Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kiyoshi, Furuichi"'
Autor:
Kiyoshi Furuichi, Takao Suzuki, Maki Moritani, Masahiko Akamatsu, Kouichi Nishimura, Masayasu Yoshino, Masato Kobori, Mitsuhiro Kagami, Mitsuo Itakura, Shoji Iwasaki, Hitoshi Matsushime, Masao Kotoh
Publikováno v:
Mammalian Genome. 19:15-25
When the homozygous active form of porcine TGF-beta1 transgene (Tgf/Tgf) (under control of the rat glucagon promoter) is introduced into the nonobese diabetic mouse (NOD) genetic background, the mice develop endocrine and exocrine pancreatic hypoplas
Autor:
Ayako Matsuo, Mamoru Nagano, Masazumi Kamohara, Masato Kobori, Masao Katoh, Shunichiro Matsumoto, Kiyoshi Furuichi, Hideki Hiyama, Yasufumi Shigeyoshi, Mitsuyuki Matsumoto, Hitoshi Matsushime, Chihiro Yamazaki, Takatoshi Soga, Koh-hei Masumoto, Masanori Naito, Jun Takasaki, Hiroyuki Ishii
Publikováno v:
Proceedings of the National Academy of Sciences. 103:4140-4145
Prokineticins, multifunctional secreted proteins, activate two endogenous G protein-coupled receptors PKR1 and PKR2. From in situ analysis of the mouse brain, we discovered that PKR2 is predominantly expressed in the olfactory bulb (OB). To examine t
Autor:
Takahide Ohishi, Hitoshi Matsushime, Tetsu Saito, Takatoshi Soga, Masazumi Kamohara, Kiyoshi Furuichi, Masato Kobori, Mitsuyuki Matsumoto, Shunichiro Matsumoto, Hideki Hiyama, Jun Takasaki, Tetsuo Matsui, Kazuhiro Momose, Yoshitaka Ueda, Shigeru Yoshida
Publikováno v:
Biochemical and Biophysical Research Communications. 326:744-751
A lysophospholipid series, such as lysophosphatidic acid, lysophosphatidylserine, and lysophosphatidylcholine (LPC), is a bioactive lipid mediator with diverse physiological and pathological functions. LPC has been reported to induce insulin secretio
Autor:
Adrian R. Krainer, Hiroshi Kimura, Kengo Sumi, Tomonobu Koizumi, Jun Koizumi, Kiyoshi Furuichi, Michael V. Murray, Hiroshi Shibuya, Jun-ichiro Yomoda, Masatoshi Hagiwara, Hiroshi Onogi, Michiko Muraki, Masaaki Suzuki, Bisei Ohkawara, Takamitsu Hosoya
Publikováno v:
Journal of Biological Chemistry. 279:24246-24254
The regulation of splice site usage provides a versatile mechanism for controlling gene expression and for the generation of proteome diversity, playing an essential role in many biological processes. The importance of alternative splicing is further
Autor:
Michel Lazdunski, John P. Adelman, Gary V. Desir, Jonathan Robbins, Stephan Grissmer, Heike Wulff, Gail A. Robertson, Manuel Covarriubias, Douglas A. Bayliss, David McKinnon, Bernardo Rudy, Henry A. Lester, Andreas Karschin, Aguan Wei, David E. Clapham, Kiyoshi Furuichi, Maria L. Garcia, Randy S. Wymore, Barry Ganetzky, K. George Chandy, Michael C. Sanguinetti, Lily Yeh Jan, Jayashree Aiyar, Yoshihisa Kurachi, Walter Stuehmer, Florian Lesage, Colin G. Nichols, Ita O'Kelly, Sabina Kuperschmidt, Michael M. Tamkun, George A. Gutman, Susumu Seino, Carol A. Vandenberg, Donghee Kim
Publikováno v:
Pharmacological Reviews. 55:575-578
This summary article presents an overview of the molecular relationships among the voltage-gated sodium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium,
Autor:
Kohei Inamura, Hitoshi Matsushime, Kiyoshi Furuichi, Hidetsugu Okada, Yorikata Sano, Chika Kitada, Hiromichi Yokoi, Akira Miyake, Katsura Nozawa, Shinobu Mochizuki
Publikováno v:
Journal of Biological Chemistry. 278:27406-27412
To find a novel human ion channel gene we have executed an extensive search by using a human genome draft sequencing data base. Here we report a novel two-pore domain K+ channel, TRESK (TWIK-related spinal cord K+ channel). TRESK is coded by 385 amin
Autor:
and Akira Matsuda, Kentaro Natsume, Kazufumi Hirano, Kiyoshi Furuichi, § Shun-ichiro Matsumoto, Ryohei Kimura, Shizuo Yamada, Satoshi Shuto, Yuji Kazuta
Publikováno v:
Journal of Medicinal Chemistry. 46:1980-1988
A series of cyclopropane-based conformationally restricted analogues of histamine, the "folded" cis-analogues, i.e., (1S,2R)-2-(aminomethyl)-1-(1H-imidazol-4-yl)cyclopropane (11), (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane (13), and th
Autor:
Masazumi Kamohara, Kiyoshi Furuichi, Takatoshi Soga, Hideki Hiyama, Takahide Ohishi, Shun Ichiro Matsumoto, Tamaki Oda, Jun Takasaki, Tetsu Saito, Hitoshi Matsushime
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1579:173-179
Recent studies have identified two novel biofunctional proteins, termed prokineticin 1/EG-VEGF and prokineticin 2, which were mammalian homologues of mamba MIT1 and frog Bv8. Prokineticins have been demonstrated to exert their physiological functions
Autor:
Kiyoshi Furuichi, Chika Kitada, Shinobu Mochizuki, Hitoshi Matsushime, Hiromichi Yokoi, Kohei Inamura, Katsura Nozawa, Yorikata Sano, Akira Miyake
Publikováno v:
FEBS Letters. 512:230-234
We report identification and characterization of Kv6.3, a novel member of the voltage-gated K+ channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indi
Autor:
Tetsu Saito, Jun Takasaki, Kiyoshi Furuichi, Masazumi Kamohara, Hitoshi Matsushime, Takatoshi Soga, Shunichiro Matsumoto, Mitsuyuki Matsumoto
Publikováno v:
Biochemical and Biophysical Research Communications. 287:1088-1092
Cysteinyl leukotrienes (LTC(4), LTD(4), and LTE(4)) are a class of biologically active lipids that exert potent effects on the heart. To assess their roles, we investigated the distribution of their receptors, CysLT(1) and CysLT(2), in the cardiovasc