Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kiyotaka Yamamoto"'
Publikováno v:
IEEJ Transactions on Electronics, Information and Systems. 136:1661-1667
Publikováno v:
Molecular and Cellular Biochemistry. 293:63-69
The changes in gene expression during senescence are very interesting. Early population doubling cDNA-1 (EPC-1, also known as pigment epithelial derived factor, PEDF) is one of the genes whose expression decreases dramatically during cellular aging.
Autor:
Kiyotaka Yamamoto, Tomomi Tadokoro, Kiyoshi Furukawa, Akiyoshi Taniguchi, Masahiko Ikekita, Iku Kuwahara, Hirosuke Fujisawa, Takeshi Sato
Publikováno v:
Glycoconjugate Journal. 23:443-452
Human diploid fibroblastic cell line, TIG-3, has a finite life span of about 80 population doubling levels (PDL), and is used for in vitro aging studies. Young cells (PDL 23) grew to higher cell densities at a higher growth rate than aged cells (PDL
Autor:
Kiyotaka Yamamoto, Kikuo Ohno, Shogo Imae, Kazuhiko Nakagawa, Takekane Yamaguchi, Mitsuru Seida, Yoji Tanaka, Shimpei Yamada
Publikováno v:
Cerebrovascular Diseases. 19:157-164
Background: Acute blood pressure (BP) elevation and cardiac abnormalities are known to follow ischemic stroke. Brain natriuretic peptide (BNP), which is produced in response to such cardiovascular alterations, is expected to play a hemodynamic role.
Autor:
Junping Zhang, Mari Yamamoto, Naofumi Yamamoto, Boli Zhang, Masaru Aoyagi, Kiyotaka Yamamoto, Misaki Kanai
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1010-1013
Qing Nao Yi Zhi Fang (QNYZ), a Chinese medicine, has been developed as a drug for the prevention and treatment of vascular dementia. We examined the effects of QNYZ-treated serum and QNYZ on the proliferation of human arterial smooth muscle cells (SM
Autor:
Tomoko Yonezawa, Yoshifumi Ninomiya, Teruhito Yoshitaka, Kiyotaka Yamamoto, Shuichi Hirano, Aiji Ohtsuka, Hiroyuki Nomoto
Publikováno v:
Glia. 44:190-204
We report the molecular cloning of a new member of the transmembrane-type immunoglobulin superfamily and designate the encoded protein as limitrin, since it localized selectively to glia limitans in mouse brain. Limitrin cDNA was obtained using a sub
Autor:
Kouichi Itoh, Toshitaka Oohashi, Tomoko Yonezawa, Fumio Shiraga, Kiyotaka Yamamoto, Katsuhiko Ono, Hiroshi Ohtsuki, Yoshifumi Ninomiya, Hiroyuki Nomoto
Publikováno v:
Journal of Biochemistry. 134:231-238
A novel oligodendrocyte (OL)-specific cDNA was isolated from brain capillary endothelial cells and characterized. The cDNA encodes a protein of 1099 amino acids that contains a signal peptide and a transmembrane domain. The protein was expressed in m
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 504:57-65
Using a human lymphoblastoid cell line WTK-1, we applied multicolor fluorescence in situ hybridization (mFISH) technique to analyze mitomycin C (MMC)-induced chromatid exchanges, focusing especially on the triradial chromosomes. It was found that the
Publikováno v:
Cell Biology International. 26:441-449
Prolapsus uteri in pelvic supportive disorders are common in elderly women, and their etiology remains unclear. We examined elastin-binding proteins (EBPs) and binding sites in cultured cardinal ligament fibroblasts derived from elderly patients with
Autor:
Kimiyoshi Hirakawa, Kikuo Ohno, Kazuhiko Nakagawa, Goro Nagashima, Lian Duan, Masaru Aoyagi, Kiyotaka Yamamoto, Yasuhiko Nagasaka, Masashi Tamaki
Publikováno v:
Journal of Neuro-Oncology. 52:23-36
Most tumors, including gliomas, are resistant to tumor necrosis factor (TNF) cytotoxicity unless protein or RNA synthesis is inhibited. We investigated the effects of the combined use of TNF-alpha and cisplatin (CDDP) on cultured malignant glioma cel