Výsledky vyhledávání

First clinical pharmacokinetic dose-escalation study of sagopilone, a novel, fully synthetic epothilone, in Japanese patients with refractory solid tumors

Autor: Toru Mukohara, Kazuhiro Araki, Keiji Kodama, Kiyomi Mera, Hirofumi Mukai, Yuichi Ando, Masaru Narabayashi, Yasutsuna Sasaki, Koichi Kitagawa, Hironobu Minami

Publikováno v: Investigational New Drugs. 30:2327-2333

Purpose Sagopilone has recently been identified and preferentially used for the treatment of taxane-resistant cancer. The purpose of this dose-escalation study was to investigate the safety, tolerability, and pharmacokinetics (PK) of sagopilone in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9cbd5b49f1a5de9073397944b4d7ca
https://doi.org/10.1007/s10637-011-9773-7

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A Retrospective Study of Definitive Chemoradiotherapy for Elderly Patients With Esophageal Cancer

Autor: Satoshi Takeuchi, Makoto Tahara, Keiko Minashi, Keiji Nihei, Atsushi Ohtsu, Tomonori Yano, Manabu Muto, Toshihiko Doi, Takashi Kojima, Kiyomi Mera

Publikováno v: American Journal of Clinical Oncology. 30:607-611

The efficacy and safety of definitive chemoradiotherapy (CRT) for elderly patients with esophageal cancer have not been fully elucidated yet. We conducted a retrospective comparison of the outcomes of CRT between elderly and nonelderly patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ec60873f4f9ce79bd62c44602077f0
https://doi.org/10.1097/coc.0b013e3180ca7c84

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Phase I/II Study of Oxaliplatin with Weekly Bolus Fluorouracil and High-Dose Leucovorin (ROX) As First-Line Therapy for Patients with Colorectal Cancer

Autor: Kiyomi Mera, Yoshinori Miyata, Yasuhiro Shimada, Kuniaki Shirao, Yasuhide Yamada, Atsushi Ohtsu, Tomonori Yano, Tetsuya Hamaguchi, Yusuke Tanigawara, Kei Muro, Narikazu Boku, Toshihiko Doi, Manabu Muto

Publikováno v: Japanese Journal of Clinical Oncology. 36:218-223

Infusional fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin is one of the current standard regimens for the treatment of patients with metastatic colorectal cancer. Weekly bolus 5-FU with high-dose LV (Roswell Park Memorial Institute Regimen:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10054c2b44ffdf765a7c0c0ef75da187
https://doi.org/10.1093/jjco/hyl020

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Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma

Autor: Atsushi Ochiai, Atsushi Ohtsu, Yukio Kobayashi, Ichiro Oda, Kensei Tobinai, Tadashi Yoshino, Satoshi Ishikura, Yoshihiro Matsuno, Shigeo Nakamura, Junji Suzumiya, Kiyomi Mera, Yasuhiko Kitadai, Takio Yokoi

Publikováno v: Cancer Science. 97:163-166

Primary gastric diffuse large B-cell lymphomas are generally well controlled by non-surgical treatment with combination chemotherapy followed by radiotherapy. We have previously reported that over 90% of patients achieved complete response (CR) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf58f43a23fd5911d109ce453a5367f
https://doi.org/10.1111/j.1349-7006.2006.00155.x

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Distribution and prevalence of colorectal hyperplastic polyps using magnifying pan-mucosal chromoendoscopy and its relationship with synchronous colorectal cancer: Prospective study

Autor: Junko Iwasaki, Shigeaki Yoshida, Takahiro Fujii, Atsushi Ochiai, Kuang-I Fu, Tomonori Yano, Yasushi Sano, Kiyomi Mera, Takayuki Yoshino, Shigeharu Kato

Publikováno v: Journal of Gastroenterology and Hepatology. 20:1572-1577

Background and Aim: Patients with multiple (hyperplastic polyposis) or large hyperplastic polyps (HPs) predominantly in the right-sided colon, have been reported to have an increased risk of colorectal cancer (CRC). This prospective study was conduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e940bd6bf6ba209684efb2b040b483
https://doi.org/10.1111/j.1440-1746.2005.03970.x

