Výsledky vyhledávání - "Kiyouhisa Ohnishi"

Akademický článek

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

Autor: Tomohiro Umeda, Tetsuya Kimura, Kayo Yoshida, Keizo Takao, Yuki Fujita, Shogo Matsuyama, Ayumi Sakai, Minato Yamashita, Yuki Yamashita, Kiyouhisa Ohnishi, Mamiko Suzuki, Hiroshi Takuma, Tsuyoshi Miyakawa, Akihiko Takashima, Takashi Morita, Hiroshi Mori, Takami Tomiyama

Publikováno v: Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-15 (2017)

Abstract The E693Δ (Osaka) mutation in APP is linked to familial Alzheimer’s disease. While this mutation accelerates amyloid β (Aβ) oligomerization, only patient homozygotes suffer from dementia, implying that this mutation is recessive and cau

Externí odkaz: https://doaj.org/article/22482dc3cde0468b9c8450aa2fae8a6a

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Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

Autor: Akihiko Takashima, Takashi Morita, Hiroshi Takuma, Kiyouhisa Ohnishi, Tomohiro Umeda, Keizo Takao, Yuki Yamashita, Kayo Yoshida, Takami Tomiyama, Mamiko Suzuki, Shogo Matsuyama, Ayumi Sakai, Tsuyoshi Miyakawa, Hiroshi Mori, Yuki Fujita, Minato Yamashita, Tetsuya Kimura

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-15 (2017)

The E693Δ (Osaka) mutation in APP is linked to familial Alzheimer’s disease. While this mutation accelerates amyloid β (Aβ) oligomerization, only patient homozygotes suffer from dementia, implying that this mutation is recessive and causes loss-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830cbec50ca1bd3709409292f1975e9e
http://europepmc.org/articles/PMC5537936

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Regulation of TCR V 2 gene rearrangement by the helix-loop-helix protein, E2A

Autor: Nobuyuki Tamaki, Shuji Sakamoto, Masatoshi Nozaki, Kiyouhisa Ohnishi, Toshifumi Uejima, Yasutoshi Agata, Itaru Yanagihara, Kousho Wakae, Nagahiro Minato

Publikováno v: International Immunology. 23:297-305

V(D)J recombination of Ig and TCR genes is strictly regulated by the accessibility of target gene chromatin in a lineage- and stage-specific manner. In the mouse TCRγ locus, rearrangement of the Vγ2 gene predominates over Vγ3 rearrangement in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb72f44b4609ad1d46a38978ff01ff8e
https://doi.org/10.1093/intimm/dxr005

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Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus

Autor: Kentaro Shiraki, Kumiko Nakahira, Takeshi Honda, Kouta Mayanagi, Hiroshi Hashimoto, Itaru Yanagihara, Kiyouhisa Ohnishi, Satoru Unzai

Publikováno v: FEMS Microbiology Letters. 318:10-17

The formation of nonspecific ion channels by small oligomeric amyloid intermediates is toxic to the host's cellular membranes. Thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) are major virulence factors of Vibrio parahaemolyticus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::712d2fc202cdf223371b5b250f8fa8c0
https://doi.org/10.1111/j.1574-6968.2011.02233.x

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Structure and Functional Characterization of Vibrio parahaemolyticus Thermostable Direct Hemolysin

Autor: Takahisa Ikegami, Hiroshi Hashimoto, Takashi Fukui, Mitsunori Ikeguchi, Kiyouhisa Ohnishi, Shuji Kaieda, Takeshi Honda, Mamoru Sato, Tsutomu Yamane, Toshiyuki Shimizu, Itaru Yanagihara, Kumiko Nakahira, Shin'ichiro Kajiyama, Daizo Hamada, Kouta Mayanagi

Publikováno v: Journal of Biological Chemistry. 285:16267-16274

Thermostable direct hemolysin (TDH) is a major virulence factor of Vibrio parahaemolyticus that causes pandemic foodborne enterocolitis mediated by seafood. TDH exists as a tetramer in solution, and it possesses extreme hemolytic activity. Here, we p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f38b2c2b44ae4bc0fd9bb30a05b30b
https://doi.org/10.1074/jbc.m109.074526

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Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice

Autor: Tomoko Ozeki, Tetsuya Kimura, Hiroshi Takuma, Tomohiro Umeda, Kiyouhisa Ohnishi, Hiroshi Mori, Takenari Yamashita, Takami Tomiyama, Akihiko Takashima

Publikováno v: The American journal of pathology. 183(1)

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a neurodegenerative disorder caused by mutations in the tau gene. Many mutations identified in FTDP-17 have been shown to affect tau exon 10 splicing in vitro , which presu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ae019568889392465e5300baa2c8ff
https://pubmed.ncbi.nlm.nih.gov/23680655

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Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus

Autor: Kiyouhisa, Ohnishi, Kumiko, Nakahira, Satoru, Unzai, Kouta, Mayanagi, Hiroshi, Hashimoto, Kentaro, Shiraki, Takeshi, Honda, Itaru, Yanagihara

Publikováno v: FEMS microbiology letters. 318(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04ac40b52897fd3c87a22f2faf20ae92
https://pubmed.ncbi.nlm.nih.gov/21291495

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RodZ regulates the post-transcriptional processing of the Shigella sonnei type III secretion system

Autor: Shouji Yamamoto, Itaru Yanagihara, Makoto Ohnishi, Haruo Watanabe, Akira Ishihama, Jiro Mitobe, Kiyouhisa Ohnishi

Publikováno v: EMBO reports. 12(9)

The expression of the type III secretion system—a main determinant of virulence in Shigella—is controlled by regulator cascades VirF-InvE (VirB) and CpxAR two-component system. A screen for mutants that restore virulence in the cpxA background le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2206dfc727c3e8387970db769c434d
https://pubmed.ncbi.nlm.nih.gov/21779005

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo

Autor: Hiroyuki Iso, Kiyouhisa Ohnishi, Hiroshi Takuma, Hiroshi Mori, Takami Tomiyama, Hiroyuki Shimada, Rie Teraoka, Mary P. Lambert, Kazuchika Nishitsuji, Shogo Matsuyama, Takenari Yamashita, Kenichi Ishibashi, Naomi Sakama, Tomohiro Umeda, Kazuhiro Ito, William L. Klein

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(14)

Although amyloid beta (Abeta) oligomers are presumed to cause synaptic and cognitive dysfunction in Alzheimer's disease (AD), their contribution to other pathological features of AD remains unclear. To address the latter, we generated APP transgenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692c8329c1f830ec06125f76c7dd6a2c
https://pubmed.ncbi.nlm.nih.gov/20371804

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