Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kiyoko Fujita"'
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent threat to public health requiring the development of novel therapies. TP0586532 is a novel non-hydroxamate LpxC inhibitor that inhibits the synthesis of lipopolysaccharides, which a
Externí odkaz:
https://doaj.org/article/2ed7d709838b4a44a9ffcf92f49f6486
Publikováno v:
The Journal of Antibiotics
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is an essential enzyme in the biosynthesis of Lipid A, an active component of lipopolysaccharide (LPS), from UDP-3-O-acyl-N-acetylglicosamine. LPS is a major component of the cell surface of Gram-ne
Autor:
Iichiro Takata, Hirotoshi Okumura, Hajime Takashima, Ippei Yoshida, Kiyoko Fujita, Katsumasa Otake, Hiroyuki Sugiyama
Publikováno v:
The Journal of Antibiotics. 75:98-107
The emergence of multi-drug resistant pathogenic bacteria, especially Gram-negative bacteria, is a worldwide health problem. New antibiotics directed at previously unexplored targets are urgently needed to overcome resistance to existing antibiotic c
Autor:
Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Yusuke Honma, Hirotoshi Okumura, Katsumasa Otake, Hajime Takashima, Hiroyuki Sugiyama
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 28(5)
TP0586532 is a novel non-hydroxamate UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitor. Pharmacokinetic/pharmacodynamic (PK/PD) indices and magnitude of index that correlated with the efficacy of TP0586532 were determined and used to esti
Autor:
Iichiro Takata, Aiko Masuko, Hiroyuki Sugiyama, Fumihito Ushiyama, Hirotoshi Okumura, Hideaki Amada, Kiyoko Fujita
Publikováno v:
Antimicrob Agents Chemother
Gonorrhea is a common, sexually transmitted disease caused by Neisseria gonorrhoeae. Multidrug-resistant N. gonorrhoeae is an urgent threat, and the development of a new antimicrobial agent that functions via a new mechanism is strongly desired. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3cbf3df7c907d819a3c3bc22ce9e09
https://europepmc.org/articles/PMC8097434/
https://europepmc.org/articles/PMC8097434/
Autor:
Yuya Ogata, Harumi Kanazawa, Macias Alba, Norikazu Ohtake, Allan E. Surgenor, Iichiro Takata, Hajime Takashima, Walmsley David, Kiyoko Fujita, Hayley Angove, Kunihiko Iwamoto, Masashi Mima, Hiroyuki Sugiyama, Fumihito Ushiyama, Junya Yamagishi, Yousuke Yamada, Alan P. Robertson, Kosuke Hitaka, Koichiro Nakano, Hayato Watanabe, Atsushi Okada, Yohei Matsuda, Roderick E. Hubbard, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Risa Kurimoto-Tsuruta, Lisa Baker, Akihiro Tanaka, R. Harris
Publikováno v:
Journal of medicinal chemistry. 63(23)
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-negative bacteria. The most advanced, disclosed Lp
Autor:
Yuya Ogata, Nozomi Tanaka-Yamamoto, Naoki Sasamoto, Iichiro Takata, Katsumasa Otake, Hajime Takashima, Yohei Matsuda, Haruhiro Yamashita, Mayumi Endo, Kiyoko Fujita, Kaori Ueki, Masashi Mima, Satoshi Tsuji, Hirotoshi Okumura, Hiroyuki Sugiyama, Fumihito Ushiyama, Risa Kurimoto-Tsuruta
Publikováno v:
Bioorganicmedicinal chemistry. 30
Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly de
Autor:
Hiroyuki Sugiyama, Hiroyuki Suematsu, Kiyoko Fujita, Iichiro Takata, Yuka Yamagishi, Hiroshige Mikamo
Publikováno v:
Anaerobe. 57
Aspiration pneumonia is an infectious disease of the lungs caused by inhalation of saliva or foods, associated with swallowing dysfunction. Therefore, the major causative organisms are oral or gastric bacteria. In this study, we evaluated the antimic
Autor:
Kiyoko Fujita, Seiichiro Fujisaki, Shingo Toji, Katsuyuki Tamai, Takashi Kubota, Takahide Hayano, Shirou Ibe, Yuko Ohta, Noriko Shimazaki, Osamu Koiwai
Publikováno v:
Genes to Cells. 8:559-571
Background: Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase that enhances the Ig and TcR gene diversity in the N region at the junctions of variable (V), diversity (D) and joining (J) segments in B- and T-cells. TdT synthesizes the N r
Autor:
Hiroko Yamamoto, Noriko Shimazaki, Shingo Toji, Sachiko Kuroda, Shirou Ibe, Reo Kaneko, Katsuyuki Tamai, Izumi Takebe, Kiyoko Fujita, Akiko Tanabe, Tsuguri Toyomoto, Tamami Kobayashi, Osamu Koiwai
Publikováno v:
Genes to Cells. 6:815-824
Background The repertoires of Ig and TcR are generated by a combinatorial rearrangement of variable (V), diversity (D), and joining (J) segments (V(D)J recombination) in B- and T-cells. Terminal deoxynucleotidyltransferase (TdT) adds extra nucleotide