Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kiyoshi, Egami"'
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 3, Pp 249-257 (2007)
The paroxysmal dyskinesias are a group of neurological disorders described by intermittent attacks of involuntary abnormal movements superimposed on a relatively normal baseline. The neuroanatomical substrates for these attacks are not fully understo
Externí odkaz:
https://doaj.org/article/094a485c49ef423a931c9f3b32ee6159
Autor:
Kiyoshi Egami, Silaja Yitta, Suhail Kasim, J. Chris Lewers, Rosalinda C. Roberts, Mohamed Lehar, H.A. Jinnah
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 2, Pp 396-407 (2007)
Several rare inherited disorders have provided valuable experiments of nature highlighting specific biological processes of particular importance to the survival or function of midbrain dopamine neurons. In both humans and mice, deficiency of hypoxan
Externí odkaz:
https://doaj.org/article/8ddd82f90ce24391a860402a2830be48
Autor:
Kristy J. Bruno, Christopher S. Freet, Robert C. Twining, Kiyoshi Egami, Patricia S. Grigson, Ellen J. Hess
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 1, Pp 206-216 (2007)
Attention deficit hyperactivity disorder (ADHD) is characterized by hyperactivity, inattention, and impulsivity. The coloboma mouse model of ADHD exhibits profound hyperactivity. To determine whether coloboma mice exhibit other signs of ADHD, we asse
Externí odkaz:
https://doaj.org/article/4e78136a875d421499575ba354ca9573
Autor:
Xiaokun Shu, Frances M. Brodsky, Kiyoshi Egami, James W. Maas, Tsz-Leung To, Cedric S. Asensio, Robert H. Edwards, Daniel W. Sirkis, Yifan Cheng
Publikováno v:
Developmental cell, vol 27, iss 4
The regulated release of polypeptides has a central role in physiology, behavior, and development, but the mechanisms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release have remained poorly understood. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbde7ce185a256761da6638dd80b5c5
https://doi.org/10.1016/j.devcel.2013.10.007
https://doi.org/10.1016/j.devcel.2013.10.007
Autor:
Brooke M. Gardner, Yifan Cheng, Jon M. Levy, Eliezer Masliah, Larissa A. Munishkina, Kiyoshi Egami, Gaia Skibinski, Steven Finkbeiner, Robert H. Edwards, Jue Zhang, Ken Nakamura, Farnaz Azarbal, Hiromi Sesaki, Junko Wakabayashi, Venu M. Nemani, Robert L. Nussbaum
Publikováno v:
Journal of Biological Chemistry. 286:20710-20726
The protein α-synuclein has a central role in Parkinson disease, but the mechanism by which it contributes to neural degeneration remains unknown. We now show that the expression of α-synuclein in mammalian cells, including neurons in vitro and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a5e3470eae96880d13b99be2fbc6f1
https://doi.org/10.1074/jbc.m110.213538
https://doi.org/10.1074/jbc.m110.213538
Autor:
Irène Ceballos-Picot, Lionel Mockel, Hyder A. Jinnah, J.C. Lewers, Thomas L. Shirley, Kiyoshi Egami
Publikováno v:
Neuroscience. 152:761-772
A unique sensitivity to specific biochemical processes is responsible for selective vulnerability of midbrain dopamine neurons in several diseases. Prior studies have shown these neurons are susceptible to energy failure and mitochondrial dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc749d46a800a95509d254d745c236a8
https://doi.org/10.1016/j.neuroscience.2007.10.065
https://doi.org/10.1016/j.neuroscience.2007.10.065
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 3, Pp 249-257 (2007)
The paroxysmal dyskinesias are a group of neurological disorders described by intermittent attacks of involuntary abnormal movements superimposed on a relatively normal baseline. The neuroanatomical substrates for these attacks are not fully understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d6254fa020c5c5b5e72158e64d2682
http://www.sciencedirect.com/science/article/pii/S0969996107001052
http://www.sciencedirect.com/science/article/pii/S0969996107001052
Autor:
Alokes Majumdar, Irène Ceballos-Picot, Mairead Kelly, Kiyoshi Egami, Thomas L. Shirley, Hyder A. Jinnah, J. Chris Lewers, Michael M. Seidman
Publikováno v:
Journal of Neurochemistry. 101:841-853
Mutations in the gene encoding the purine salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HPRT) cause Lesch-Nyhan disease, a neurodevelopmental disorder characterized by cognitive, neurological, and behavioral abnormalities. Despite d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79cf6ba8a851b8213414579eed688421
https://doi.org/10.1111/j.1471-4159.2007.04472.x
https://doi.org/10.1111/j.1471-4159.2007.04472.x
Autor:
Kiyoshi Egami, Hyder A. Jinnah, Amber M. Muehlmann, Bonita L. Blake, George R. Breese, Darragh P. Devine
Publikováno v:
Developmental Neuroscience. 29:241-250
Self-injurious behavior is a common problem in many developmental disorders. The neurobiology of this behavior is not well understood, but the differing behavioral manifestations and associations with different disorders suggest that the underlying b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b44bf781fc69eef537d22d1d218721
https://doi.org/10.1159/000096414
https://doi.org/10.1159/000096414
Publikováno v:
Journal of Inherited Metabolic Disease. 27:165-178
Summary: Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is an enzyme that catalyses the conversion of hypoxanthine and guanine into their respective nucleotides. Inherited deficiency of the enzyme is associated with a loss of striatal dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04b91c8171edc104fce22f7863db01d
https://doi.org/10.1023/b:boli.0000028728.93113.4d
https://doi.org/10.1023/b:boli.0000028728.93113.4d