Výsledky vyhledávání - "Kiyoshi Motokawa"

Novel Antibacterial Macrolides: Synthesis of 15-Membered Diolides

Autor: Yukitoshi Narukawa, Kiyoshi Motokawa, Kouichi Uotani, Hiroshi Nakai, Takafumi Ohara, Masaharu Kume

Publikováno v: The Journal of Organic Chemistry. 67:9146-9152

Novel 15-membered macrolides possessing the dilactone skeleton, diolides 13a and 13b, have been synthesized in our research program aimed at finding new antibacterial macrolides. Key strategic elements of the approach include the ring-expanding react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670da402465a7f4b2ab77a1f270ba8a5
https://doi.org/10.1021/jo020458e

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In Vitro Antibacterial Activity of a New Oral Cephalosporin, S-1090

Autor: Isao Higashiyama, Shimaru Sasaki, Masayoshi Doi, Kiyoshi Motokawa, Tadashi Yoshida, Hiroshi Nagata, Shogo Kuwahara, Yoshihide Komatsu, Kazuhisa Murakami

Publikováno v: Journal of Infection and Chemotherapy. 3:38-48

A new oral cephem antibiotic S-1090 was evaluated for its in vitro antibacterial activity in comparison with cefdinir, cefpodoxime, and cefaclor. S-1090 had fairly potent antibacterial activity when compared with cefdinir, cefpodoxime, and cefaclor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49e42d4426bac2e7f6e502e2033341e1
https://doi.org/10.1007/bf02489183

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A Novel 1.BETA.-Methylcarbapenem Antibiotic, S-4661.Synthesis and Structure-activity Relationships of 2-(5-Substituted Pyrrolidin-3-ylthio)-1.BETA.-methylcarbapenems

Autor: Kiyoshi Motokawa, Yasuyoshi Iso, Yasuhiro Nishitani, Yutaka Nishino, Tadashi Irie

Publikováno v: The Journal of Antibiotics. 49:199-209

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1- methylcarbapen-2-em-3-carboxylic acids are described. These compounds exhibit potent antibacterial activity against a wide ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37faf3acae52616004bb701fd12e2be3
https://doi.org/10.7164/antibiotics.49.199

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ChemInform Abstract: Orally Active Cephalosporins. Part 1. Synthesis and Structure-Activity Relationships of 7β-(2-(R)-Amino-2-phenylacetamido)-3-(1H-1,2,3- triazol-4-yl)alkylthiomethyl -3-cephem-4-carboxylic Acid and Related Compounds

Autor: Kiyoshi Motokawa, Y. Kimura, H. Nakashimizu, M. Kume, Tadatoshi Kubota

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b302a9277c7b1792b547e573c104638
https://doi.org/10.1002/chin.199350311

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ChemInform Abstract: Quantitative Structure-Activity Relationships of Antibacterial Agents, 7-Heterocyclic Amine Substituted 1-Cyclopropyl-6,8-difluoro-4- oxoquinoline-3-carboxylic Acids

Autor: Teruji Tsuji, Kiyoshi Motokawa, Hisao Sato, Tadahiko Tsushima, Kiyoshi Ezumi, Tetsuo Okada, Yoshihide Komatsu, Masumi Yamakawa

Publikováno v: ChemInform. 24

Quantitative structure-activity relationships (QSAR) of various 7-(3-substituted-azetidin-1-yl)-1-cyclopropyl-6,8-difluoro-1,4-dih ydro-4- oxoquinoline-3-carboxylic acids, 14-25, were studied to clarify the structural requirements for 3-substituted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0d30498d067cf4de3bee9289429ef2
https://doi.org/10.1002/chin.199325281

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of 7β-((Z)-2-(2- Aminothiazol-4-yl)-3-(substituted)-2-propenoylamino)-3- desacetoxymethylcephalosporins

Autor: H. Nakashimizu, Kyoji Minami, T. Yoshida, Koji Ishikura, Kiyoshi Motokawa, Tadatoshi Kubota, Yoshio Hamashima

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78cd6503a42bbaf2aca92720f9316709
https://doi.org/10.1002/chin.199441220

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of 7β-((Z)-2-(2- Aminothiazol-4-yl)-3-(substituted)-2-propenoylamino)-3-cephems with C- 3 Substitutions

Autor: Hideaki Miwa, Kyoji Minami, Koji Ishikura, T. Yoshida, Kiyoshi Motokawa, Tadatoshi Kubota, H. Nakashimizu, Y. Kimura, Yoshio Hamashima

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::727bbcd241e828d7fbee81802bdd9ed1
https://doi.org/10.1002/chin.199441221

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ChemInform Abstract: Orally Active Cephalosporins. Part 4. Synthesis, Antibacterial Activity, and Oral Absorption of 3-(1H-1,2,3-Triazol-4-yl) thiomethylthiocephalosporins

Autor: Kiyoshi Motokawa, H. Nakashimizu, M. Kume, Y. Kimura, Tadatoshi Kubota

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172622ccc18ec6b4bf47ab6b2b3ba277
https://doi.org/10.1002/chin.199506251

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ChemInform Abstract: A Novel 1β-Methylcarbapenem Antibiotic, S-4661. Synthesis and Structure-Activity Relationships of 2-(5-Substituted Pyrrolidin-3- ylthio)-1β-methylcarbapenems

Autor: Y. Nishino, Kiyoshi Motokawa, Yasuyoshi Iso, Yasuhiro Nishitani, Tadashi Irie

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65eb700811665a29cfd3a12843dff340
https://doi.org/10.1002/chin.199632297

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Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661

Autor: Kiyoshi Motokawa, Yasuhiro Nishitani, Yuji Sendo, Makoto Kii, Yasuyoshi Iso, Tsutomu Iwaki, Tadashi Irie

Publikováno v: The Journal of antibiotics. 49(5)

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05342533b75d85b24c9547698cc7f14b
https://pubmed.ncbi.nlm.nih.gov/8682725

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