high genetic barrier to resistance develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8239b6273177ca292375b28fe98fec0e
https://doi.org/10.1128/jvi.00451-09
https://doi.org/10.1128/jvi.00451-09