Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kiyomi O, Toyooka"'
Autor:
Raheela Ashfaq, Prakash Makarla, John D. Minna, Adi F. Gazdar, John O. Schorge, Kiyomi O. Toyooka, Shinichi Toyooka, M. Hossein Saboorian
Publikováno v:
Clinical Cancer Research. 11:5365-5369
Purpose: Ovarian carcinomas are believed to arise de novo from surface epithelium, but the actual molecular pathogenesis is unknown. The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better
Autor:
Adi F. Gazdar, Stephen Lam, Sabine Zöchbauer-Müller, Kiyomi O. Toyooka, Shinichi Toyooka, Arvind K. Virmani, John D. Minna, Sonja Seidl
Publikováno v:
International Journal of Cancer. 107:612-616
An important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions. In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), C
Autor:
Kenji Sugio, Sabine Zöchbauer-Müller, Shinichi Toyooka, Adi F. Gazdar, John D. Minna, Michael Z. Gilcrease, Huei Lee, Dale McLerran, Kwun M. Fong, Kazunori Tsukuda, Kiyomi O. Toyooka, Chih Yi Chen, Riichiroh Maruyama, Arvind K. Virmani, Ziding Feng, Yasuro Fukuyama, Kenji Shimizu, Nobuyoshi Shimizu, Jack A. Roth
Publikováno v:
International Journal of Cancer. 103:153-160
Aberrant methylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers. There are major smoke exposure, histology, geography and gender-related changes in non-small cell lung cancer (NSCLC).
Autor:
Shinichi Toyooka, Anirban Maitra, Alice L. Smith, John D. Minna, Nancy C. Kiviat, Adi F. Gazdar, Qinghua Feng, Kiyomi O. Toyooka, Raheela Ashfaq
Publikováno v:
The American Journal of Pathology. 161:629-634
Aberrant methylation of the promoter region has emerged as the major mechanism for silencing tumor suppressor genes. However, for some genes, such as E-cadherin (CDH1), methylation and protein expression demonstrate considerable heterogeneity, making
Autor:
John D. Minna, Maurizio Bocchetta, Adi F. Gazdar, Michele Carbone, Kiyomi O. Toyooka, Shinichi Toyooka, Narayan Shivapurkar
Publikováno v:
Oncogene. 21:4340-4344
Mesotheliomas are tumors arising from mesothelial cells and are associated with asbestos exposure and approximately 50% contain simian virus 40 (SV40) DNA sequences. SV40 infection of human mesothelial cells (HM) causes early cellular immortalization
Autor:
Robert J. Hay, Charles F. Timmons, John D. Minna, Domenico Mastrangelo, Adi F. Gazdar, Kiyomi O. Toyooka, Gail E. Tomlinson, Kenichi Harada, Anirban Maitra, Shinichi Toyooka, Riichiroh Maruyama
Publikováno v:
Oncogene. 21:4345-4349
Aberrant promoter methylation of tumor suppressor genes has not been fully investigated in pediatric tumors. Therefore, we examined the methylation status of nine genes (p16(INK4A), MGMT, GSTP1, RASSF1A, APC, DAPK, RARbeta, CDH1 and CDH13) in 175 pri
Autor:
Adi F. Gazdar, T. Fujisawa, Makoto Suzuki, Kazunori Tsukuda, Kiyomi O. Toyooka, Nobuyoshi Shimizu, Yasuro Fukuyama, T. Iizasa, Riichiroh Maruyama, Shinichi Toyooka, Hiroshi Date, Motoi Aoe
Publikováno v:
British Journal of Cancer
The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes
Autor:
Kazunori Tsukuda, Shinichi Toyooka, Toshihiko Iizasa, Yasuro Fukuyama, John D. Minna, Makoto Suzuki, Adi F. Gazdar, Takehiko Fujisawa, Toshihide Tsuda, Riichiroh Maruyama, Kiyomi O. Toyooka, Nobuyoshi Shimizu
Publikováno v:
International journal of cancer. 110(3)
Autor:
Adi F. Gazdar, Jyotsna Reddy, Kuniharu Miyajima, Makoto Suzuki, Gunjan Parikh, Kiyomi O. Toyooka, Shinichi Toyooka, Takao Takahashi, Preet M. Chaudhary, Harvey I. Pass, Narayan Shivapurkar, Hisayuki Shigematsu
Publikováno v:
International journal of cancer. 109(5)
TNF-related apoptosis-inducing ligand (TRAIL) selectively induces programmed cell death (apoptosis) in various cancer cells but not in normal cells. TRAIL is known to bind to 4 different receptors, 2 proapoptotic (DR4 and DR5), and 2 potentially anti
Autor:
Sabine, Zöchbauer-Müller, Stephen, Lam, Shinichi, Toyooka, Arvind K, Virmani, Kiyomi O, Toyooka, Sonja, Seidl, John D, Minna, Adi F, Gazdar
Publikováno v:
International journal of cancer. 107(4)
An important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions. In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), C