Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Kiyoshi, Isobe"'
Autor:
Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Hideaki Tagashira, Takahiro Iwamoto, Akihito Ohta, Kiyoshi Isobe, Takayasu Mori, Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235360 (2020)
The sodium (Na+)-chloride cotransporter (NCC) expressed in the distal convoluted tubule (DCT) is a key molecule regulating urinary Na+ and potassium (K+) excretion. We previously reported that high-K+ load rapidly dephosphorylated NCC and promoted ur
Externí odkaz:
https://doaj.org/article/d2729c341b9d4e17acb6dfd724a6bd1b
Autor:
Yuya Araki, Tatemitsu Rai, Eisei Sohara, Takayasu Mori, Yuichi Inoue, Kiyoshi Isobe, Eriko Kikuchi, Akihito Ohta, Sei Sasaki, Shinichi Uchida
Publikováno v:
Biology Open, Vol 4, Iss 11, Pp 1509-1517 (2015)
Pseudohypoaldosteronism type II (PHAII) is a hereditary hypertensive disease caused by mutations in four different genes: with-no-lysine kinases (WNK) 1 and 4, Kelch-like family member 3 (KLHL3), and cullin 3 (Cul3). Cul3 and KLHL3 form an E3 ligase
Externí odkaz:
https://doaj.org/article/f4196a8ec45b45e7a02c95a20ffd8c83
Autor:
Mai Wakabayashi, Takayasu Mori, Kiyoshi Isobe, Eisei Sohara, Koichiro Susa, Yuya Araki, Motoko Chiga, Eriko Kikuchi, Naohiro Nomura, Yutaro Mori, Hiroshi Matsuo, Tomohiro Murata, Shinsuke Nomura, Takako Asano, Hiroyuki Kawaguchi, Shigeaki Nonoyama, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 858-868 (2013)
Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identifi
Externí odkaz:
https://doaj.org/article/ba91c88e7dd644f3b76a03cb844e069c
Autor:
Chung-Lin Chou, Laya Krishnan, Kiyoshi Isobe, Viswanathan Raghuram, Chin-Rang Yang, Mark A. Knepper
Publikováno v:
Am J Physiol Renal Physiol
Prior studies have implicated myosin light chain kinase (MLCK) in the regulation of aquaporin-2 (AQP2) in the renal collecting duct. To discover signaling targets of MLCK, we used CRISPR-Cas9 to delete the MLCK gene ( Mylk) to obtain MLCK-null mpkCCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92bd19fb34f4c062b31a5e29a7aa723
https://doi.org/10.1152/ajprenal.00431.2019
https://doi.org/10.1152/ajprenal.00431.2019
Autor:
Yosuke, Mihara, Takashi, Ando, Masanori, Hayashi, Koji, Atsuta, Takamori, Nakayama, Kiyoshi, Isobe
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 49(1)
A man in his 70s was observed to have GIST recurrence 19 months after surgery. Chemotherapy was initiated with imatinib 400 mg/day orally. The dose was eventually reduced to 100 mg/day to avoid side effects. Tumor reduction was confirmed 3 months aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55499ac3335b85de4b4551f2ce9f335b
https://pubmed.ncbi.nlm.nih.gov/35046364
https://pubmed.ncbi.nlm.nih.gov/35046364
Autor:
Shinichi Uchida, Tamami Fujiki, Fumiaki Ando, Kana Murakami, Naohiro Nomura, Takayasu Mori, Tatemitsu Rai, Kiyoshi Isobe, Eisei Sohara, Koichiro Susa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Tolvaptan, a vasopressin type 2 receptor antagonist initially developed to increase free-water diuresis, has been approved for the treatment of autosomal dominant polycystic kidney disease in multiple countries. Furthermore, tolvaptan has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7567b82288dee5bb078885ac12dea4
http://link.springer.com/article/10.1038/s41598-019-45539-8
http://link.springer.com/article/10.1038/s41598-019-45539-8
Autor:
Keiko Nagahara MD, PhD, Yoshifusa Abe MD, PhD, Akira Hojo MD, Kazushige Dobashi MD, PhD, Motoko Chiga, Kiyoshi Isobe MD, PhD, Shinichi Uchida MD, PhD, Kazuo Itabashi MD, PhD
Publikováno v:
Global Pediatric Health, Vol 1 (2014)
Externí odkaz:
https://doaj.org/article/47820263a93948c7aa86ddc1099c4d7a
Autor:
Eriko Kikuchi, Hiroyuki Masuno, Takayasu Mori, Yuko Watanabe, Shinichi Uchida, Hiroyuki Kagechika, Kiyoshi Isobe, Honoka Suzuyama, Shinya Fujii, Mari Ishigami-Yuasa
Publikováno v:
ChemMedChem. 16(18)
Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6351eaf79a451096fa24aa3836b0a232
https://pubmed.ncbi.nlm.nih.gov/34109743
https://pubmed.ncbi.nlm.nih.gov/34109743
Autor:
Tatemitsu Rai, Takahiro Iwamoto, Shinichi Uchida, Hideaki Tagashira, Koichiro Susa, Kiyoshi Isobe, Eisei Sohara, Wakana Shoda, Naohiro Nomura, Akihito Ohta, Takayasu Mori, Fumiaki Ando
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0235360 (2020)
PLoS ONE, Vol 15, Iss 6, p e0235360 (2020)
The sodium (Na+)-chloride cotransporter (NCC) expressed in the distal convoluted tubule (DCT) is a key molecule regulating urinary Na+ and potassium (K+) excretion. We previously reported that high-K+ load rapidly dephosphorylated NCC and promoted ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60031e3d309aee5f265742359e12b010
http://europepmc.org/articles/PMC7326190
http://europepmc.org/articles/PMC7326190
Autor:
Masao Kasahara, Takamori Nakayama, Kou Shiraishi, Takashi Ando, Takahiro Suzuki, Koji Atsuta, Kiyoshi Isobe
Publikováno v:
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 80:341-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bb10fb373793a811c55d9da90e5d8f
https://doi.org/10.3919/jjsa.80.341
https://doi.org/10.3919/jjsa.80.341