Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden

Autor: Musso, M, Westervelt, HJ, Long, JD, Morgan, E, Woods, SP, Smith, MM, Lu, W, Paulsen, JS, Cross, S, Ryan, P, Epping, EA, Chiu, E, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Ross, CA, Varvaris, M, Yoritomo, N, Mallonee, WM, Suter, G, Samii, A, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Barker, RA, Mason, S, Guzman, NV, McCusker, E, Griffith, J, Loy, C, Gunn, D, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Karmalkar, I, Perlman, S, Clemente, B, Geschwind, MD, Sha, S, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, P, Lee, J, Tedesco, M, Maxwell, B, Perlmutter, J, Barton, S, Smith, S, Miedzybrodzka, Z, Rae, D, D'Alessandro, M, Craufurd, D, Bek, J, Howard, E, Mazzoni, P, Marder, K, Wasserman, P, Kumar, R, Erickson, D, Nickels, B, Wheelock, V, Kjer, L, Martin, A, Farias, S, Suchowersky, O, Martin, W, King, P, Wieler, M, Sran, S, Ahmed, A, Rao, S, Reece, C

Publikováno v: Musso, M; Westervelt, HJ; Long, JD; Morgan, E; Woods, SP; Smith, MM; et al.(2015). Intra-individual variability in prodromal Huntington disease and its relationship to genetic burden. Journal of the International Neuropsychological Society, 21(1), 8-21. doi: 10.1017/S1355617714001076. UCSF: Retrieved from: http://www.escholarship.org/uc/item/64s52036

© INS. The International Neuropsychological Society 2015. The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d23dd8c8fac0e24327ed3d3840ecf159
http://www.escholarship.org/uc/item/64s52036

Prefrontal cortex white matter tracts in prodromal Huntington disease

Autor: Matsui, JT, Vaidya, JG, Wassermann, D, Kim, RE, Magnotta, VA, Johnson, HJ, Paulsen, JS, Isabella De Soriano, Shadrick, C, Miller, A, Edmond Chiu, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Lynn Raymond, Decolongon, J, Fan, M, Coleman, A, Christopher, AR, Varvaris, M, Ong, M, Yoritomo, N, Mallonee, WM, Suter, G, Samii, A, Freney, EP, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Barker, RA, Mason, S, Guzman, NV, McCusker, E, Griffith, J, Loy, C, McMillan, J, Gunn, D, Orth, M, Sübmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Law, A, Karmalkar, I, Perlman, S, Clemente, B, Geschwind, MD, Sha, S, Winer, J, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, P, Lee, J, Tedesco, M, Maxwell, B, Perlmutter, J, Barton, S, Smith, S, Miedzybrodzka, Z, Rae, D, Vaughan, V, D'Alessandro, M, Craufurd, D, Bek, J, Howard, E, Mazzoni, P, Marder, K, Wasserman, P, Kumar, R, Erickson, D, Reeves, C, Nickels, B, Wheelock, V, Kjer, L, Martin, A

Publikováno v: Matsui, JT; Vaidya, JG; Wassermann, D; Kim, RE; Magnotta, VA; Johnson, HJ; et al.(2015). Prefrontal cortex white matter tracts in prodromal Huntington disease. Human Brain Mapping, 36(10), 3717-3732. doi: 10.1002/hbm.22835. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3dg2h93m

© 2015 Wiley Periodicals, Inc. Huntington disease (HD) is most widely known for its selective degeneration of striatal neurons but there is also growing evidence for white matter (WM) deterioration. The primary objective of this research was to cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d502ca7b136af3c9215810e454eb1029
http://www.escholarship.org/uc/item/3dg2h93m

Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study

Autor: Paulsen, J. S., Johnson, H. J., Aylward, E. H., Ross, C. A., Williams, J. K., Nance, M. A., Erwin, C. J., Westervelt, H. J., Harrington, D. L., Bockholt, H. J., Zhang, Y., McCusker, E. A., Chiu, E. M., Panegyres, P. K., Cross, S., Ryan, P., Epping, E. A., Preston, J., Goh, A., Antonopoulos, S., Loi, S., Raymond, L., Decolongon, J., Fan, M., Coleman, A., Mallone, W. M., Suter, G., Varvaris, M., Yoritomo, N., Griffith, J., Loy, C., Gunn, D., Guttman, M., Sheinberg, A., Law, A., Quaid, K., Wesson, M., Wojcieszek, J., Perlmutter, J., Barton, S., Smith, S., Barker, R. A., Mason, S., Guzman, N. V., Perlman, S., Clemente, B., Jones, R., Wood-Siverio, C., Factor, S. A., Samii, A., Macaraeg, A., Lee, J., Tedesco, M., Maxwell, B., Kumar, R., Erickson, D., Nickels, B., Marshall, F., Chesire, A., Wodarski, M., Hickey, C., Geschwind, M. D., Sha, S., Satris, G., Ahmed, A., Reece, C., Bura, A., Mourany, L., Pillai, J., Mazzoni, P., Marder, K., Wasserman, P., Craufurd, D., Bek, J., Howard, E., Warner, T., Burrows, M., Orth, M., Süßmuth, S., Barth, K., Trautmann, S., Schwenk, D., Eschenbach, C., Wheelock, V., Kjer, L., Martin, A., Farias, S., Miedzybrodzka, Z., Rae, D., D'Alessandro, M., Suchowersky, O., Chua, P., Komiti, A., Rosas, D., Rosser, Anne Elizabeth, Price, K., Hunt, S., Jankovic, J., Ondo, W., Martin, W., King, P., Wieler, M., Sran, S., de Yébenes, J. G., Dubinsky, R., PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Publikováno v: Frontiers in Aging Neuroscience, Vol 6 (2014)
Frontiers in Aging Neuroscience

There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e325c116dde96ce1dff0e15c74ce5aa
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00078/full

Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study

Autor: Paulsen, JS, Long, JD, Johnson, HJ, Aylward, EH, Ross, CA, Williams, JK, Nance, MA, Erwin, CJ, Westervelt, HJ, Harrington, DL, Bockholt, HJ, Zhang, Y, McCusker, EA, Chiu, EM, Panegyres, PK, Cross, S, Ryan, P, Epping, EA, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Mallone, WM, Suter, G, Varvaris, M, Yoritomo, N, Griffith, J, Loy, C, Gunn, D, Guttman, M, Sheinberg, A, Law, A, Quaid, K, Wesson, M, Wojcieszek, J, Perlmutter, J, Barton, S, Smith, S, Barker, RA, Mason, S, Guzman, NV, Perlman, S, Clemente, B, Jones, R, Wood-Siverio, C, Factor, SA, Samii, A, Macaraeg, A, Lee, J, Tedesco, M, Maxwell, B, Kumar, R, Erickson, D, Nickels, B, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Geschwind, MD, Sha, S, Satris, G, Ahmed, A, Reece, C, Bura, A, Mourany, L, Pillai, J, Mazzoni, P, Marder, K, Wasserman, P, Craufurd, D, Bek, J, Howard, E, Warner, T, Burrows, M, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Wheelock, V, Kjer, L, Martin, A, Farias, S, Miedzybrodzka, Z, Rae, D

Publikováno v: Paulsen, JS; Long, JD; Johnson, HJ; Aylward, EH; Ross, CA; Williams, JK; et al.(2014). Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study. Frontiers in Aging Neuroscience, 6(APR). doi: 10.3389/fnagi.2014.00078. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2ms8c2jv

There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7c22eace304dad4db3ecfcceb9b14282
http://www.escholarship.org/uc/item/2ms8c2jv

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