Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kiyoyuki Omoto"'
Autor:
Rachel J. Roth Flach, Eliza Bollinger, Allan R. Reyes, Brigitte Laforest, Bethany L. Kormos, Shenping Liu, Matthew R. Reese, Luis A. Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V. Sahasrabudhe, John Knafels, Samit K. Bhattacharya, Kiyoyuki Omoto, John C. Stansfield, Liam D. Hurley, LouJin Song, Lina Luo, Susanne B. Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J. Geoly, Jake Delmore, C. Parker Siddall, Liang Xue, Ka N. Yip, Amit S. Kalgutkar, Russell A. Miller, Bei B. Zhang, Kevin J. Filipski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH k
Externí odkaz:
https://doaj.org/article/f9d9823491ce46a3808353f3a122b4ab
Autor:
Michelle R. Garnsey, Aaron C. Smith, Jana Polivkova, Autumn L. Arons, Guoyun Bai, Caroline Blakemore, Markus Boehm, Leanne M. Buzon, Sarah N. Campion, Matthew Cerny, Shiao-Chi Chang, Karen Coffman, Kathleen A. Farley, Kari R. Fonseca, Kristen K. Ford, Jeonifer Garren, Jimmy X. Kong, Martin R. M. Koos, Daniel W. Kung, Yajing Lian, Monica M. Li, Qifang Li, Luis A. Martinez-Alsina, Rebecca O’Connor, Kevin Ogilvie, Kiyoyuki Omoto, Brian Raymer, Matthew R. Reese, Tim Ryder, Lacey Samp, Kimberly A. Stevens, Daniel W. Widlicka, Qingyi Yang, Kaicheng Zhu, Jean-Philippe Fortin, Matthew F. Sammons
Publikováno v:
Journal of Medicinal Chemistry. 66:3195-3211
Autor:
Shenping Liu, Bethany L. Kormos, John D. Knafels, Parag V. Sahasrabudhe, Amy Rosado, Ruth F. Sommese, Allan R. Reyes, Jessica Ward, Rachel J. Roth Flach, Xiaochun Wang, Leanne M. Buzon, Matthew R. Reese, Samit K. Bhattacharya, Kiyoyuki Omoto, Kevin J. Filipski
Publikováno v:
Journal of Biological Chemistry. 299:102959
Autor:
David M. Bolduc, Nicholas A. Larsen, Stephanos Ioannidis, Federico Colombo, Toung-Vi Nguyen, Frédéric H. Vaillancourt, Alan Rolfe, Lihua Yu, Ping Zhu, Andrew Cook, Milena Virrankoski, Reynolds Dominic, Kiyoyuki Omoto, Shihua Yao
Publikováno v:
ACS Med Chem Lett
[Image: see text] Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis. In other cancer types, CPS1 overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65eb58d3e5de871c2ef8af973dc3067
https://europepmc.org/articles/PMC7294722/
https://europepmc.org/articles/PMC7294722/
Autor:
Christopher William West, Nigel Alan Swain, Peter J. Cox, Joseph S. Warmus, Kiyoyuki Omoto, David C. Pryde, George Salvatore Amato, Steven Michael Reister, Jamie Turner, Brett M Antonio, Aaron C. Gerlach, Brian E. Marron, Karen Padilla, Katrina Yoger, John H. Mahoney
Publikováno v:
ACS Medicinal Chemistry Letters. 8:666-671
A series of TRPA1 antagonists is described which has as its core structure an indazole moiety. The physical properties and in vitro DMPK profiles are discussed. Good in vivo exposure was obtained with several analogs, allowing efficacy to be assessed
Autor:
Robert M, Owen, David, Blakemore, Lishuang, Cao, Neil, Flanagan, Rebecca, Fish, Karl R, Gibson, Rachel, Gurrell, Chan Woo, Huh, Juha, Kammonen, Elisabeth, Mortimer-Cassen, Sarah A, Nickolls, Kiyoyuki, Omoto, Dafydd, Owen, Andy, Pike, David C, Pryde, David S, Reynolds, Rosemarie, Roeloffs, Colin, Rose, Clara, Stead, Mifune, Takeuchi, Joseph S, Warmus, Christine, Watson
Publikováno v:
Journal of medicinal chemistry. 62(12)
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABA
Autor:
Colin R. Rose, Elisabeth Mortimer-Cassen, Juha Kammonen, Rebecca L. Fish, David C. Pryde, Lishuang Cao, Sarah A. Nickolls, Neil J. Flanagan, Karl Richard Gibson, Joseph S. Warmus, Christine Anne Louise Watson, Chan Woo Huh, David J. Reynolds, Rachel Gurrell, Kiyoyuki Omoto, Andrew Pike, Clara Stead, David C. Blakemore, Rosemarie Roeloffs, Dafydd R. Owen, Mifune Takeuchi, Robert M. Owen
Publikováno v:
Journal of Medicinal Chemistry.
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABAA ligand-gated ion channel are described. From a set of initial hits multiple subseries were des
Autor:
Lishuang Cao, Aymeric Monteillier, David C. Pryde, Edward B. Stevens, Pierre-Philippe Saintot, Alexandre J.C. Loucif, Sergio Lainez, Kiyoyuki Omoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4919-4924
TRESK (Twik RElated Spinal cord K+ channel) is a member of the Twin Pore Domain potassium channel (K2P) family responsible for regulating neuronal excitability in dorsal root ganglion (DRG) and trigeminal (TG) neurons, peripheral neurons involved in
Autor:
Alan Daniel Brown, Joseph S. Warmus, Matthew Corbett, Yoshihisa Murata, C. Elizabeth Payne, Kiyoyuki Omoto, Tanya L. Hay, Miller Duncan Charles, Sharan K. Bagal, Peter J. Bungay, David C. Blakemore, Edward B. Stevens, Kemp Mark Ian
Publikováno v:
MedChemComm. 7:1925-1931
Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we describe the discovery and optimisation of a Nav1.8 inhibiting phenyl imidazole series that delivers chemical equi
Autor:
Xingfeng Bao, Patricia Bouchard, Kiyoyuki Omoto, Alan Rolfe, Tuong-Vi Nguyen, Ping Zhu, Lihua Yu, Shouyong Peng, Jiyuan Ke, Kuan-Chun Huang, Sean Yu, Frédéric H. Vaillancourt, Anant A. Agrawal, Stephanos Ioannidis, Nicholas A. Larsen, David M. Bolduc, Shihua Yao, Anand Selvaraj, Jiayi Wu, Federico Colombo
Publikováno v:
Cell Chemical Biology. 27:259-268.e5
Carbamoyl phosphate synthetase 1 (CPS1) catalyzes the first step in the ammonia-detoxifying urea cycle, converting ammonia to carbamoyl phosphate under physiologic conditions. In cancer, CPS1 overexpression supports pyrimidine synthesis to promote tu