Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Kiyoshi Ohtani"'
Autor:
Keigo Araki, Takeru Torii, Kohei Takeuchi, Natsuki Kinoshita, Ryoto Urano, Rinka Nakajima, Yaxuan Zhou, Tokuo Kobayashi, Tadayoshi Hanyu, Kiyoshi Ohtani, Kimiharu Ambe, Keiko Kawauchi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101044- (2024)
Multinucleation occurs in various types of advanced cancers and contributes to their malignant characteristics, including anticancer drug resistance. Therefore, inhibiting multinucleation can improve cancer prognosis; however, the molecular mechanism
Externí odkaz:
https://doaj.org/article/f51ae573f0e7445cae640d305efa2a44
Autor:
Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani
Publikováno v:
Biology, Vol 12, Iss 12, p 1511 (2023)
The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of tumorigenesis. E2F fulfills a major role in cell proliferation by controlling a variety of growth-
Externí odkaz:
https://doaj.org/article/6ccef8f5458c4c6bb40ff2e7fd72d812
Autor:
Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Arlene Angelina, Yasuko Goto, Fumiya Tohjo, Kengo Nakahashi, Kimi Nakata, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Publikováno v:
Biochemical and Biophysical Research Communications. 663:154-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c835fc474bd66a129a4a4ebb672665d5
https://doi.org/10.1016/j.bbrc.2023.04.092
https://doi.org/10.1016/j.bbrc.2023.04.092
Autor:
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Publikováno v:
Genes. 14:393
The transcription factor E2F, the principal target of the tumor suppressor pRB, plays crucial roles in cell proliferation and tumor suppression. In almost all cancers, pRB function is disabled, and E2F activity is enhanced. To specifically target can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a841ddb5ddd0fead727b177d15d8c63a
https://doi.org/10.3390/genes14020393
https://doi.org/10.3390/genes14020393
Autor:
Andrew P. Bradford, Kiyoshi Ohtani, Kenta Kurayoshi, Eiko Ozono, Hideyuki Komori, Keigo Araki, Ritsuko Iwanaga, Yasuko Goto
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, respectively. It is generally accepted that E2F binds to target sequences with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628ae65415147e87cd99794c4617de9b
http://link.springer.com/article/10.1038/s41598-018-26860-0
http://link.springer.com/article/10.1038/s41598-018-26860-0
Autor:
Andrew P. Bradford, Eiko Ozono, Ritsuko Iwanaga, Ayumi Shiromoto, Kenta Kurayoshi, Kiyoshi Ohtani, Keigo Araki
Publikováno v:
Biochemical and Biophysical Research Communications. 483:107-114
In cancer treatment, specifically targeting cancer cells is important for optimal therapeutic efficacy. One strategy is to utilize a cancer specific promoter to express a cytotoxic gene or a viral gene required for replication. In this approach, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e8cdd92bd2b64b18943b594d44c1a8
https://doi.org/10.1016/j.bbrc.2016.12.185
https://doi.org/10.1016/j.bbrc.2016.12.185
Autor:
Kazuyuki Kugawa, Kenta Kurayoshi, Ritsuko Iwanaga, Junko Okuno, Andrew P. Bradford, Keigo Araki, Eiko Ozono, Kiyoshi Ohtani
Publikováno v:
Biochemical and Biophysical Research Communications. 482:784-790
The transcription factor E2F plays crucial roles in tumor suppression by activating pro-apoptotic genes such as the tumor suppressor ARF. The regulation of the ARF gene is distinct from that of growth-related E2F targets, in that it is specifically a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56b666467590bc9945800dfdee449c6
https://doi.org/10.1016/j.bbrc.2016.11.111
https://doi.org/10.1016/j.bbrc.2016.11.111
Publikováno v:
Journal of Molecular Biology. 428:4993-5006
The heterodimeric transcription factor E2F1-DP1 plays crucial roles in coordinating gene expression during G1/S cell cycle progression. For transcriptional activation, the transactivation domain (TAD) of E2F1 is known to interact with the TATA-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bad9be850d0903652f9ebb0f36c3f2
https://doi.org/10.1016/j.jmb.2016.11.001
https://doi.org/10.1016/j.jmb.2016.11.001
Autor:
Daisuke Tsuda, Kiyoshi Ohtani, Ryosuke Yoshida, Hiroya Oda, Keigo Araki, Wataru Sugimoto, Keiko Kawauchi
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Mitochondrial damage is caused by changes in the micro-environmental conditions during tumor progression. Cancer cells require mechanisms for mitochondrial quality control during this process; however, how mitochondrial integrity is maintained is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a32905721df4cdc341b5303bbefd35
https://doi.org/10.1038/s42003-018-0246-9
https://doi.org/10.1038/s42003-018-0246-9