Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease.

Autor: Madsen LS; Department of Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Ismail R; Department of Nuclear Medicine, Sygehus Lillebaelt, Vejle, Denmark., Parbo P; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Kjeldsen PL; Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark.; Department of Neurology, Aalborg University Hospital, Aalborg, Denmark., Schaldemose JL; Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Hansen KV; Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Gottrup H; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Aanerud J; Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark., Eskildsen SF; Department of Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Brooks DJ; Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark.; Institute of Translational and Clinical Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov; Vol. 20 (11), pp. 8028-8037. Date of Electronic Publication: 2024 Oct 11.

Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies.

Autor: Okkels N; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Horsager J; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Fedorova TD; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Knudsen K; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark., Skjærbæk C; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Andersen KB; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Labrador-Espinosa M; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain., Vestergaard K; Department of Neurology, Aalborg University Hospital, 9000 Aalborg, Denmark., Mortensen JK; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Klit H; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Møller M; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Danielsen EH; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Johnsen EL; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Bekan G; Department of Neurology, Regionshospitalet Gødstrup, 7400 Herning, Denmark., Hansen KV; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark., Munk OL; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark., Damholdt MF; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Kjeldsen PL; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Neurology, Aalborg University Hospital, 9000 Aalborg, Denmark., Hansen AK; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Nuclear Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark., Gottrup H; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Grothe MJ; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain., Borghammer P; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Jan 04; Vol. 147 (1), pp. 255-266.

Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies.

Autor: Okkels N; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Horsager J; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Labrador-Espinosa M; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain., Kjeldsen PL; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.; Department of Neurology, Aalborg University Hospital, 9000 Aalborg, Denmark., Damholdt MF; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Mortensen J; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Vestergård K; Department of Neurology, Aalborg University Hospital, 9000 Aalborg, Denmark., Knudsen K; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Andersen KB; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Fedorova TD; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Skjærbæk C; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark., Gottrup H; Department of Neurology, Aarhus University Hospital, 8200 Aarhus N, Denmark., Hansen AK; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Nuclear Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark., Grothe MJ; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain., Borghammer P; Department of Nuclear Medicine and PET, Aarhus University Hospital, 8200 Aarhus N, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Sep 01; Vol. 146 (9), pp. 3690-3704.

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study.

Autor: Ismail R; Department of Clinical Medicine, PET-Centre, Aarhus University, Aarhus, Denmark. rola.ismail@clin.au.dk., Parbo P; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, DK-8200, Aarhus N, Denmark., Madsen LS; Department of Clinical Medicine, PET-Centre, Aarhus University, Aarhus, Denmark., Hansen AK; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, DK-8200, Aarhus N, Denmark., Hansen KV; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, DK-8200, Aarhus N, Denmark., Schaldemose JL; Department of Clinical Medicine, PET-Centre, Aarhus University, Aarhus, Denmark., Kjeldsen PL; Department of Clinical Medicine, PET-Centre, Aarhus University, Aarhus, Denmark., Stokholm MG; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, DK-8200, Aarhus N, Denmark., Gottrup H; Dept. of Neurology, Aarhus University Hospital, Aarhus, Denmark., Eskildsen SF; Centre of Functionally Integrative Neuroscience (CFIN), Aarhus University, Aarhus, Denmark., Brooks DJ; Department of Clinical Medicine, PET-Centre, Aarhus University, Aarhus, Denmark.; Institute of Neuroscience, University of Newcastle upon Tyne, Tyne, UK.; Department of Medicine, Imperial College London, London, UK.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2020 May 06; Vol. 17 (1), pp. 151. Date of Electronic Publication: 2020 May 06.

Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB-PET Threshold.

Autor: Ismail R; Department of Clinical Medicine, PET-Centre, Aarhus University, Denmark., Parbo P; Department of Nuclear Medicine and PET Centre Aarhus University Hospital, Denmark., Hansen KV; Department of Clinical Medicine, PET-Centre, Aarhus University, Denmark., Schaldemose JL; Department of Clinical Medicine, PET-Centre, Aarhus University, Denmark., Dalby RB; Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Denmark., Tietze A; Institute of Neuroradiology, Charite-Universitätsmedizin Berlin, Germany., Kjeldsen PL; Department of Clinical Medicine, PET-Centre, Aarhus University, Denmark., la Cour SH; Department of Biomedicine, Centre for Integrative Sequencing iSEQ, Aarhus University, Denmark., Qvist P; Department of Biomedicine, Centre for Integrative Sequencing iSEQ, Aarhus University, Denmark., Gottrup H; Department of Neurology, Aarhus University Hospital, Denmark., Eskildsen SF; Center of Functionally Integrative Neuroscience (CFIN), Aarhus University, Denmark., Brooks DJ; Department of Clinical Medicine, PET-Centre, Aarhus University, Denmark.; Institute of Neuroscience, University of Newcastle upon Tyne, UK.; Department of Medicine, Imperial College London, UK.

Publikováno v: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2019 Jul; Vol. 29 (4), pp. 499-505. Date of Electronic Publication: 2019 May 10.