Výsledky vyhledávání - "Kiyoshi Takegawa"

Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats

Autor: Hisayoshi Takagi, Hiroshi Onodera, Kazuo Yasuhara, Kiyoshi Takegawa, Toru Tamura, Masahiro Nasu, Masao Hirose, Kunitoshi Mitsumori

Publikováno v: Cancer Letters. 178:1-9

In order to improve the sensitivity of our previously established thyroid carcinogenesis model and to clarify whether endocrine disrupting chemicals with weak estrogenic activity have any modifying effects on the development of thyroid proliferative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9ffe7816c3e65210ced4b31d8d05fe
https://doi.org/10.1016/s0304-3835(01)00804-7

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Modifying Effects of Endocrine Disrupting Chemicals on N-bis(2-hydroxypropyl) Nitrosamine and Sulfadimethoxine-Induced Thyroid Carcinogenesis in Rats

Autor: Hisayoshi Takagi, Toru Tamura, Masao Hirose, Kiyoshi Takegawa, Hiroshi Onodera, Masahiro Nasu, Kazuo Yasuhara, Kunitoshi Mitsumori

Publikováno v: Journal of Toxicologic Pathology. 14:121-128

To clarify whether 17β-estradiol 3-benzoate (EB), methoxychlor (MXC), atrazine (ATR), or bisphenol A (BPA) have any modifying effects on relatively late stages of thyroid carcinogenesis, six-week old female castrated F344 rats in Experiments 1 and 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::371f18266bceaeef40ea30691228be9c
https://doi.org/10.1293/tox.14.121

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Large amount of vitamin A has no major effects on thyroidal hormone synthesis in two-stage rat thyroid carcinogenesis model using N-bis (2-hydroxypropyl) nitrosamine and thiourea

Autor: Kiyoshi Takegawa, Shiro Takagi, Tokuma Yanai, Toshiaki Masegi, Masaki Takeuchi, Tsuneyo Yamada, Masamitsu Sakamori, Megumi Koremoto, Kunitoshi Mitsumori

Publikováno v: Europe PubMed Central

In our previous investigation, which focused on two-stage carcinogenicity in the thyroid, rats were administered N-bis(2-hydroxypropyl)nitrosamine (DHPN), followed by thiourea (TU) over an experimental period of 19 weeks. Simultaneous treatment with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b867bdd59aa328cd2b8f6080eef0dc6c
https://doi.org/10.2131/jts.25.67

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Liver Tumor Promoting Effects of Febantel in a Two-stage Hepatocarcinogenesis Model of Rats Using D-galactosamine and Diethylnitrosamine

Autor: Hiroshi Onodera, Masahiro Kikuchi, Kiyoshi Takegawa, Kazuo Yasuhara, Masao Hirose, Tsutomu Ichiki, Chikako Uneyama, Kunitoshi Mitsumori

Publikováno v: Journal of Toxicologic Pathology. 12:113-117

To examine whether febantel has a tumor promoting activity, a total of 50 male F344 rats, divided into five groups each consisting of 10 rats, were initiated with a single intraperitoneal injection of 100 mg/kg of diethylnitrosamine (DEN). Starting 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::141a6937f2fdc84c4eb0e254ca42f3e8
https://doi.org/10.1293/tox.12.113

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Promoting effects of kojic acid due to serum TSH elevation resulting from reduced serum thyroid hormone levels on development of thyroid proliferative lesions in rats initiated with N-bis(2-hydroxypropyl)nitrosamine

Autor: Toru Tamura, Kazuo Yasuhara, Kiyoshi Takegawa, Masakazu Takahashi, Michihito Takahashi, Hiroshi Onodera, Kunitoshi Mitsumori, Takushi Funakoshi

Publikováno v: Carcinogenesis. 20:173-176

In order to examine whether kojic acid (KA) exerts a promoting effect on thyroid carcinogenesis, male F344 rats were initiated with N-bis(2-hydroxypropyl)nitrosamine (BHP; 2800 mg/kg body wt, single s.c. injection) and, starting 1 week later, receive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d946ad060d6404eb91e0fa145e12bd
https://doi.org/10.1093/carcin/20.1.173

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Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after DHPN initiation

Autor: Takushi Funakoshi, Kiyoshi Takegawa, Kazuo Yasuhara, Masakazu Takahashi, Toru Tamura, Masao Hirose, Kunitoshi Mitsumori, Hiroshi Onodera, Hisayoshi Takagi

Publikováno v: The Journal of Toxicological Sciences. 24:145-155

Time course changes in thyroid proliferative lesions as well as related hormone levels in the blood of male F344 rats given N-bis(2-hydroxypropyl)nitrosamine (DHPN: 2800 mg/kg body weight, single s.c. injection) as an initiation treatment followed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df5aa86d36e63ceb5ac477b98b6822
https://doi.org/10.2131/jts.24.3_145

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Involvement of apoptosis in the rat germ cell degeneration induced by nitrobenzene

Autor: Michihito Takahashi, Chikako Uneyama, Kunitoshi Mitsumori, Hiroshi Onodera, Kazutoshi Shinoda, Takashi Umemura, Kazuo Yasuhara, Kiyoshi Takegawa

Publikováno v: Archives of Toxicology. 72:296-302

Nitrobenezene (NB) produces germ cell degeneration, especially of spermatocytes in rats. To examine the possible involvement of apoptosis in this process, the extent and nature of nuclear DNA fragmentation after NB dosing were assessed using both ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0909acfdda2030f9e137cc0e67b194
https://doi.org/10.1007/s002040050505

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Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Autor: Hiroshi Onodera, Takeo Shimo, Kiyoshi Takegawa, Keisuke Kitaura, Kunitoshi Mitsumori, Michihito Takahashi, Kazuo Yasuhara

Publikováno v: Japanese Journal of Cancer Research : Gann

In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c757ccf5aa93b391e045b3f15de611cf
https://doi.org/10.1111/j.1349-7006.1998.tb00536.x

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Immunohistochemical studies of TSH-producing cells in the pituitary and expression of growth factors in thyroidal proliferative lesions in rats treated with thiourea and excess vitamin A

Autor: Yuzo Hayashi, Hiroshi Onodera, Michihito Takahashi, Kunitoshi Mitsumori, Toshiaki Masegi, Kazuo Yasuhara, Tokuma Yanai, Kiyoshi Takegawa

Publikováno v: Europe PubMed Central

Changes of TSH-producing cells in the pituitary and thyroid expression of the growth factors, transforming growth factor alpha (TGF alpha) and epidermal growth factor receptor (EGFR), as well as cyclin D1, were investigated immunohistochemically in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aeaf7bb2e82db3282b887f565dd377
https://doi.org/10.2131/jts.23.3_213

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Effects of Simultaneous Treatment with Excess Amounts of Vitamin A and Goitrogens on Thyroid Tumorigenesis in Rats

Autor: Kazuo Yasuhara, Masakazu Takahashi, Michihito Takahashi, Hiroshi Onodera, Toshiaki Masegi, Kiyoshi Takegawa, Takeo Shimo, Mamoru Mutai, Kunitoshi Mitsumori, Tokuma Yanai

Publikováno v: Journal of Toxicologic Pathology. 10:91-96

In order to investigate the effects of vitamin A (VA) supplementation on thyroid proliferative lesions associated with goitrogens other than thiourea, F344 rats were given VA in the diet at 0.1% and drinking water containing sulfadimethox-ine, propyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f11817aaf21d2a9cf20a4ffe33af4d0d
https://doi.org/10.1293/tox.10.91

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