Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Kiyofumi, Asai"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 1, Pp 65-69 (2021)
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) c
Externí odkaz:
https://doaj.org/article/4968c6615d40456fad391e34b64d3d94
Autor:
Naoko Inamura, Momoko Kito, Shinji Go, Soichiro Kishi, Masanori Hosokawa, Kiyofumi Asai, Nobuyuki Takakura, Hirohide Takebayashi, Junko Matsuda, Yasushi Enokido
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 51-62 (2018)
Krabbe disease (KD), or globoid cell leukodystrophy, is an inherited lysosomal storage disease with leukodystrophy caused by a mutation in the galactosylceramidase (GALC) gene. The majority of patients show the early onset form of KD dominated by cer
Externí odkaz:
https://doaj.org/article/d5dde1e035be4af9829f6c011d3604e3
Autor:
Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Shoichi Sasaki, Takahiro Yasui, Kiyofumi Asai, Kazunori Kimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 4, Pp 219-225 (2016)
We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats. First, we ex
Externí odkaz:
https://doaj.org/article/f0a316199f334e41a6a04e6f0167c0ac
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 227-232 (2014)
Abstract.: Upregulation of the Kir2.1 channel during endoplasmic reticulum (ER) stress in t-BBEC117, an immortalized bovine brain endothelial cell line, caused a sustained increase in intracellular Ca2+ concentration ([Ca2+]i) and a facilitation of c
Externí odkaz:
https://doaj.org/article/50a4fc82f6a9469da79de5cd645ddf3d
Autor:
Yoshiaki Suzuki, Hisao Yamamura, Kiyofumi Asai, Yuji Imaizumi, Takahisa Suzuki, Miki Yasumoto
Publikováno v:
Molecular Pharmacology. 98:61-71
The blood-brain barrier (BBB) is essential for the maintenance of homeostasis in the brain. Brain capillary endothelial cells (BCECs) comprise the BBB, and thus a delicate balance between their proliferation and death is required. Although the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7a75eceb2c380ed989fef382098203
https://doi.org/10.1124/mol.119.118844
https://doi.org/10.1124/mol.119.118844
Publikováno v:
Biochemical and Biophysical Research Communications. 523:153-158
Brain capillary endothelial cells (BCECs) form the blood-brain barrier (BBB) and play an essential role in the regulation of its functions. Oxidative stress accumulates excessive reactive oxygen species (ROS) and facilitates the death of BCECs, leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff149217667c806bf4d56101e3719f9
https://doi.org/10.1016/j.bbrc.2019.12.035
https://doi.org/10.1016/j.bbrc.2019.12.035
Autor:
Yuji Joyo, Yohei Kawaguchi, Hiroki Yonezu, Hiroya Senda, Sanshiro Yasuma, Hiroo Shiraga, Masahiro Nozaki, Mineyoshi Aoyama, Kiyofumi Asai, Hideki Murakami, Yuko Waguri-Nagaya
Publikováno v:
Immunologic research. 70(2)
Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities in the pathogenesis of rheumatoid arthritis (RA). The novel oral Janus kinase (JAK) inhibitor baricitinib has demonstrated high efficacy in RA. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee1b68c8b11e70f60b95e87a7ba4bb4
https://pubmed.ncbi.nlm.nih.gov/35014010
https://pubmed.ncbi.nlm.nih.gov/35014010
Autor:
Jin-ichi Ito, Yuko Nagayasu, Kuniko Okumura-Noji, Rui Lu, Tomo Nishida, Yutaka Miura, Kiyofumi Asai, Alireza Kheirollah, Seiichi Nakaya, Shinji Yokoyama
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 9, Pp 2020-2027 (2007)
Fibroblast growth factor-1 (FGF-1) is secreted by astrocytes and stimulates apolipoprotein E (apoE)-HDL biogenesis by an autocrine mechanism to help in recovery from brain injury. In apoE-deficient mouse astrocytes, FGF-1 stimulated cholesterol biosy
Externí odkaz:
https://doaj.org/article/a2e75841e85e49c1885e03a542acc077
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 1, Pp 103-107 (2007)
ATP-receptor (P2Y) stimulation induced sustained Ca2+-entry, which was essential for the enhanced cell-proliferation in t-BBEC117, an immortalized cell-line derived from bovine brain endothelial cells. Application of Ca2+ following store-depletion wi
Externí odkaz:
https://doaj.org/article/a678c5e2b61946cbbcddacbbe2ec096c
Autor:
Masayuki Morikawa, John D. Fryer, Patrick M. Sullivan, Erin A. Christopher, Suzanne E. Wahrle, Ronald B. DeMattos, Mark A. O'Dell, Anne M. Fagan, Hilal A. Lashuel, Thomas Walz, Kiyofumi Asai, David M. Holtzman
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 66-76 (2005)
The apolipoprotein E (apoE) genotype is an important genetic risk factor for Alzheimer's disease (AD). In the central nervous system (CNS), most apoE is produced by astrocytes and is present in unique high-density lipoprotein (HDL)-like particles tha
Externí odkaz:
https://doaj.org/article/214fb0a157034797bffabec2f2d2b9c9