Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Kiyoshi, Yamaguchi"'
Autor:
Wenwen Wu, Jing Zhu, Naoe Taira Nihira, Yukiko Togashi, Atsushi Goda, Junki Koike, Kiyoshi Yamaguchi, Yoichi Furukawa, Takuya Tomita, Yasushi Saeki, Yoshikazu Johmura, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Epigenetic dysregulation affecting oncogenic transcription and DNA damage response is a hallmark of cancer. The histone demethylase KDM4B, a factor regulating these processes, plays important roles in estrogen receptor-mediated tr
Externí odkaz:
https://doaj.org/article/495f1b5e342f41eeacc7052e5521f4b0
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Erica Carolina, Yoshiki Kuse, Ayumu Okumura, Kenji Aoshima, Tomomi Tadokoro, Shinya Matsumoto, Eriko Kanai, Takashi Okumura, Toshiharu Kasai, Souichiro Yamabe, Yuji Nishikawa, Kiyoshi Yamaguchi, Yoichi Furukawa, Naoki Tanimizu, Hideki Taniguchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract In fetal development, tissue interaction such as the interplay between blood vessel (BV) and epithelial tissue is crucial for organogenesis. Here we recapitulate the spatial arrangement between liver epithelial tissue and the portal vein to
Externí odkaz:
https://doaj.org/article/ca9c0a20ba1b470087e8cfaaff27dd50
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Deregulation of the Wnt/β-catenin pathway is associated with the development of human cancer including colorectal and liver cancer. Although we previously showed that histidine ammonia lyase (HAL) was transcriptionally reduced by the β-cat
Externí odkaz:
https://doaj.org/article/cfe714ca98a74825ba13266f4890aa9e
Autor:
Xinyi Zeng, Teh-Wei Wang, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshikazu Johmura, Makoto Nakanishi
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101943- (2024)
Objectives: Adipose tissue is an endocrine and energy storage organ composed of several different cell types, including mature adipocytes, stromal cells, endothelial cells, and a variety of immune cells. Adipose tissue aging contributes to the pathog
Externí odkaz:
https://doaj.org/article/d4df8a00e52b49dc89a15ccb72df509b
Autor:
Noritaka Tanaka, Hikari Okada, Kiyoshi Yamaguchi, Masahide Seki, Daisuke Matsubara, Noriko Gotoh, Yutaka Suzuki, Yoichi Furukawa, Taro Yamashita, Jun-ichiro Inoue, Shuichi Kaneko, Takeharu Sakamoto
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-12 (2023)
Abstract Given the lack of therapeutic targets, the conventional approach for managing triple-negative breast cancer (TNBC) involves the utilization of cytotoxic chemotherapeutic agents. However, most TNBCs acquire resistance to chemotherapy, thereby
Externí odkaz:
https://doaj.org/article/bb2d8ae7e71c4a039d982e2c5ef19671
Autor:
Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113918- (2024)
Summary: Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs con
Externí odkaz:
https://doaj.org/article/c85fa5cd49224938abb19488da79baeb
Autor:
Hiroki Tage, Kiyoshi Yamaguchi, Saya Nakagawa, So Kasuga, Kiyoko Takane, Yoichi Furukawa, Tsuneo Ikenoue
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13426-13437 (2023)
Abstract Background Abnormal activation of Wnt/β‐catenin signaling is associated with various aspects of cancer development. This study explored the roles of novel target genes of the Wnt/β‐catenin signaling pathway in cancer cells. Methods Usi
Externí odkaz:
https://doaj.org/article/87f8dda8e3a84514b88a7f8bda927985
Autor:
Kota Washimi, Rika Kasajima, Eigo Shimizu, Shinya Sato, Yoichiro Okubo, Emi Yoshioka, Hiroto Narimatsu, Toru Hiruma, Kotoe Katayama, Rui Yamaguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Tomoyuki Yokose, Yohei Miyagi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Myxofibrosarcoma (MFS) and undifferentiated sarcoma (US) have been considered as tumors of the same lineage based on genetic/epigenetic profiling. Although MFS shows a notably better prognosis than US, there are no clear criteria for disting
Externí odkaz:
https://doaj.org/article/f8c48a501cdd40eab902075a4f8a951f
Autor:
Kenta Takeuchi, Shunsuke Tabe, Kenta Takahashi, Kenji Aoshima, Megumi Matsuo, Yasuharu Ueno, Yoichi Furukawa, Kiyoshi Yamaguchi, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113420- (2023)
Summary: The aggressiveness of pancreatic ductal adenocarcinoma (PDAC) is affected by the tumor microenvironment (TME). In this study, to recapitulate the PDAC TME ex vivo, we cocultured patient-derived PDAC cells with mesenchymal and vascular endoth
Externí odkaz:
https://doaj.org/article/60c92d8cab9240c1b5e205b61ce0efa4