Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kiyoshi Mizuguchi"'
Autor:
Kiyoshi Mizuguchi, Hitoshi Shimano, Hiroyuki Kawano, Masanori Nakakuki, Kazunori Imada, Tatsuto Notsu
Publikováno v:
The Journal of Biochemistry. 155:301-313
The proteolytic cascade is the key step in transactivation of sterol regulatory element-binding proteins (SREBPs), a transcriptional factor of lipid synthesis. Proteolysis of SREBP-2 is strictly regulated by sterols, but that of SREBP-1c was not stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63ee7a686f70216763601e9c5cde6c2
https://doi.org/10.1093/jb/mvu019
https://doi.org/10.1093/jb/mvu019
Autor:
Bing Xu, Kiyoshi Mizuguchi, Kaoruko Yamanaka, Izumi Kusuki, Yutaka Shimizu, Izumi Suganuma, Shizuka Mita, Jo Kitawaki
Publikováno v:
Fertility and Sterility. 97:477-482
Objective To determine the effect of dienogest (DNG) on the expression of aromatase and cyclooxygenase-2 (COX-2) and the production of prostaglandin E 2 (PGE 2 ) in human endometriotic stromal cells (ESCs). Design Experimental study in vitro. Setting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f0fabc7c36afcd6f2f0afd1867f4364
https://doi.org/10.1016/j.fertnstert.2011.11.005
https://doi.org/10.1016/j.fertnstert.2011.11.005
Autor:
Osamu Takase, Toshiro Fujita, Keiichi Hishikawa, Kiyoshi Mizuguchi, Masanori Nakakuki, Nozomu Kamiura, Hiroyuki Kawano
Publikováno v:
European Journal of Pharmacology. 669:128-135
Fish oil containing n-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is well known to prevent the progression of IgA nephropathy. However, the mechanism through which fish oil prevents the progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f1585918e46a8091630dcb1d0eee41
https://doi.org/10.1016/j.ejphar.2011.07.043
https://doi.org/10.1016/j.ejphar.2011.07.043
Publikováno v:
Steroids. 76:60-67
Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a7385bfd03a2b6a8374ba0e101b9ee
https://doi.org/10.1016/j.steroids.2010.08.010
https://doi.org/10.1016/j.steroids.2010.08.010
Autor:
Akiko Kawashima, Satoshi Kajikawa, Kazunori Imada, Takashi Takeuchi, Yutaka Shimizu, Kiyoshi Mizuguchi, Tsuyoshi Harada
Publikováno v:
Digestive Diseases and Sciences. 56:1065-1074
Nonalcoholic steatohepatitis (NASH) is associated with fat accumulation in the liver, and develops to cirrhosis with the progression of hepatic fibrosis. Eicosapentaenoic acid (EPA) is used to treat hyperlipidemia, and suppresses hepatic fat accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8efe30e36de74f733926a9c550fc0a
https://doi.org/10.1007/s10620-010-1400-5
https://doi.org/10.1007/s10620-010-1400-5
Autor:
Masanori Nakakuki, Hiroyuki Kawano, Michiko Itoh, Ayumi Sato, Kiyoshi Mizuguchi, Yoshihiro Ogawa, Masahiko Ohta, Takayoshi Suganami, Tatsuto Notsu
Publikováno v:
Diabetes. 59:2495-2504
OBJECTIVE Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct models of obesity. RESEARCH DESIGN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc7e67d5f9811a7ac01f8445093c157
https://doi.org/10.2337/db09-1554
https://doi.org/10.2337/db09-1554
Publikováno v:
Journal of Endocrinological Investigation. 33:745-750
Activation of the progesterone receptor (PR) inhibits cell proliferation in various reproductive tissues. However, the molecular mechanisms underlying the regulation of cell proliferation by PR remain poorly understood. It is well established that Kr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c43f73a9c968716ff83e26ac7607fb1
https://doi.org/10.1007/bf03346681
https://doi.org/10.1007/bf03346681
Autor:
Hideaki Kami, Akiko Kawashima, Tsuyoshi Harada, Kiyoshi Mizuguchi, Takashi Yano, Kazunori Imada
Publikováno v:
The Journal of Nutritional Biochemistry. 21:268-277
Placebo-controlled clinical studies suggest that intake of n-3 polyunsaturated fatty acids improves neurological disorders such as Alzheimer's disease, Huntington's disease and schizophrenia. To evaluate the impact of eicosapentaenoic acid (EPA), we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c676d6509ee9b44f6e425bfd8347080
https://doi.org/10.1016/j.jnutbio.2008.12.015
https://doi.org/10.1016/j.jnutbio.2008.12.015
Autor:
Osamu Shido, Kiyoshi Mizuguchi, Tsuyoshi Harada, Takashi Yano, Yoko Tanabe, Michio Hashimoto, Shahdat Hossain, Akiko Kawashima
Publikováno v:
The Journal of nutritional biochemistry. 20(12):965-973
Background Amyloid β (Aβ) peptide (1–40) can cause cognitive impairment. Experimental design We investigated whether dietary preadministration of eicosapentaenoic acid (EPA) is conducive to cognition learning ability and whether it protects again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fcfb056b0d6023f0d01c2869c27c32
http://ir.lib.shimane-u.ac.jp/52095
http://ir.lib.shimane-u.ac.jp/52095
Publikováno v:
Folia Pharmacologica Japonica. 133:32-40
ジエノゲスト（販売名：ディナゲスト錠1 mg）は，プロゲステロン受容体に対して選択的なアゴニスト活性を示す第4世代のプロゲスチンである．ジエノゲストは，ラットおよびウサギに
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10acd909b271bb314f01e027d84e7db9
https://doi.org/10.1254/fpj.133.32
https://doi.org/10.1254/fpj.133.32