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A phase I/II study of nedaplatin and 5-fluorouracil with concurrent radiotherapy in patients with T4 esophageal cancer: Japan Clinical Oncology Group trial (JCOG 9908)

Autor: Narikazu Boku, Yoshikazu Kagami, Keiji Nihei, Shigeaki Yoshida, Yoshinori Ito, Atsushi Ohtsu, Satoshi Ishikura, Kiyomi Mera, Kuniaki Shirao, Kei Muro

Publikováno v: Esophagus. 2:133-137

Background Nedaplatin is an analogue of cisplatin with less nonhematologic toxicity. The combination of nedaplatin and 5-fluorouracil showed a promising response rate in a previous phase II study for metastatic esophageal cancer. The purpose of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f3b90b5a16492a2ba094734e4960bcd
https://doi.org/10.1007/s10388-005-0055-3

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Japanese multicenter phase II study of CHOP followed by radiotherapy in stage I-II1, diffuse large B-cell lymphoma of the stomach

Autor: Satoshi Ishikura, Yoshio Tamaki, Tadashi Yoshino, Seiichiro Yamamoto, Kiyomi Mera, Shigeo Nakamura, Yoshikazu Kagami, Kuniaki Itoh, Masafumi Taniwaki, Junji Suzumiya, Atsushi Ohtsu, Toshiyuki Takagi, Ichiro Oda, Kensei Tobinai

Publikováno v: Cancer Science. 96:349-352

CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) followed by radiotherapy is regarded as standard care for localized aggressive lymphoma; however, prospective confirmation of its applicability to localized primary gastric lymphoma is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d6a22b604933036e684371083e907ae
https://doi.org/10.1111/j.1349-7006.2005.00051.x

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Pilot Study of Transcatheter Arterial Chemoembolization with Degradable Starch Microspheres in Patients With Hepatocellular Carcinoma

Autor: Shigeru Mikami, Kiyomi Mera, Junji Furuse, Hiroshi Ishii, Masahiro Yoshino, Hideki Sakai, Hiroaki Onaya, Haruhiko Nose, Yasushi Maru, Mitsuo Satake

Publikováno v: American Journal of Clinical Oncology. 26:159-164

We prospectively evaluated the efficacy and safety of transcatheter arterial chemoembolization (TACE) with microembolization material, degradable starch microspheres (DSMs), and epirubicin, for treatment of multifocal hepatocellular carcinoma (HCC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2ffc6d44297070da2f75efce49866e
https://doi.org/10.1097/00000421-200304000-00012

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Multicenter Phase II Study of FOLFOX6 for Previously Untreated Unresectable Metastatic Colorectal Cancer

Autor: Satoshi Ikeda, Tatsuhiro Arai, Hisateru Yasui, Kenichi Sugihara, Yutaka Ogata, Kenji Katsumata, Kiyomi Mera, Satoru Iwasa, Yoshitaka Inaba, Takeshi Kato, Tomoyuki Kato, Yasuhiro Shimada, Tetsuya Hamaguchi, Makoto Akaike

Publikováno v: Journal of Integrative Oncology.

Background: This phase II study investigated the safety and efficacy of an oxaliplatin, fluorouracil, and lleucovorin regimen (FOLFOX6) in Japanese patients with previously untreated, unresectable metastatic colorectal cancer because oxaliplatin of F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dafaad061119fc36a93ab1746f4dea7
https://doi.org/10.4172/2329-6771.1000120

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Sequential methotrexate and 5-fluorouracil therapy for gastric cancer patients with peritoneal dissemination: a retrospective study

Autor: Shuichi Hironaka, Hisao Tajiri, Narikazu Boku, Shigeaki Yoshida, Motoki Yoshida, Atsushi Ohtsu, Manabu Muto, Fumio Nagashima, Kiyomi Mera, Makoto Tahara, Yasushi Sano

Publikováno v: Gastric Cancer. 4:212-218

Background. Most gastric cancer patients with peritoneal dissemination have been excluded from clinical studies because they usually have no measurable lesions. They also have a high risk of toxicity because of complications such as intestinal obstru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff7d83f706e2a2dd83b0c5d5e1ee470
https://doi.org/10.1007/s10120-001-8012-x

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