Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kiyoko Izawa"'
Autor:
Yusuke Inoue, Fugeng Sheng, Shigeru Kiryu, Makoto Watanabe, Harnprasopwat Ratanakanit, Kiyoko Izawa, Arinobu Tojo, Kuni Ohtomo
Publikováno v:
Molecular Imaging, Vol 10 (2011)
Gaussia luciferase (Gluc) is a secreted reporter, and its expression in living animals can be assessed by in vivo bioluminescence imaging (BLI) or blood assays. We characterized Gluc as an in vivo reporter in comparison with firefly luciferase (Fluc)
Externí odkaz:
https://doaj.org/article/32daf40af16f4fb3b309fc98d98cdeac
Publikováno v:
Molecular Imaging, Vol 7 (2008)
We investigated the effect of diet on abdominal autofluorescence detected by in vivo fluorescence imaging (FLI) of living mice. Groups of mice were fed a regular, alfalfa-free, or purified diet, and whole-body FLI was performed without the administra
Externí odkaz:
https://doaj.org/article/3dbe21c9d31f4c2c9c93dfcfdf243ca4
Publikováno v:
Molecular Imaging, Vol 5 (2006)
The identification of organs bearing luciferase activity by in vivo bioluminescence imaging (BLI) is often difficult, and ex vivo imaging of excised organs plays a complementary role. This study investigated the importance of exposure to the atmosphe
Externí odkaz:
https://doaj.org/article/1e0453d345a44ac3a609afdd1f6787c7
Autor:
Masahiro Ikeda, Muneyoshi Futami, Bidisha Chanda, Masayuki Kobayashi, Kiyoko Izawa, Arinobu Tojo
Publikováno v:
Biochemical and Biophysical Research Communications. 622:177-183
Severe congenital neutropenia (SCN) is characterized by severe neutropenia and recurrent critical infections. X-linked neutropenia (XLN) is caused by a gain-of-function mutation in the Wiskott-Aldrich syndrome gene (WAS), the product of which (WASp)
Autor:
Atsushi Iwama, Motohiko Oshima, Koutaro Yokote, Satoshi Kaito, Daisuke Shinoda, William Joseph Lennox, Yurie Nagai, Emiko Sakaida, Wakako Kuribayashi, Josephine Sheedy, Marla Weetall, Shuhei Koide, Naoya Mimura, Yaeko Nakajima-Takagi, Kiyoko Izawa, Masayuki Yamashita, Atsushi Miyawaki, Satoshi Yamazaki, Kensuke Kayamori, Hans Jiro Becker, Kaoru Tohyama, Ryoji Ito, Satoshi Iwano, Cheng Zhong
Publikováno v:
Blood Adv
Dihydroorotate dehydrogenase (DHODH) catalyzes a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH inhibition has recently been recognized as a potential new approach for treating acute myeloid leukemia (AML) by inducing differenti
Autor:
Kiyoko Izawa, Muneyoshi Futami, Masahiro Ikeda, Arinobu Tojo, Bidisha Chanda, Masayuki Kobayashi
Publikováno v:
Blood. 136:39-40
Severe congenital neutropenia (SCN) is characterized by severe neutropenia and recurrent episodes of critical infections. X-linked neutropenia (XLN) is a very rare type of SCN caused by a gain-of-function mutation in the Wiscott-Aldrich syndrome gene
Autor:
Arinobu Tojo, Tomoya Kakegawa, Hans Jiro Becker, Kiyoko Izawa, Momoko Sakaguchi, Joydeep Bhadury, Satoshi Yamazaki
Publikováno v:
Experimental hematology. 89
Hematopoietic stem cells (HSCs) are multipotent cells that form the entire blood system and have the potential to cure several pathogenic conditions directly or indirectly arising from defects within the HSC compartment. Pluripotent stem cells (PSCs)
Autor:
Kenzaburo Tani, Kiyoko Izawa, Yasushi Soda, Shigetaka Asano, Seiichiro Kobayashi, Minghan Chen, Arinobu Tojo, Kazuo Maruyama
Publikováno v:
International Journal of Pharmaceutics. 454:478-485
Here we have developed a versatile liposome-mediated drug delivery system (DDS) allowing a strong bridge between the streptavidin-tagged liposome (SAL) and biotin (Bi)-tagged biomaterials which has strong affinity to surface proteins expressed in res
Autor:
Kenzaburo Tani, Yuansong Bai, Seiichiro Kobayashi, Yasushi Soda, Yamin Tian, Manabu Ozawa, Naoki Oyaizu, Yan Dong, Erika Sasaki, Arinobu Tojo, Chieko Kai, Kiyoko Izawa, Toshio Itoh, Yoshiro Maru, Takafumi Hiramoto, Kaoru Uchimaru, Satoshi Takahashi
Publikováno v:
Open Journal of Blood Diseases. :1-10
Patients with Philadelphia chromosome (p190 BCR-ABL fusion gene)-positive acute lymphoblastic leukemia have a poor prognosis despite intensive therapeutic intervention.In this study, we attempted to develop a leukemia nonhuman primate model that mimi
Autor:
Seiichiro Kobayashi, Takaomi Ishida, Arinobu Tojo, Hui-Jen Tsai, Kazuo Umezawa, Sheng-Fung Lin, Kiyoko Izawa, Toshiki Watanabe
Publikováno v:
Cancer Science. 102:2014-2021
To gain an insight into the microenvironmental regulation of nuclear factor (NF)-κB activity in the progression of leukemia, we established a bioluminescent imaging model of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) cell