Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kiyosei Iio"'
Autor:
Yoshiji Hantani, Kiyosei Iio, Rie Hantani, Kayo Umetani, Toshihiro Sato, Tracy Young, Katelyn Connell, Sam Kintz, Joshua Salafsky
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1412-1423 (2018)
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://doaj.org/article/8d0437040b1b4dbdb797c18f711baa16
Autor:
Kiyosei Iio, Akiko Okajima, Yoshifumi Takeda, Ken-ichi Kawaguchi, Brendan A. Whelan, Shuji Akai, Yasuyuki Kita
Publikováno v:
ARKIVOC, Vol 2003, Iss 8, Pp 144-162 (2003)
Externí odkaz:
https://doaj.org/article/a835c552c0104f32be132759ad7ccf1c
Autor:
Tracy A. Young, Toshihiro Sato, Sam Kintz, Kayo Umetani, Kiyosei Iio, Rie Hantani, Joshua Salafsky, Yoshiji Hantani, Katelyn Connell
Publikováno v:
FEBS Open Bio
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635a31bde6e39756a249e1ddbc85cf7
https://doi.org/10.1002/2211-5463.12489
https://doi.org/10.1002/2211-5463.12489
Autor:
Toshiki Urashima, Kiyosei Iio, Fuminori Tokunaga, Yuji Hori, Daisuke Oikawa, Kumiko Ayukawa, Ken Katsuya, Shingo Obika
Publikováno v:
Biochemical and biophysical research communications. 509(3)
Nuclear factor-κB (NF-κB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly complex (LUBAC), composed of the HOIL-1L, HOIP, and SHARPIN su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c5110bee2cf9bd7322af2525bf0cc
https://pubmed.ncbi.nlm.nih.gov/30611571
https://pubmed.ncbi.nlm.nih.gov/30611571
Autor:
Masahiro Suzuki, Akio Kobayashi, Mitsuru Takahashi, Steven M. Rubenstein, Takuya Matsui, Bei Shan, Kazuyuki Sugimoto, Marie-Louise Smith, Xiaolin Hao, Kexue Li, Yukihito Ishii, Masahiro Tanaka, Jian Ken Zhang, Frank Kayser, Mutsuyoshi Matsushita, Takashi Inaba, Rebekah Choi, Shoichi Sagawa, Nobuya Ogawa, Daisuke Tomimoto, Hidekazu Ozeki, Marc Labelle, Guosen Ye, Atsuhito Yoshida, Chihiro Okuma, Kiyosei Iio, Simon Jackson, Shichang Miao, Brian M. Fox, Noboru Furakawa, Dustin McMinn, Ji Ma
Publikováno v:
Journal of Medicinal Chemistry. 57:3464-3483
The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd66a9d1c69543966b744517a5a81420
https://doi.org/10.1021/jm500135c
https://doi.org/10.1021/jm500135c
Autor:
Masahiro Tanaka, Frank Kayser, Takashi Inaba, Atsuhito Yoshida, Brian M. Fox, Bei Shan, Kexue Li, Simon Jackson, Rebeka Choi, Kiyosei Iio, Shoichi Sagawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6030-6033
A new structural class of DGAT1 inhibitors was discovered and the structure–activity relationship was explored. The pyrrolotriazine core of the original lead molecule was changed to a pyrrolopyridazine core providing an increase in potency. Further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace04a667783fe50004f5278b1c1b427
https://doi.org/10.1016/j.bmcl.2010.08.066
https://doi.org/10.1016/j.bmcl.2010.08.066
Autor:
Toshiaki Tsujino, Yasuyuki Kita, Hiromichi Fujioka, Nobuhisa Fukuda, Kiyosei Iio, Tadaatsu Naka, Emi Akiyama, Kazuhiro Higuchi, Ken-ichi Kawaguchi, Yoshifumi Takeda, Shuji Akai
Publikováno v:
Chemistry - A European Journal. 11:6286-6297
The asymmetric total synthesis of the potent antitumor antibiotic fredericamycin A ((S)-1) was achieved by the intramolecular [4+2] cycloaddition of the silylene-protected styrene derivative (S)-7 followed by the aromatic Pummerer-type reaction of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8dc33fe3dcd39cce4613e0500e05a66
https://doi.org/10.1002/chem.200500443
https://doi.org/10.1002/chem.200500443
Autor:
Shuji Akai, Ken-ichi Kawaguchi, Brendan A. Whelan, Kiyosei Iio, Yasuyuki Kita, Yoshifumi Takeda, Akiko Okajima
Publikováno v:
ARKIVOC, Vol 2003, Iss 8, Pp 144-162 (2003)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d51b4e910d39184fe66c844bd66d01f
https://doi.org/10.3998/ark.5550190.0004.815
https://doi.org/10.3998/ark.5550190.0004.815
Autor:
Shuji Akai, Yasuyuki Kita, Nobuhisa Fukuda, Kiyosei Iio, Kazuhiro Higuchi, Toshiaki Tsujino, Tadaatsu Naka, Yoshifumi Takeda, Ken-ichi Kawaguchi
Publikováno v:
Organic Letters. 3:4015-4018
[reaction: see text] An intramolecular enantiodivergent synthesis of both enantiomers of the ABCDE-ring analogue 22 of fredericamycin A is reported. Key steps involve an intramolecular [4 + 2] cycloaddition of 17 and an aromatic Pummerer-type reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2922c22cca9171ceab438acf4896d4a6
https://doi.org/10.1021/ol016696y
https://doi.org/10.1021/ol016696y
Autor:
Nobuhisa Fukuda, Ryuichi Okunaka, Kiyosei Iio, Shuji Akai, Yasuyuki Kita, Toshiaki Tsujino, Kazuhiro Higuchi, Hiroshi Ueno, Yoshifumi Takeda, Hiromichi Fujioka, Ken-ichi Kawaguchi
Publikováno v:
Chemistry. 6:3897-3905
A linear approach to the total synthesis of racemic fredericamycin A (1) through the oxidative intramolecular [4 + 2] cycloaddition of a (phenylthio)acetylene-cobalt complex is described, which is applicable for the asymmetric total synthesis of natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3148b9331f611c0d31ba72d8b3ee0e1c
https://doi.org/10.1002/1521-3765(20001103)6:21<3897::aid-chem3897>3.0.co
https://doi.org/10.1002/1521-3765(20001103)6:21<3897::aid-chem3897>3.0.co