Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kiyohiro Takahasi"'
Publikováno v:
F1000Research, Vol 5 (2016)
Recent accumulation of sequence and structural data, in conjunction with systematical classification into a set of families, has significantly advanced our understanding of diverse and specific protein functions. Analysis and interpretation of protei
Externí odkaz:
https://doaj.org/article/cf737700a1414d2a9985ee7f945a9079
Publikováno v:
F1000Research, Vol 5 (2016)
Recent accumulation of sequence and structural data, in conjunction with systematical classification into a set of families, has significantly advanced our understanding of diverse and specific protein functions. Analysis and interpretation of protei
Externí odkaz:
https://doaj.org/article/a6849f192bc947fdb19fb482b0c4f252
Autor:
Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, Emi Hirano, Seiji P Yamamoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004417 (2014)
RIG-I-like receptor (RLR) plays a pivotal role in the detection of invading pathogens to initiate type I interferon (IFN) gene transcription. Since aberrant IFN production is harmful, RLR signaling is strictly regulated. However, the regulatory mecha
Externí odkaz:
https://doaj.org/article/6d58c480e109408b8f3a596e4b84af2b
Autor:
Ji-Seung Yoo, Kiyohiro Takahasi, Chen Seng Ng, Ryota Ouda, Koji Onomoto, Mitsutoshi Yoneyama, Janice Ching Lai, Simon Lattmann, Yoshikuni Nagamine, Tadashi Matsui, Kuniyoshi Iwabuchi, Hiroki Kato, Takashi Fujita
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004012 (2014)
RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling b
Externí odkaz:
https://doaj.org/article/4ea6becc61ad46e98744b4fd2a946be6
Autor:
Shiori Takamatsu, Kazuhide Onoguchi, Koji Onomoto, Ryo Narita, Kiyohiro Takahasi, Fumiyoshi Ishidate, Takahiro K Fujiwara, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53578 (2013)
The innate immune system recognizes viral nucleic acids and stimulates cellular antiviral responses. Intracellular detection of viral RNA is mediated by the Retinoic acid inducible gene (RIG)-I Like Receptor (RLR), leading to production of type I int
Externí odkaz:
https://doaj.org/article/64fceae48bba4d2698d93f9505f2a71b
Autor:
Hiroki Kato, Masataka Horiuchi, Takashi Fujita, Mitsutoshi Yoneyama, Koji Onomoto, Kiyohiro Takahasi
Publikováno v:
Biochemical and Biophysical Research Communications. 517:662-669
Upon viral infection, retinoic acid-inducible gene-I (RIG-I)-like receptors detect viral foreign RNAs and transmit anti-viral signals via direct interaction with the downstream mitochondrial adaptor molecule, interferon (IFN)-β promoter stimulator-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f61fd5b782fb4decf89e062cb899f2c
https://doi.org/10.1016/j.bbrc.2019.07.099
https://doi.org/10.1016/j.bbrc.2019.07.099
Autor:
Hiroyuki Itoh, Hiroyuki Kumeta, Michio Yazawa, Yoshihiro Kobashigawa, Kenji Ogura, Ryosuke Yoshida, Kiyohiro Takahasi, Fuyuhiko Inagaki
Publikováno v:
Genes to Cells. 17:159-172
We determined the solution structures of the calmodulin (CaM) isoform from yeast Saccharomyces cerevisiae (yCaM) in the calcium-bound form and in complex with a target peptide using NMR spectroscopy and small-angle X-ray scattering (SAXS). yCaM shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6a40e136a4e81b947c90e31d076c71f
https://doi.org/10.1111/j.1365-2443.2012.01580.x
https://doi.org/10.1111/j.1365-2443.2012.01580.x
Autor:
Mitsutoshi Yoneyama, Takashi Fujita, Reiko Hirai, Kiyohiro Takahasi, Maiko Kageyama, Hiroki Kato, Ryo Narita
Publikováno v:
Biochemical and Biophysical Research Communications. 415:75-81
In virus-infected cells, viral RNA with non-self structural pattern is recognized by DExD/Hbox RNA helicase, RIG-I. Once RIG-I senses viral RNA, it triggers a signaling cascade, resulting in the activation of genes including type I interferon, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cb227e663dae806d0fffc6c8ddc059
https://doi.org/10.1016/j.bbrc.2011.10.015
https://doi.org/10.1016/j.bbrc.2011.10.015
Publikováno v:
Immunological Reviews. 243:91-98
Viral infection results in the generation of non-self RNA species in the cells, which is recognized by retinoic acid inducible gene-I-like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974a4cc5a8db424ea92f7c7f6f1c8400
https://doi.org/10.1111/j.1600-065x.2011.01052.x
https://doi.org/10.1111/j.1600-065x.2011.01052.x
Autor:
Koji Onomoto, Kiyohiro Takahasi, Michael R. Edwards, Ryota Ouda, Hiroki Kato, Mitsutoshi Yoneyama, Takashi Fujita
Publikováno v:
Journal of Biological Chemistry. 286:26210-26219
In mammals, viral infections are detected by innate immune receptors, including Toll-like receptor and retinoic acid inducible gene I (RIG-I)-like receptor (RLR), which activate the type I interferon (IFN) system. IFN essentially activates genes enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2977d5b70b20049d9b47db01a6fb00c8
https://doi.org/10.1074/jbc.m111.229856
https://doi.org/10.1074/jbc.m111.229856