Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Kiyonao Sada"'
Autor:
Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106656- (2024)
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. We evaluated the localization of Syk in the brains of patients with
Externí odkaz:
https://doaj.org/article/239a93f919264675ad69ceb404dfc1d2
Autor:
Eisuke Enoki, Kiyonao Sada, Xiujuan Qu, Shinkou Kyo, S.M. Shahjahan Miah, Tomoko Hatani, Akio Tomoda, Hirohei Yamamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 94, Iss 3, Pp 329-333 (2004)
Antigen-induced aggregation of the high affinity IgE receptor (FcεRI) on mast cells induces degranulation to release chemical mediators, leading to acute allergic inflammation. We have demonstrated that the treatment of rat mast cells, RBL-2H3, with
Externí odkaz:
https://doaj.org/article/0366e304e019405987f2ff910deb4da8
Autor:
Kenji Nakashima, Kenji Takeuchi, Kazuyasu Chihara, Tomoko Horiguchi, Xuedong Sun, Lin Deng, Ikuo Shoji, Hak Hotta, Kiyonao Sada
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46634 (2012)
Hepatitis C virus (HCV) infects B lymphocytes and induces mixed cryoglobulinemia and B cell non-Hodgkin's lymphoma. The molecular mechanism for the pathogenesis of HCV infection-mediated B cell disorders remains obscure. To identify the possible role
Externí odkaz:
https://doaj.org/article/2cfa9aa5882e4284b86c6e2b39448a0f
Autor:
Agata Sekrecka, Katarzyna Kluzek, Michal Sekrecki, Mahdi Eskandarian Boroujeni, Sanaz Hasani, Shota Yamauchi, Kiyonao Sada, Joanna Wesoly, Hans Bluyssen
To understand in detail the transcriptional and functional overlap of IFN-I and IFN-II activated responses, we used an integrative RNAseq-ChIPseq approach in Huh7.5 cells and characterized the genome-wide role of pSTAT1, pSTAT2, IRF9 and IRF1 in time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ac0b4863ab7ceda9e490c2e5721c69
https://doi.org/10.21203/rs.3.rs-2564985/v1
https://doi.org/10.21203/rs.3.rs-2564985/v1
Autor:
Takahiro Yamauchi, Hiromichi Iwasaki, Hiroko Shigemi, Kazuyasu Chihara, Kazuhiro Itoh, Kiyonao Sada
Publikováno v:
Translational Research. 227:53-63
Systemic inflammatory response syndrome and sepsis are considered to contribute to hypercytokinemia in both patients with severe infection and immunocompromised condition. Past research has demonstrated that antibiotics and antifungals not only have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580c3a155739efb93c6c37c934cd4b54
https://doi.org/10.1016/j.trsl.2020.07.005
https://doi.org/10.1016/j.trsl.2020.07.005
Autor:
Ikunobu Muramatsu, Junsuke Uwada, Kazuyasu Chihara, Kiyonao Sada, Mao‐Hsien Wang, Takashi Yazawa, Takanobu Taniguchi, Takaharu Ishibashi, Takayoshi Masuoka
Publikováno v:
Journal of neurochemistryREFERENCES. 160(3)
Cholinergic transmission underlies higher brain functions such as cognition and movement. To elucidate the process whereby acetylcholine (ACh) release is maintained and regulated in the central nervous system, uptake of [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44d7bd4de520987de9a5a623a11e353
https://pubmed.ncbi.nlm.nih.gov/34878648
https://pubmed.ncbi.nlm.nih.gov/34878648
Publikováno v:
The Biochemical journal. 479(4)
The adaptor protein c-Abl Src homology 3 domain-binding protein-2 (3BP2) is phosphorylated by spleen tyrosine kinase (Syk), and the phosphorylation of Tyr183 is important in the regulation of immune responses. Recently, we reported that 3BP2 plays im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c49c574de61ad8a50ca29861d05bfa
https://pubmed.ncbi.nlm.nih.gov/35129602
https://pubmed.ncbi.nlm.nih.gov/35129602
Publikováno v:
The Journal of biological chemistry. 298(4)
Previously, we reported that knockdown of Abl protein tyrosine kinase by shRNA or pharmacological inhibition suppresses particle assembly of J6/JFH1 strain-derived hepatitis C virus (HCV) in Huh-7.5 cells. However, the detailed mechanism by which Abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c43794830af740ccd1ad909fccef364
https://pubmed.ncbi.nlm.nih.gov/35257746
https://pubmed.ncbi.nlm.nih.gov/35257746
Autor:
Takashi Yazawa, Kung-Shing Lee, Ikunobu Muramatsu, Matomo Nishio, Junsuke Uwada, Takanobu Taniguchi, Takayoshi Masuoka, Hatsumi Yoshiki, Kiyonao Sada, Takaharu Ishibashi
Publikováno v:
Journal of Neurochemistry. 149:605-623
Regulation of neurotransmitter release in the central nervous system is complex. Here, we investigated regulatory mechanisms for acetylcholine (ACh) release from cholinergic neurons by performing superfusion experiments with rat striatal segments aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe73a4ee3a3b0621c75d3a3603f761e7
https://doi.org/10.1111/jnc.14701
https://doi.org/10.1111/jnc.14701
Autor:
Masamichi Ikawa, Asako Ueno, Norimichi Shirafuji, Osamu Yamamura, Shu-Hui Yen, Nicholas M. Kanaan, Tadanori Hamano, Hirohito Sasaki, Rei Asano, Yasunari Nakamoto, Soichi Enomoto, Kiyonao Sada, Tomohisa Yamaguchi
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1a75be3a9c0f873aca7f0939e038962
https://doi.org/10.1002/alz.042633
https://doi.org/10.1002/alz.042633