Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kiyohiro Hashimoto"'
Autor:
Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Kiyohiro Hashimoto, Nozomu Sakai, Shinya Asano, Saori Watanabe-Matsumoto, Takeshi Watanabe, Bunnai Saito, Hirokazu Matsumoto, Hikaru Ueno, Ryo Ito, Taro Toyoda
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the saf
Externí odkaz:
https://doaj.org/article/a21dd5df379540a8874afc1118b6fef0
Autor:
David, Kirkland, James, Whitwell, Robert, Smith, Kiyohiro, Hashimoto, Zhiying, Ji, Julia, Kenny, Naoki, Koyama, David P, Lovell, Hans-Jörg, Martus, Krista, Meurer, Daniel, Roberts, Akira, Takeiri, Yoshifumi, Uno, Bas-Jan, van der Leede, Paul, White, Andreas, Zeller
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503503
It is often assumed that genotoxic substances will be detected more easily by using in vitro rather than in vivo genotoxicity tests since higher concentrations, more cytotoxicity and static exposures can be achieved. However, there is a paucity of da
Autor:
Ben Gilby, Maik Schuler, Jennifer Y. Tanir, Shambhu K Roy, Kiyohiro Hashimoto, James Whitwell, Azeddine Elhajouji, Christopher S Farabaugh, David P. Lovell, Yan Li, Mick Fellow
A database of the micronuclei counts was built up for historical negative control data from human lymphocyte in vitro micronuclei tests (MnVit) carried out in 8 laboratories with experience of the method. The mean incidence of micronucleated cells (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3065302df8498969d5b3700a7b28928e
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/110519/1/1-s2.0-S1383571818301578-main.pdf
Autor:
Sawako Kasamoto, Maik Schuler, James Whitwell, Véronique Thybaud, Ozaki Masayasu, Jennifer Y. Tanir, Freddy Van Goethem, Robert Smith, Francesco Marchetti, Martha M. Moore, Joan Christiansen, Leon F. Stankowski, Yan Li, Jin Tanaka, Mick D. Fellows, Kiyohiro Hashimoto, Azeddine Elhajouji, David P. Lovell
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 825
The recent revisions of the Organisation for Economic Co-operation and Development (OECD) genetic toxicology test guidelines emphasize the importance of historical negative controls both for data quality and interpretation. The goal of a HESI Genetic
Autor:
Kiyohiro Hashimoto, Takeshi Todo
Publikováno v:
Mutagenesis. 28:457-464
Micronuclei induced by aneugens are larger than those induced by clastogens in both in vitro and in vivo micronucleus (MN) assays. p53 dysfunction increases the formation of large micronuclei following treatment with aneugens; this study sought to id
Autor:
Jun Nakamura, Hiroyuki Sasanuma, Minoru Takata, Kiyohiro Hashimoto, James A. Swenberg, Shunichi Takeda, Vyom Sharma, Xu Tian
Publikováno v:
Oncotarget
Isopropyl methanesulfonate (IPMS) is the most potent genotoxic compound among methanesulfonic acid esters. The genotoxic potential of alkyl sulfonate esters is believed to be due to their alkylating ability of the O6 position of guanine. Understandin
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 726:21-28
In in vitro micronucleus (MN) assays the sensitivity to MN induction or cytotoxicity can vary depending on the kind of cells employed. This study was conducted to examine the involvement of the p53 function in the different sensitivities between Chin
Publikováno v:
Mutagenesis. 27:287-293
We previously reported that the proportion of large-size micronuclei (MN) can be a reliable parameter to discriminate aneugens from clastogens in the in vitro MN assay using Chinese hamster lung cells. The frequencies of polynuclear (PN) and mitotic
Publikováno v:
Regulatory Toxicology and Pharmacology. 59:28-36
In the OECD Guideline 487, a total of four extended exposure treatment conditions are proposed for the in vitro micronucleus (MNvit) assay in the presence and absence of a cytokinesis block and with or without a recovery period. This guideline also s
Publikováno v:
Toxicology in Vitro. 24:208-216
In the in vitro micronucleus (MN) assay, genotoxic chemicals can be characterized as aneugens and clastogens by the presence and absence of kinetochore protein or centromere regions in the micronuclei, respectively. Aneugens preferentially induce kin