Výsledky vyhledávání - "Kiyotoshi Mori"

Akademický článek

K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model

Autor: Yoshiyuki Sugimoto, Yozo Kojima, Atsushi Inayoshi, Kazuaki Inoue, Hiroko Miura-Kusaka, Kiyotoshi Mori, Osamu Saku, Hiroshi Ishida, Eri Atsumi, Yoshisuke Nakasato, Shiro Shirakura, Shin-ichiro Toki, Katsumi Shinoda, Nobuyuki Suzuki

Publikováno v: Journal of Pharmacological Sciences, Vol 123, Iss 3, Pp 256-266 (2013)

Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. During inflammation, TRPV1 is reported to be sens

Externí odkaz: https://doaj.org/article/d34e73b9e5ae401c9b528731d20585d5

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A novel mouse model of cutaneous T-cell lymphoma revealed the combined effect of mogamulizumab with psoralen and ultraviolet a therapy

Autor: Keiko Nakahashi, Kaito Nihira, Miyoko Suzuki, Toshihiko Ishii, Kazuhiro Masuda, Kiyotoshi Mori

Publikováno v: Experimental dermatology. 31(11)

Mycosis fungoides (MF) is a subtype of cutaneous T-cell lymphoma (CTCL). Topical or systemic treatment with psoralen, such as 8-methoxypsoralen (8-MOP), followed by ultraviolet A (UVA) irradiation (PUVA therapy) is an effective phototherapy for early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea8c23473c1c6edbaf4df992203a208
https://pubmed.ncbi.nlm.nih.gov/35801380

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The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma

Autor: Ayumi, Kaneda, Toshihiro, Seike, Tomohiro, Danjo, Takahiro, Nakajima, Nobumasa, Otsubo, Daisuke, Yamaguchi, Yoshiro, Tsuji, Kaori, Hamaguchi, Mai, Yasunaga, Yoichi, Nishiya, Michihiko, Suzuki, Jun-Ichi, Saito, Rie, Yatsunami, Satoshi, Nakamura, Yoshitaka, Sekido, Kiyotoshi, Mori

Publikováno v: Am J Cancer Res

The Hippo signaling pathway regulates cell fate and organ development. In the Hippo pathway, transcriptional enhanced associate domain (TEAD) which is a transcription factor is activated by forming a complex with yes-associated protein 1 (YAP1) or tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b9cd2e0dae781e69fc45755972dc3ea
https://pubmed.ncbi.nlm.nih.gov/33415007

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Abstract 2913: Entinostat (KHK2375), class I histone deacetylase inhibitor, regulates human Treg function by decreasing Foxp3 expression and effector Treg population

Autor: Yozo Nishimura, Kenji Tamura, Kiyotoshi Mori, Norikazu Masuda, Hiromichi Kosaka, Shigehira Saji, Ayumi Kaneda, Hiroji Iwata

Publikováno v: Cancer Research. 80:2913-2913

Objective: Entinostat (KHK2375 also known as MS-275, SNDX-275 and ZN244894), a synthetic benzamide derivative, is a class I selective histone deacetylase inhibitor. Entinostat increases the acetylation of histone and non-histone proteins. Change of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::010d04dde0ea2237d85115b2bee032f4
https://doi.org/10.1158/1538-7445.am2020-2913

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The Noncompetitive Antagonism of Histamine H1 Receptors Expressed in Chinese Hamster Ovary Cells by Olopatadine Hydrochloride: Its Potency and Molecular Mechanism

Autor: Kozue Hayashi, Kiyotoshi Mori, Yuichi Matsumoto, Jun Funahashi, Hiroshi Yano

Publikováno v: Pharmacology. 81:266-274

Calcium responses to various concentrations of histamine were monitored in Chinese hamster ovary cells stably expressing the human histamine H1 receptor. The effects of various histamine H1 receptor antagonists on the dose-response curve for histamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36aa9f75f0a6ce3d960db9b6e421fab4
https://doi.org/10.1159/000115970

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The noncompetitive antagonism of histamine H1 receptors expressed in Chinese hamster ovary cells by olopatadine hydrochloride: its potency and molecular mechanism

Autor: Yuichi, Matsumoto, Jun, Funahashi, Kiyotoshi, Mori, Kozue, Hayashi, Hiroshi, Yano

Publikováno v: Pharmacology. 81(3)

Calcium responses to various concentrations of histamine were monitored in Chinese hamster ovary cells stably expressing the human histamine H(1) receptor. The effects of various histamine H(1) receptor antagonists on the dose-response curve for hist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbf49acad9ed73c4a29a72756c255259
https://pubmed.ncbi.nlm.nih.gov/18268402

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Biochemical evidence for the interaction of regulatory subunit of cAMP-dependent protein kinase with IDA (Inter-DFG-APE) region of catalytic subunit

Autor: Kiyotoshi Mori, Mamoru Aoto, Ayako Sato, Yasuo Fukami, Setsuko Sahara, Ken-ichi Sato, Alexander A. Tokmakov, Hiroshi Kaise

Publikováno v: FEBS letters. 384(2)

To explore the structural basis required for the holoenzyme formation of cAMP-dependent protein kinase, we have prepared rabbit anti-peptide antibodies that can block the holoenzyme formation without affecting the catalytic activity of the enzyme. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd01fcdefa38a00464b4cb0894d663d
https://pubmed.ncbi.nlm.nih.gov/8612810

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