Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kiyoharu Ukai"'
Autor:
Yoshinori Hayashi, Tokiko Shimizu, Kurt von Figura, Christoph Peters, Yasuo Uchiyama, Masato Koike, Jun Yamada, Hiroshi Nakanishi, Takaichi Fukuda, Ryo Yamasaki, Kazunori Mine, Paul Saftig, Kiyoharu Ukai, Jian Zhang
Publikováno v:
Journal of Neurochemistry. 94:680-690
Although of clinical importance, little is known about the mechanism of seizure in neuronal ceroid lipofuscinosis (NCL). In the present study, we have attempted to elucidate the mechanism underlying the seizure of cathepsin D-deficient (CD-/-) mice t
Autor:
Ken Sasaki, Shigeru Kurasaki, Chiharu Hirotani, Yutaka Oki, Tadashi Ohyama, Katsuhiko Ase, Tadashi Okuno, Naomi Doi, Kiyoharu Ukai
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 371:54-60
KP-102 (GHRP-2: pralmorelin) is a synthetic growth hormone releasing peptide (GHRP) that powerfully stimulates the release of GH by acting (i.v.) at both hypothalamic and pituitary sites. Intravenous (i.v.) administration of KP-102 also elicits sligh
Autor:
Yoshinori Hayashi, Hidetoshi Tozaki-Saitoh, Shigehiro Ohdo, Shinichi Kohsaka, Satoru Koyanagi, Kiyoharu Ukai, Hiroshi Nakanishi, Kazuhide Inoue, Ryo Okada, Naoki Kusunose, Zhou Wu
Publikováno v:
Scientific Reports
Microglia are thought to play important roles in the maintenance of neuronal circuitry and the regulation of behavior. We found that the cortical microglia contain an intrinsic molecular clock and exhibit a circadian expression of cathepsin S (CatS),
Publikováno v:
European Journal of Pharmacology. 204:29-34
The effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonists, (+)-MK-801 hydrogen maleate (MK-801) and phencyclidine hydrochloride (PCP), were tested against hypoxia-induced tonic convulsions and hippocampal epileptiform discharges. Sys
Autor:
Shigenori Watanabe, Hiroshi Nakanishi, Osamu Kamata, Terutake Nakagawa, Kenji Yamamoto, Kiyoharu Ukai
Publikováno v:
Brain Research. 532:69-75
Synaptic potentials evoked in the medial amygdala (m-AMG) neurons were studied in in vitro slice preparations obtained from normal and olfactory bulbectomized rats. Local stimulation induced a sequence of responses: a fast EPSP, a fast IPSP and a slo
Autor:
Terutake Nakagawa, Masakazu Imaizumi, Naomi Doi, Osafumi Shimada, Sadayoshi Furuta, Jyo Watanabe, Kiyoharu Ukai
Publikováno v:
Arzneimittel-Forschung. 54(12)
The general pharmacological effects of the hexapeptide KP-102 (D-alanyl-3-(2-naphthyl)-D-alanyl-L-alanyl-L-tryptophyl - D -phenylalanyl - L -lysinamide dihy-drochloride, growth hormone-releasing peptide-2, GHRP-2, pralmorelin, CAS 158861-67-7), which
Publikováno v:
Neurotoxicity research. 3(3)
The effects of sibutramine on central dopaminergic system in rats and mice were examined by neurochemical and behavioral pharmacological methods. Dopamine reuptake inhibition by sibutramine in brain synaptosomes was only 4-5 times stronger than those
Publikováno v:
European journal of pharmacology. 484(2-3)
In order to clarify the mechanism underlying the anti-obesity effects of sibutramine, we examined the effects of sibutramine on extracellular levels of dopamine and 5-hydroxytryptamine (5-HT) through microdialysis in the striatum in unanesthetized an
Autor:
Kazuo Chihara, Genzo Iguchi, Hiroshi Hosoda, Masahiro Murata, Keiji Iida, Kenji Kangawa, Yasuhiko Okimura, Masayasu Kojima, Hidesuke Kaji, Kiyoharu Ukai
Publikováno v:
Life sciences. 72(22)
To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previou
Publikováno v:
Experimental animals. 49(4)
When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decrease