Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kizito Njah"'
Autor:
Sayan Chakraborty, Divyaleka Sampath, Melissa Ong Yu Lin, Matthew Bilton, Cheng-Kuang Huang, Mui Hoon Nai, Kizito Njah, Pierre-Alexis Goy, Cheng-Chun Wang, Ernesto Guccione, Chwee-Teck Lim, Wanjin Hong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing e
Externí odkaz:
https://doaj.org/article/66e7f31bc2564edc8b704e9a42602d0d
Autor:
Sayan Chakraborty, Kizito Njah, Ajaybabu V. Pobbati, Ying Bena Lim, Anandhkumar Raju, Manikandan Lakshmanan, Vinay Tergaonkar, Chwee Teck Lim, Wanjin Hong
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2464-2479 (2017)
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals
Externí odkaz:
https://doaj.org/article/7b021c8bd89649e6a60d9fe4ba9eca46
Publikováno v:
Trends in Cancer. 6:81-85
Angiogenesis represents a hallmark of cancer. Several proteoglycans associate with cell surface receptors and regulate angiogenesis within the tumor microenvironment (TME). We highlight the recent discovery that the proteoglycan Agrin cross talks bet
Autor:
Chwee Teck Lim, Manikandan Lakshmanan, Ajaybabu V. Pobbati, Ying Bena Lim, Sayan Chakraborty, Kizito Njah, Wanjin Hong, Vinay Tergaonkar, Anandhkumar Raju
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2464-2479 (2017)
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals
Autor:
Surender Arumugam, Manikandan Lakshmanan, Guillaume Thibault, Kizito Njah, Anandhkumar Raju, Wanjin Hong, Xiaomeng Wang, Ajaybabu V. Pobbati, Vinay Tergaonkar, Sayan Chakraborty, Beiying Qiu
Publikováno v:
Cell Reports. 28:949-965.e7
Endothelial cell (EC) recruitment is central to the vascularization of tumors. Although several proteoglycans have been implicated in cancer and angiogenesis, their roles in EC recruitment and vascularization during tumorigenesis remain poorly unders