Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kiyoshi Inoguchi"'
Autor:
Motonori Miyakawa, Noriko Yamamoto, Naoya Nagata, Kazuyuki Furuya, Kiyoshi Inoguchi, Seiji Amano, Hiroaki Nejishima
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6310-6313
A rationally designed tetrahydroquinoline (1) for nonsteroidal selective androgen receptor modulators was modified for the exploration of promising compounds by Grieco three-component condensation using various dienophiles. Based on the in vitro effe
Autor:
Hisato Senda, Kiyoshi Inoguchi, Takashi Ikari, Tetsuo Shibata, Nobuko Itoh, Noriyuki Kamei, Masanao Shimano
Publikováno v:
Tetrahedron. 54:12745-12774
The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute config
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 33
The reaction of N-protected 3-pyrrolidone and 4-piperidone with N,N-dimethylformamide dimethyl acetal gave the dimethylaminomethylene ketones, which reacted with several types of hydrazines, amidines, and guanidine to afford the secondary amines havi
Publikováno v:
Synlett. 1992:169-178
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:2921-2926
A new chiral 1, 3-bisphosphine, (1R, 2R)-1-diphenylphosphino-2-(diphenylphosphinomethyl)cyclopentane, which was designed to form the favorable skew conformation of the six-membered chelate with rhodium, was developed. Its rhodium complex was found to
Autor:
Tatsuya Maruyama, Satoru Ikegami, Yoichiro Hoshina, Akinori Aoyama, Hideto Fukui, Tsutomu Nakamura, Kiyoshi Inoguchi, Tatsuhiro Harada, Kyoko Fujimoto, Akihiko Okuyama, Hiroshi Tanaka, Yuzuru Matsumura
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(1)
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7 nM, and has good