Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kiyoshi, Oketani"'
Autor:
Toshinori Katsurabara, Seiichiro Hojo, Makoto Naganuma, Katsuyoshi Matsuoka, Toshifumi Hibi, Takanori Kanai, Osamu Takenaka, Hirohito Tsubouchi, Tetsu Kawano, Kiyoshi Oketani, Toshio Imai
Publikováno v:
Journal of Gastroenterology and Hepatology
Background and Aim E6011 is a humanized monoclonal antibody targeting fractalkine (FKN), a CX3C chemokine, which regulates leukocyte trafficking during inflammation. We evaluated the safety and pharmacokinetic profile of E6011 in patients with Crohn'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb34466c000a83b02d7dee0dc0aab4f
http://europepmc.org/articles/PMC8451784
http://europepmc.org/articles/PMC8451784
Autor:
Seiichiro Hojo, Toshifumi Hibi, Makoto Arai, Hiroko Nebiki, Osamu Takenaka, Akio Ido, Fukunori Kinjo, Motohiro Esaki, Satoshi Tanida, Toshiyuki Matsui, Takayuki Matsumoto, Toshio Imai, Kiyoshi Oketani, Noriyuki Horiki, Mikihiro Fujiya, Masayuki Saruta, Keiichi Mitsuyama, Kazuya Kitamura, Katsuyoshi Matsuoka, Makoto Naganuma, Takako Miyazaki, Hirohito Tsubouchi, Takanori Kanai
Publikováno v:
Gastroenterology. 154:S-830
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1acd55478701bfb4856dfb678c044b0
https://doi.org/10.1016/s0016-5085(18)32827-0
https://doi.org/10.1016/s0016-5085(18)32827-0
Autor:
Hideki Sakai, Takaoki Uchiumi, Manabu Murakami, Kiyoshi Oketani, Tomoyuki Suzuki, Noriaki Takeguchi, Miki Murota
Publikováno v:
British Journal of Pharmacology. 136:383-390
E3040 (6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole), is a novel dual inhibitor of 5-lipoxygenase (5-LOX) and thromboxane synthase (Tx synthase). Here, we examined the effects of E3040 sulphate, a sulphate conjugate of E3040,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da26d090914ab31d6689a6eae61d3bc0
https://doi.org/10.1038/sj.bjp.0704723
https://doi.org/10.1038/sj.bjp.0704723
Publikováno v:
European Journal of Pharmacology. 427:159-166
Intravenous administration of lipopolysaccharide to rats that had been immunized with lipopolysaccharide induced hemorrhagic damage in the large intestine. We investigated the role of 5-lipoxygenase and thromboxane synthase products in the damage of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7804d3f8a28cb2117d6e7f63976314aa
https://doi.org/10.1016/s0014-2999(01)01234-1
https://doi.org/10.1016/s0014-2999(01)01234-1
Publikováno v:
Japanese Journal of Pharmacology. 76:279-288
The effects of rabeprazole (E3810), omeprazole and chloroquine on hepatic lysosomal function were studied. After chloroquine (50 mg/kg), rabeprazole (5 mg/kg) or omeprazole (5 mg/kg) was given intraperitoneally to rats for 6 days, the bile was collec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642491d1e1d144bda31ae00b3d9881e7
https://doi.org/10.1254/jjp.76.279
https://doi.org/10.1254/jjp.76.279
Autor:
Keiichi Mitsuyama, Toshifumi Hibi, Kazuya Kitamura, Masaki Iimuro, Katsuyoshi Matsuoka, Satoshi Tanida, Noriyuki Horiki, Takanori Kanai, Hirohito Tsubouchi, Hiroko Nebiki, Toshiyuki Matsui, Makoto Arai, Seiichiro Hojo, Fukunori Kinjo, Motohiro Esaki, Makoto Naganuma, Toshio Imai, Masayuki Saruta, Kiyoshi Oketani, Mikihiro Fujiya, Hideto Akama, Takayuki Matsumoto
Publikováno v:
Gastroenterology. 150:S808
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86461f84ab1f59414f22a8466258ac1
https://doi.org/10.1016/s0016-5085(16)32732-9
https://doi.org/10.1016/s0016-5085(16)32732-9
Autor:
Hideaki Fujisaki, Noriaki Takeguchi, Tsuneo Wakabayashi, Masatoshi Fujimoto, Isao Yamatsu, Manabu Murakami, Hisashi Shibata, Kiyoshi Oketani
Publikováno v:
Drug Investigation. 3:328-332
The effects of E3810, a potent proton pump inhibitor, on gastric secretion and gastric or duodenal ulcers or erosions were studied in rats. Intraduodenal administration of E3810 dose dependently inhibited gastric secretion (volume and acid outputs) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3bedf565fbfebd2f909e9257ef48e9
https://doi.org/10.1007/bf03259747
https://doi.org/10.1007/bf03259747
Autor:
Hideki Sakai, Isao Yamatsu, Hideaki Fujisaki, Tsuneo Wakabayashi, Masatoshi Fujimoto, Makoto Yamaguchi, Hisashi Shibata, Kiyoshi Oketani, Noriaki Takeguchi, Manabu Murakami
Publikováno v:
Biochemical Pharmacology. 42:321-328
A substituted benzimidazole ([4-(3-methoxypropoxy)-3-methylpyridine-2-yl]methylsulfinyl)- 1H-benzimidazole sodium salt (E3810), is a gastric proton pump (H+, K(+)-ATPase) inhibitor. E3810 and omeprazole inhibited acid accumulation dose dependently as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965522c5435139f5cf25c679ca16a10c
https://doi.org/10.1016/0006-2952(91)90719-l
https://doi.org/10.1016/0006-2952(91)90719-l
Autor:
Hideki, Sakai, Tomoyuki, Suzuki, Miki, Murota, Kiyoshi, Oketani, Takaoki, Uchiumi, Manabu, Murakami, Noriaki, Takeguchi
Publikováno v:
British journal of pharmacology. 136(3)
1. E3040 (6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole), is a novel dual inhibitor of 5-lipoxygenase (5-LOX) and thromboxane synthase (Tx synthase). Here, we examined the effects of E3040 sulphate, a sulphate conjugate of E30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a58a1660007b93c041b686792429e8cf
https://pubmed.ncbi.nlm.nih.gov/12023941
https://pubmed.ncbi.nlm.nih.gov/12023941
Publikováno v:
European journal of pharmacology. 422(1-3)
In vitro pharmacological profiles of E3040, 6-hydroxy-5, 7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl) benzothiazole were investigated. Against the 5-lipoxygenase activity of rat basophilic leukemia cells, E3040 and zileuton (a 5-lipoxygenase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7195f4bf44eddba7925df04e3cfcf06
https://pubmed.ncbi.nlm.nih.gov/11430933
https://pubmed.ncbi.nlm.nih.gov/11430933