Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Kiyoshi Yamaguchi"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Deregulation of the Wnt/β-catenin pathway is associated with the development of human cancer including colorectal and liver cancer. Although we previously showed that histidine ammonia lyase (HAL) was transcriptionally reduced by the β-cat
Externí odkaz:
https://doaj.org/article/cfe714ca98a74825ba13266f4890aa9e
Autor:
Xinyi Zeng, Teh-Wei Wang, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshikazu Johmura, Makoto Nakanishi
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101943- (2024)
Objectives: Adipose tissue is an endocrine and energy storage organ composed of several different cell types, including mature adipocytes, stromal cells, endothelial cells, and a variety of immune cells. Adipose tissue aging contributes to the pathog
Externí odkaz:
https://doaj.org/article/d4df8a00e52b49dc89a15ccb72df509b
Autor:
Noritaka Tanaka, Hikari Okada, Kiyoshi Yamaguchi, Masahide Seki, Daisuke Matsubara, Noriko Gotoh, Yutaka Suzuki, Yoichi Furukawa, Taro Yamashita, Jun-ichiro Inoue, Shuichi Kaneko, Takeharu Sakamoto
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-12 (2023)
Abstract Given the lack of therapeutic targets, the conventional approach for managing triple-negative breast cancer (TNBC) involves the utilization of cytotoxic chemotherapeutic agents. However, most TNBCs acquire resistance to chemotherapy, thereby
Externí odkaz:
https://doaj.org/article/bb2d8ae7e71c4a039d982e2c5ef19671
Autor:
Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113918- (2024)
Summary: Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs con
Externí odkaz:
https://doaj.org/article/c85fa5cd49224938abb19488da79baeb
Autor:
Hiroki Tage, Kiyoshi Yamaguchi, Saya Nakagawa, So Kasuga, Kiyoko Takane, Yoichi Furukawa, Tsuneo Ikenoue
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13426-13437 (2023)
Abstract Background Abnormal activation of Wnt/β‐catenin signaling is associated with various aspects of cancer development. This study explored the roles of novel target genes of the Wnt/β‐catenin signaling pathway in cancer cells. Methods Usi
Externí odkaz:
https://doaj.org/article/87f8dda8e3a84514b88a7f8bda927985
Autor:
Kota Washimi, Rika Kasajima, Eigo Shimizu, Shinya Sato, Yoichiro Okubo, Emi Yoshioka, Hiroto Narimatsu, Toru Hiruma, Kotoe Katayama, Rui Yamaguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Tomoyuki Yokose, Yohei Miyagi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Myxofibrosarcoma (MFS) and undifferentiated sarcoma (US) have been considered as tumors of the same lineage based on genetic/epigenetic profiling. Although MFS shows a notably better prognosis than US, there are no clear criteria for disting
Externí odkaz:
https://doaj.org/article/f8c48a501cdd40eab902075a4f8a951f
Autor:
Kenta Takeuchi, Shunsuke Tabe, Kenta Takahashi, Kenji Aoshima, Megumi Matsuo, Yasuharu Ueno, Yoichi Furukawa, Kiyoshi Yamaguchi, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113420- (2023)
Summary: The aggressiveness of pancreatic ductal adenocarcinoma (PDAC) is affected by the tumor microenvironment (TME). In this study, to recapitulate the PDAC TME ex vivo, we cocultured patient-derived PDAC cells with mesenchymal and vascular endoth
Externí odkaz:
https://doaj.org/article/60c92d8cab9240c1b5e205b61ce0efa4
Autor:
Seina Ohe, Yuji Kubota, Kiyoshi Yamaguchi, Yusuke Takagi, Junichiro Nashimoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoichi Furukawa, Mutsuhiro Takekawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.
Externí odkaz:
https://doaj.org/article/25151774c4324719bb372acd2dd5e18f
Autor:
Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, Daisuke Shinoda, Atsunori Saraya, Fumio Arai, Kiyoshi Yamaguchi, Yoichi Furukawa, Haruhiko Koseki, Tomokatsu Ikawa, Atsushi Iwama
Publikováno v:
eLife, Vol 12 (2023)
Polycomb repressive complex (PRC) 1 regulates stem cell fate by mediating mono-ubiquitination of histone H2A at lysine 119. While canonical PRC1 is critical for hematopoietic stem and progenitor cell (HSPC) maintenance, the role of non-canonical PRC1
Externí odkaz:
https://doaj.org/article/03684bcd0ae647a1be463ba6ff163101
Autor:
Kiyoshi Yamaguchi, Saya Nakagawa, Akari Saku, Yumiko Isobe, Rui Yamaguchi, Paul Sheridan, Kiyoko Takane, Tsuneo Ikenoue, Chi Zhu, Masashi Miura, Yuya Okawara, Satoru Nagatoishi, Hiroko Kozuka-Hata, Masaaki Oyama, Susumu Aikou, Yuka Ahiko, Dai Shida, Kouhei Tsumoto, Satoru Miyano, Seiya Imoto, Yoichi Furukawa
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106563- (2023)
Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncov
Externí odkaz:
https://doaj.org/article/40eae7249af94873810670d3565eb286