Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kiyoka Saito"'
Autor:
Kiyoka Saito, Mark van der Garde, Terumasa Umemoto, Natsumi Miharada, Julia Sjöberg, Valgardur Sigurdsson, Haruki Shirozu, Shunsuke Kamei, Visnja Radulovic, Mitsuyoshi Suzuki, Satoshi Nakano, Stefan Lang, Jenny Hansson, Martin L. Olsson, Takashi Minami, Gunnar Gouras, Johan Flygare, Kenichi Miharada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Hematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their er
Externí odkaz:
https://doaj.org/article/c454b7e49a8c4be7938a4dfcf040f95f
Autor:
Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama, Tetsuya Taga
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-17 (2023)
Abstract Background During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aorta’s intra-aortic h
Externí odkaz:
https://doaj.org/article/85816b709bcc4d1793f1959a6070ad8f
Autor:
Shuhei Koide, Valgardur Sigurdsson, Visnja Radulovic, Kiyoka Saito, Zhiqian Zheng, Stefan Lang, Shamit Soneji, Atsushi Iwama, Kenichi Miharada
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103603- (2022)
Summary: Isolation of long-term hematopoietic stem cell (HSC) is possible by utilizing flow cytometry with multiple cell surface markers. However, those cell surface phenotypes do not represent functional HSCs after in vitro culture. Here we show tha
Externí odkaz:
https://doaj.org/article/4ed8a9b81e1147e4ae4d1b2ef49c5c25
Autor:
Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama, Tetsuya Taga
BackgroundDuring mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aorta’s intra-aortic hematopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f052479bce1f2e23ea9e198c841ec2a0
https://doi.org/10.1101/2022.11.01.513960
https://doi.org/10.1101/2022.11.01.513960
Autor:
Tetsuya Taga, Ayumi Itabashi, Atsushi Iwama, Melig Gerel, Kiyoka Saito, Satomi Takahashi, Kaho Harada, Takaho A. Endo, Mitsujiro Osawa, Ikuo Nobuhisa
Publikováno v:
Differentiation. 115:53-61
Hematopoietic stem cell-containing intra-aortic hematopoietic cell clusters (IAHCs) emerge in the dorsal aorta of the aorta-gonad-mesonephros (AGM) region during midgestation mouse embryos. We previously showed that transduction of Sox17 in CD45lowc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422e50f2192f3bcf62c842a493f8de13
https://doi.org/10.1016/j.diff.2020.08.001
https://doi.org/10.1016/j.diff.2020.08.001
Autor:
Kiyoka Saito, Mark van der Garde, Terumasa Umemoto, Satoshi Nakano, Natsumi Miharada, Alban Johansson, Visnja Radulovic, Valgardur Sigurdsson, Stefan Lang, Bodil Israelsson, Gunnar Gouras, Johan Flygare, Kenichi Miharada
Publikováno v:
Experimental Hematology. 111:S133-S134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90284096db58dd5477cb1bb6075078ce
https://doi.org/10.1016/j.exphem.2022.07.234
https://doi.org/10.1016/j.exphem.2022.07.234
Autor:
Shuhei Koide, Valgardur Sigurdsson, Visnja Radulovic, Kiyoka Saito, Zhiqian Zheng, Stefan Lang, Shamit Soneji, Atsushi Iwama, Kenichi Miharada
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103603-(2022)
iScience
iScience
Summary Isolation of long-term hematopoietic stem cell (HSC) is possible by utilizing flow cytometry with multiple cell surface markers. However, those cell surface phenotypes do not represent functional HSCs after in vitro culture. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5cf9360b6cc02937b3fbcc0d2e3df0
https://pubmed.ncbi.nlm.nih.gov/35005548
https://pubmed.ncbi.nlm.nih.gov/35005548
Publikováno v:
Cytokine. 95:35-42
In the midgestation mouse embryo, hematopoietic cell clusters containing hematopoietic stem/progenitor cells arise in the aorta-gonad-mesonephros (AGM) region. We have previously reported that forced expression of the Sox17 transcription factor in CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4070a5910e92ab5c9655f75905f9a4ed
https://doi.org/10.1016/j.cyto.2017.02.012
https://doi.org/10.1016/j.cyto.2017.02.012
Autor:
Kaho Harada, Satomi Takahashi, Tetsuya Taga, Ikuo Nobuhisa, Heiko Lickert, Masami Kanai-Azuma, Maha Anani, Kiyoka Saito, Yoshiakira Kanai
Publikováno v:
Exp. Cell Res. 365, 145-155 (2018)
The aorta-gonad-mesonephros region, from which definitive hematopoiesis first arises in midgestation mouse embryos, has intra-aortic hematopoietic clusters (IAHCs) containing hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc66a04993966cbafec33f4e60559a3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55462
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55462
Autor:
Atsushi Iwama, Tetsuya Taga, Kiyoka Saito, Ikuo Nobuhisa, Maha Anani, Mitsujiro Osawa, Kaho Harada
Publikováno v:
Development, Growth & Differentiation. 56:469-479
Sry related high mobility group box 17 (Sox17), which is a marker of endodermal cells and a transcriptional regulator, has a critical role in the maintenance of fetal and neonatal hematopoietic stem cells (HSC). Sox17 has been identified as a key reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5578b138527cd89f1baa75800426731
https://doi.org/10.1111/dgd.12147
https://doi.org/10.1111/dgd.12147