Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Kiyohisa Mizumoto"'
Autor:
Naoki Takizawa, Toshinobu Fujiwara, Manabu Yamasaki, Ayako Saito, Akira Fukao, Akio Nomoto, Kiyohisa Mizumoto
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78000 (2013)
mRNA capping is the first cotranscriptional modification of mRNA in the nucleus. In Saccharomyces cerevisiae, the first two steps of mRNA capping are catalyzed by the RNA triphosphatase Cet1p and the RNA guanylyltransferase Ceg1p. Cet1p and Ceg1p int
Externí odkaz:
https://doaj.org/article/d0d35264e6ad48439fdafa63392bd887
Autor:
Ryuichi Sawa, Kiyoko Iijima, Taira Kato, Akio Nomoto, Masayuki Igarashi, Masaki Hatano, Chisato Nosaka, Maya Umekita, Kiyohisa Mizumoto, Naoki Takizawa, Manabu Yamasaki, Tomoyuki Kimura
Publikováno v:
The Journal of Antibiotics. 72:125-133
Influenza virus RNA polymerase has cap-dependent endonuclease activity that produces capped RNA fragments for priming viral mRNA synthesis. This enzymatic activity is essential for viral propagation, but it is not present in any host cellular enzyme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51941c2a805cfee0bb90648b4a3254
https://doi.org/10.1038/s41429-018-0134-z
https://doi.org/10.1038/s41429-018-0134-z
Autor:
Masaki Hatano, Maya Umekita, Akio Nomoto, Kiyohisa Mizumoto, Manabu Yamasaki, Masayuki Igarashi, Ryuichi Sawa, Toshinobu Fujiwara, Chigusa Hayashi
Publikováno v:
The Journal of antibiotics. 70(5)
Yeast capping enzymes differ greatly from those of mammalian, both structurally and mechanistically. Yeast-type capping enzyme repressors are therefore candidate antifungal drugs. The 5′-guanine-N7 cap structure of mRNAs are an essential feature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080f1ad213af6ca4620d92b82bd44ab6
https://pubmed.ncbi.nlm.nih.gov/28074052
https://pubmed.ncbi.nlm.nih.gov/28074052
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819:78-83
Influenza virus RNA polymerase (RdRp) PB2 is the cap-1 binding subunit and determines host range and pathogenicity. The mutant human influenza virus RdRp containing PB2 D701N and D701N/S714R demonstrated enhanced replicon activity in mammalian cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5ed2f3ed51b609438560cf24b963e9
https://doi.org/10.1016/j.bbagrm.2011.11.006
https://doi.org/10.1016/j.bbagrm.2011.11.006
Publikováno v:
Journal of Virology. 85:7504-7512
The cap-dependent endonuclease activity of the influenza virus RNA-dependent RNA polymerase cleaves host mRNAs to produce capped RNA fragments for primers to initiate viral mRNA synthesis. The influenza A virus (FluA) cap-dependent endonuclease prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbc991ceab258279533208f5126f46a
https://doi.org/10.1128/jvi.02375-10
https://doi.org/10.1128/jvi.02375-10
Sendai Virus RNA-dependent RNA Polymerase L Protein Catalyzes Cap Methylation of Virus-specific mRNA
Publikováno v:
Journal of Biological Chemistry. 280:4429-4435
The Sendai virus (SeV) RNA-dependent RNA polymerase complex, which consists of L and P proteins, participates in the synthesis of viral mRNAs that possess a methylated cap structure. To identify the SeV protein(s) involved in mRNA cap methylation, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b5d04fa8263b3f20a422ff66bd855
https://doi.org/10.1074/jbc.m411167200
https://doi.org/10.1074/jbc.m411167200
Autor:
Kohji Moriishi, Shinichiro Sakamoto, Takuya Iwasaki, Takashi Shimoike, Takeya Tsutsumi, Tetsuro Suzuki, Tatsuo Miyamura, Akiko Rikimaru, Yoshiharu Matsuura, Keiko Tanaka, Kiyohisa Mizumoto, Ryosuke Suzuki
Publikováno v:
Journal of Virology. 79:1271-1281
Hepatitis C virus (HCV) core protein is a putative nucleocapsid protein with a number of regulatory functions. In tissue culture cells, HCV core protein is mainly located at the endoplasmic reticulum as well as mitochondria and lipid droplets within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edc1f250c67173f127f05e197081293
https://doi.org/10.1128/jvi.79.2.1271-1281.2005
https://doi.org/10.1128/jvi.79.2.1271-1281.2005
Autor:
Megumi Kurita, Kiyohisa Mizumoto, Masaaki Matsuoka, Sadakazu Aiso, Hiroaki Suzuki, Masatsugu Moriyama, Ikuo Nishimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 326:242-248
The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2562db4f4b85ce13b04c76df4faa449
https://doi.org/10.1016/j.bbrc.2004.11.016
https://doi.org/10.1016/j.bbrc.2004.11.016
Autor:
Kiyohisa Mizumoto, Etsuro Ogata, Hiroaki Suzuki, Masaaki Matsuoka, Megumi Kurita, Ikuo Nishimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 312:1273-1277
Combined disruption of the ARF gene and the p53 gene causes mouse predisposition to tumors of a wider variety and at a higher frequency than disruption of the p53 gene, indicating that the ARF gene has p53-independent anti-tumor function in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce70f5e52df980c201626ca9c5ed58b
https://doi.org/10.1016/j.bbrc.2003.11.071
https://doi.org/10.1016/j.bbrc.2003.11.071
Publikováno v:
Biochemical and Biophysical Research Communications. 311:283-293
Cellular tubulin has been shown to activate in vitro transcription with Sendai virus (SeV) particles. In this study, the molecular basis for the transcriptional activation by tubulin was investigated. We showed that tubulin dissociates viral matrix (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c25781d7ede4111e5e0d8e24f51ddc
https://doi.org/10.1016/j.bbrc.2003.09.205
https://doi.org/10.1016/j.bbrc.2003.09.205