Výsledky vyhledávání - "Kiyomi Yamatsu"

Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds

Autor: Kiyomi Yamatsu, Hachiro Sugimoto, Yoshiharu Yamanishi, Youichi Iimura

Publikováno v: Journal of Medicinal Chemistry. 38:4821-4829

Following the discovery of a new series of anti-acetylcholinesterase (anti-AChE) inhibitors such as 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine (1), we reported that its rigid analogue, 1-benzyl-4-(2-isoindolin-2-ylethyl)piperidine (5), had more p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b39ae9fb1d21565a09d4fc1682dc1
https://doi.org/10.1021/jm00024a009

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Effects of repeated doses of compound E for 4 and 9 weeks on the male reproductive organs

Autor: Nobuhiro Niwa, Satoru Hosokawa, Toshiji Igarashi, Yoshio Matsubara, Yasuyuki Okuda, Kiyomi Yamatsu, Takashi Kawaguchi, Fumihiro Okada

Publikováno v: The Journal of Toxicological Sciences. 20:217-227

Results of two toxicity studies of Compound E, which is an anticancer drug, on male reproductive organs and fertility by oral repeated dosing at dose levels of 12.5, 25 and 50 mg/kg/day for 4 and 9 weeks in rats were compared. After repeated dosing,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bffa3af273a79041a323fe1ac8ed566
https://doi.org/10.2131/jts.20.217

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Immunohistochemical study of BrdU and PCNA as useful markers of cell proliferation in regenerative liver and D-galactosamine-treated liver in rats

Autor: Yasumine Shicchi, Masami Kimura, Taneo Fukuta, Toyohiko Aoki, Kiyomi Yamatsu, Kazuaki Ishihara

Publikováno v: Journal of Toxicologic Pathology. 8:73-80

Comparison of immunohistochemical staining of proliferating cell nuclear antigen (PCNA) and bromodeoxyuridine (BrdU) was studied in rat livers. Experiment 1: Rats were subjected to twothirds partial hepatectomy (PH). Three animals were killed at 1, 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87eae9d7d1e4b53a7d66fd8b2e780199
https://doi.org/10.1293/tox.8.73

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Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) in rat liver

Autor: Chie Furihata, Hirohiko Daimon, Kazuaki Ogura, Kiyomi Yamatsu, Taneo Fukuda, Shigeki Sawada, Shoji Asakura

Publikováno v: Mutation Research/Genetic Toxicology. 322:257-264

The effects of dietary restriction on the induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) were studied in the hepatocytes of F344 rats exposed in vivo to dimethylnitrosamine (DMN) or CCl4. The animals were given food

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cff735a32132332bc74b2d40ed1ecf4
https://doi.org/10.1016/0165-1218(94)90101-5

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Mutagenicity and Cytotoxicity of Naphthoquinones for Ames Salmonella Tester Strains

Autor: Atsushi Hakura, Kiyomi Yamatsu, Hisatoshi Mochida, Yoshie Tsutsui

Publikováno v: Chemical Research in Toxicology. 7:559-567

The molecular mechanisms involved in quinone cytotoxicity, especially mutagenicity, are still largely unknown. In order to better understand the molecular aspects of the mechanisms of quinone mutagenicity and cytotoxicity, we examined them by using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a293ad4e9616efc121159c79bd67608
https://doi.org/10.1021/tx00040a012

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Effects of a daily feeding-restriction on the reproductive and development toxicity parameters in female rats

Autor: Takashi Kawaguchi, Yoshio Matsubara, Toshiji Igarashi, Nobuhiro Niwa, Yasuyuki Okuda, Fumihiro Okada, Kiyomi Yamatsu

Publikováno v: The Journal of Toxicological Sciences. 19:181-187

On the assumption of that the oral administration of an acid-unstable test compound into the empty stomach could enhance the systemic exposure to the test compound, the non-pregnant and pregnant rats had free access to the diet only for five hours pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16439cdaa884a8623094295710a0c1e
https://doi.org/10.2131/jts.19.4_181

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-(2-phthalimidoethyl)piperidine and Related Derivatives

Autor: Kiyomi Yamatsu, Hiroyuki Sugumi, Yutaka Tsuchiya, Atsushi Sasaki, Kunizo Higurashi, Yoshiharu Yamanishi, Norio Karibe, Hachiro Sugimoto, Shin Araki, Yoichi Iimura

Publikováno v: ChemInform. 25

Following the discovery of a new series of 1-benzyl-4-[2-(N-benzoyl-N-methylamino)ethyl]piperidine (2) derivatives with a potent anti-acetylcholinesterase (anti-AChE) activity, we extended the structure-activity relationships (SAR) to rigid analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48418bc043e4f7420518d92a56f1677e
https://doi.org/10.1002/chin.199410176

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-((5,6-dimethoxy-1-oxoindan-2-yl)methyl) piperidine Hydrochloride and Related Compounds

Autor: Kiyomi Yamatsu, Hachiro Sugimoto, Yoshiharu Yamanishi, Youichi Iimura

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba51bc6d3a08e53dd80e6e0da4209d8d
https://doi.org/10.1002/chin.199614152

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