Enzymatic activation in vitamin D signaling : Past, present and future

Autor: Maria Norlin, Kjell Wikvall

Vitamin D signaling is important in regulating calcium homeostasis essential for bone health but also displays other functions in cells of several tissues. Disturbed vitamin D signaling is linked to a large number of diseases. The multiple cytochrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b925fe7785124a0df6f625eeac7bf10f
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506600

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Autor: Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall

Publikováno v: Journal of Lipid Research, Vol 41, Iss 10, Pp 1629-1639 (2000)

(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of

Externí odkaz: https://doaj.org/article/99a266e80d574e8d87fe38e99085e641

Drug-Mediated Gene Regulation of Vitamin D3Metabolism in Primary Human Dermal Fibroblasts

Autor: Jan Gustafsson, Maritta Hellström Pigg, Kjell Wikvall, Maria Norlin, Johan Lundqvist, Maria Ellfolk

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 120:59-63

Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ebccaaa02737c8c87f4db1cb536f2ed
https://doi.org/10.1111/bcpt.12641

Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain

Autor: Mokhtar Almokhtar, Maria Norlin, Jonas Bergquist, Kjell Wikvall, S. J. Kumari A. Ubhayasekera

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 158:178-188

Vitamin D3 is a pro-hormone, which is sequentially activated by 25- and 1α-hydroxylation to form 25-hydroxyvitamin D3 [25(OH)D3] and 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], respectively. Subsequent inactivation is performed by 24-hydroxylation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85331c92ecd41957cb852d6e8d58585b
https://doi.org/10.1016/j.jsbmb.2015.12.010

Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system:Potential effects of vitamin D on brain steroidogenesis

Autor: Maria Norlin, Kjell Wikvall, Anne-Lie Svensson, Åsa Fex Svenningsen, Ida Emanuelsson, Mokhtar Almokhtar, Erik Nylander, Alfhild Grönbladh

Publikováno v: Emanuelsson, I, Almokhtar, M, Wikvall, K, Grönbladh, A, Nylander, E, Svensson, AL, Fex Svenningsen, Å & Norlin, M 2018, ' Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system : Potential effects of vitamin D on brain steroidogenesis. ', Neurochemistry International, vol. 113, pp. 46-55 . https://doi.org/10.1016/j.neuint.2017.11.007

Steroids are reported to have diverse functions in the nervous system. Enzymatic production of steroid hormones has been reported in different cell types, including astrocytes and neurons. However, the information on some of the steroidogenic enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6df47e857d62e6bfd479b9f1cd2332
https://findresearcher.sdu.dk:8443/ws/files/134568980/Expression_and_regulation_of_CYP17A1_and_3_hydroxysteroid_dehydrogenase_in_cells_of_the_nervous_system.pdf