Výsledky vyhledávání - "Kiyotaka Koyabu"

CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability

Autor: Hiroko Endo, Junko Shinozaki, Kaori Miyamoto, Chiho Nagasawa, Hitoshi Watanabe, Shinobu Suzuki, Shota Saiki, Chiaki Nakamori, Kiyotaka Koyabu, Yayoi Honda, Chiaki Nakayama, Ikumi Washio, Takeshi Kunimatsu, Hisashi Nogawa, Hiroshi Iwasaki, Etsushi Takahashi, Yumiko Nozaki, Atsuhiro Yamanishi, Tetsuji Itoh

Publikováno v: Regulatory Toxicology and Pharmacology. 77:75-86

In vitro screening of hERG channels are recommended under ICH S7B guidelines to predict drug-induced QT prolongation and Torsade de Pointes (TdP), whereas proarrhythmia is known to be evoked by blockage of other ion channels involved in cardiac contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c3022873eb82f6c37aaf1b87424a3a
https://doi.org/10.1016/j.yrtph.2016.02.007

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Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Publikováno v: Journal of medicinal chemistry. 61(12)

Accumulation of Aβ peptides is a hallmark of Alzheimer’s disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key enzyme responsible for producing Aβ peptides, and thus agents that inhibit BACE1 shou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601e930231423ee6e8972d7b96fcf279
https://pubmed.ncbi.nlm.nih.gov/29733614

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Distinct Relations Among Plasma Concentrations Required for Different Pharmacological Effects in Oxycodone, Morphine, and Fentanyl

Autor: Ikuko Nishino, Naoko Habu-Tomita, Yuji Inoue, Kenkichi Nanba, Hiroshi Hashimoto, Hisanori Ito, Atsushi Nakamura, Akira Kato, Katsumi Koike, Kayo Hamaguchi, Eriko Noshi, Kiyotaka Koyabu, Kazuhisa Minami, Tsuyoshi Kihara, Yoshito Okabayashi, Minoru Narita, Yuka Iwamoto, Minoru Hasegawa, Tsutomu Suzuki

Publikováno v: Journal of Pain & Palliative Care Pharmacotherapy. 25:318-334

Several clinical reports showed that adverse effect profiles are not the same in morphine, oxycodone, and fentanyl. The authors investigated whether the relationship between plasma concentrations for antinociceptive effect and for various pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811bc840641f1f5e45a5f61920ac826a
https://doi.org/10.3109/15360288.2011.620689

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Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice

Autor: Masami Eigyo, Teruo Shiomi, Yuzuru Inoue, Isako Sakaguchi, Chiyomi Ishibashi, Shunji Murata, Kiyotaka Koyabu, Akira Matsushita, Ikuo Adachi, Motohiko Ueda

Publikováno v: Japanese journal of pharmacology. 65(2)

S-312, S-312-d, but not S-312-l, L-type calcium channel antagonists, showed anticonvulsant effects on the audiogenic tonic convulsions in DBA/2 mice; and their ED50 values were 18.4 (12.8-27.1) mg/kg, p.o. and 15.0 (10.2-23.7) mg/kg, p.o., respective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de976f90a18651cf2253fe0171c86e
https://pubmed.ncbi.nlm.nih.gov/7967231

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