Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Kiyoshi Takasuna"'
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Akademický článek
Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome
Autor: Katsuyoshi Chiba, Atsushi Sugiyama, Kazuo Watanabe, Kiyoshi Takasuna, Keitaro Hashimoto
Publikováno v: Journal of Pharmacological Sciences, Vol 100, Iss 1, Pp 88-92 (2006)
Abstract.: Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral
Externí odkaz: https://doaj.org/article/5022a7149cc94e96a1d76099466f2839
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3
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor
Autor: Tomihisa Yokoyama, Sakiko Takahashi, Kiyoshi Takasuna, Noriyuki Hayashi, Hiroyuki Kobayashi, Ryuta Koishi, Chie Fujiwara, Eri Tokumaru, Yasuyuki Abe, Kyosuke Tanaka, Sayaka Suzuki, Kazufumi Kubota, Daigo Asano, Narayan Karanjule, Tsuyoshi Shinozuka, Masahiro Inoue, Hiroko Kimoto, Tsuda Toshifumi, Yutaka Kitano, Kiyono Ueda, Toshiyuki Watanabe, Yuki Domon, Tomoko Sakakura, Akiko Shimizugawa
Publikováno v: Journal of Medicinal Chemistry. 63:10204-10220
A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory pot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dfbfcf9264e87757e4b9e81ee00d139
https://doi.org/10.1021/acs.jmedchem.0c00259
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4
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment
Autor: Takayuki Oka, Kiyoshi Takasuna, András Horváth, Tom A. Goetze, Nadine Becker, Markus Rapedius, Sonja Stoelzle-Feix, Nina Brinkwirth, Yuka Hasegawa, Hatsue Furukawa, Alison Obergrussberger, Niels Fertig, Maria Giustina Rotordam
Publikováno v: Journal of pharmacological and toxicological methods. 112
Introduction For reliable identification of cardiac safety risk, compounds should be screened for activity on cardiac ion channels in addition to hERG, including NaV1.5 and CaV1.2. We identified different parameters that might affect IC50s of compoun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cdc4d4089be5599ebbd22119c01be3
https://pubmed.ncbi.nlm.nih.gov/34500078
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7
On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development
Autor: Masao Odaka, Kiyoshi Takasuna, Yasuyuki Abe, Yumiko Asahi, Atsushi Sanbuissho, Fumimasa Nomura, Kenji Matsuura, Akihiro Hattori, Kenji Yasuda, Tomoyuki Kaneko, Tomoyo Hamada
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
We examined a simultaneous combined spatiotemporal field potential duration (FPD) and cell-to-cell conduction time (CT) in lined-up shaped human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using an on-chip multielectrode array (MEA) system
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761bfb1ce693a71eb35b1de2344e2d25
http://link.springer.com/article/10.1038/s41598-018-32921-1
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9
Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi)
Autor: Kiyoshi Takasuna, Tomohiro Hayakawa, Katsuyuki Kazusa
Publikováno v: Current pharmaceutical biotechnology. 21(9)
Current cardiac safety assessment platforms (in vitro hERG-centric, APD, and/or in vivo animal QT assays) are not fully predictive of drug-induced Torsades de Pointes (TdP) and do not address other mechanism-based arrhythmia, including ventricular ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0dd22ed18ff78416f71f0c577f7276
https://pubmed.ncbi.nlm.nih.gov/31749424
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10
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment
Autor: Takayuki Oka, Alison Obergrussberger, Søren Friis, Hatsue Furukawa, Nina Brinkwirth, Sonja Stoelzle-Feix, Atsushi Ohtsuki, Yuka Hasegawa, Kiyoshi Takasuna, Niels Fertig, Masafumi Doi, Nadine Becker
Publikováno v: Journal of Pharmacological and Toxicological Methods. 105:106884
Introduction Screening compounds for activity on the hERG channel using patch clamp is a crucial part of safety testing. Automated patch clamp (APC) is becoming widely accepted as an alternative to manual patch clamp in order to increase throughput w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a232b0cdc1e86e3a7f7560e3afb49141
https://doi.org/10.1016/j.vascn.2020.106884
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