Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.

Autor: Pombo Antunes AR; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Scheyltjens I; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Lodi F; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium., Messiaen J; Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Antoranz A; Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Duerinck J; Department of Neurosurgery, UZ Brussels, Brussels, Belgium., Kancheva D; Janssen Pharmaceuticals, Beerse, Belgium., Martens L; Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Laboratory of Myeloid Cell Heterogeneity and Function, VIB Center for Inflammation Research, Ghent, Belgium., De Vlaminck K; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Van Hove H; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Kjølner Hansen SS; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Bosisio FM; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Van der Borght K; Janssen Pharmaceuticals, Beerse, Belgium., De Vleeschouwer S; Department of Neurosurgery, UZ Leuven, Leuven, Belgium.; Laboratory for Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences and Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium., Sciot R; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Bouwens L; Cell Differentiation Lab, Vrije Universiteit Brussel, Brussels, Belgium., Verfaillie M; Department of Neurosurgery, Europe Hospitals Saint Elisabeth, Ukkel, Belgium., Vandamme N; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Vandenbroucke RE; VIB Center for Inflammation Research, Gent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., De Wever O; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.; Laboratory for Experimental Cancer Research, Ghent University, Ghent, Belgium., Saeys Y; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Guilliams M; Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Gysemans C; Clinical and Experimental Endocrinology (CEE), KU Leuven, Leuven, Belgium., Neyns B; Department of Medical Oncology, UZ Brussels, Brussels, Belgium., De Smet F; Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Lambrechts D; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium., Van Ginderachter JA; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Movahedi K; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium. kiavash.movahedi@vub.be.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. kiavash.movahedi@vub.be.

Publikováno v: Nature neuroscience [Nat Neurosci] 2021 Apr; Vol. 24 (4), pp. 595-610. Date of Electronic Publication: 2021 Mar 29.