Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kiyoe Ura"'
Autor:
Ayuna Takeishi, Hiroyuki Kogashi, Mizuki Odagiri, Hiroyuki Sasanuma, Shunichi Takeda, Manabu Yasui, Masamitsu Honma, Tetsuya Suzuki, Hiroyuki Kamiya, Kaoru Sugasawa, Kiyoe Ura, Akira Sassa
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244790 (2020)
Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with genomic instability, which is mediated by DNA topoisomerase 1 (Top1) processing of embedded
Externí odkaz:
https://doaj.org/article/d653b045ca4047c8bc158c4aafc822ad
Autor:
Elena Campos-Sanchez, Nerea Deleyto-Seldas, Veronica Dominguez, Enrique Carrillo-de-Santa-Pau, Kiyoe Ura, Pedro P. Rocha, JungHyun Kim, Arafat Aljoufi, Anna Esteve-Codina, Marc Dabad, Marta Gut, Holger Heyn, Yasufumi Kaneda, Keisuke Nimura, Jane A. Skok, Maria Luisa Martinez-Frias, Cesar Cobaleda
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1586-1601 (2017)
Immunodeficiency is one of the most important causes of mortality associated with Wolf-Hirschhorn syndrome (WHS), a severe rare disease originated by a deletion in chromosome 4p. The WHS candidate 1 (WHSC1) gene has been proposed as one of the main g
Externí odkaz:
https://doaj.org/article/574ce904ee724bb8a20ad99efa05c09a
Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 9, Pp 1027-1035 (2015)
WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3. In humans, WHSC1 haploinsufficiency is associated with all known cases of Wolf-Hirschhorn syndrome (WHS). The cardinal feature of WHS i
Externí odkaz:
https://doaj.org/article/582ca89c18484f53a23f06b1441abaf4
Autor:
Andrea J Hartlerode, Yinghua Guan, Anbazhagan Rajendran, Kiyoe Ura, Gunnar Schotta, Anyong Xie, Jagesh V Shah, Ralph Scully
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49211 (2012)
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have
Externí odkaz:
https://doaj.org/article/51153115b6584b1b91bea854d1bd5d6d
Autor:
Tomoko Kawai, Shiori Kinoshita, Yuka Takayama, Eriko Onishi, Hiromi Kamura, Kazuaki Kojima, Hiroki Kikuchi, Miho Terao, Tohru Sugawara, Ohsuke Migita, Masayo Kagami, Tsuyoshi Isojima, Yu Yamaguchi, Keiko Wakui, Hirofumi Ohashi, Kenji Shimizu, Seiji Mizuno, Nobuhiko Okamoto, Yoshimitsu Fukushima, Fumio Takada, Kenjiro Kosaki, Shuji Takada, Hidenori Akutsu, Kiyoe Ura, Kazuhiko Nakabayashi, Kenichiro Hata
PurposeWolf-Hirschhorn syndrome (WHS), a contiguous gene syndrome caused by the hemizygous deletion of the distal short arm of chromosome 4 whereNSD2is, reportedly exhibits specific DNA methylation signatures in peripheral blood cells. However, respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf314c316d110e2bb983466a7a44174
https://doi.org/10.1101/2023.01.06.522834
https://doi.org/10.1101/2023.01.06.522834
Autor:
Kiyoe Ura, Takashi Umehara, Takashi Funatsu, Masatoshi Wakamori, Kohki Okabe, Masahiro Takinoue
Publikováno v:
Nucleic Acids Research
Eukaryotic transcription is epigenetically regulated by chromatin structure and post-translational modifications (PTMs). For example, lysine acetylation in histone H4 is correlated with activation of RNA polymerase I-, II-, and III-driven transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b3f33b91743d745aea277248444996
https://pubmed.ncbi.nlm.nih.gov/33238306
https://pubmed.ncbi.nlm.nih.gov/33238306
Autor:
Hidefumi Suzuki, Hiroyuki Tamashiro, Takeshi Endo, Kazunori Takano, Shinta Saito, Waka Kojima, Hiro Takahashi, Taka-aki Tamura, Ryo Maeda, Noritaka Adachi, Kiyoe Ura
Publikováno v:
Journal of Biological Chemistry. 292:3201-3212
Stress-induced activation of p53 is an essential cellular response to prevent aberrant cell proliferation and cancer development. The ubiquitin ligase MDM2 promotes p53 degradation and limits the duration of p53 activation. It remains unclear, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041fa19b2534983cf1619dd99acf4053
https://doi.org/10.1074/jbc.m116.763318
https://doi.org/10.1074/jbc.m116.763318
Autor:
Hiroyuki Sasanuma, Kaoru Sugasawa, Masamitsu Honma, Manabu Yasui, Shunichi Takeda, Akira Sassa, Ayuna Takeishi, Masataka Tsuda, Megumi Suzuki, Haruto Tada, Kaho Harada, Kiyoe Ura
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
DNA polymerases often incorporate non-canonical nucleotide, i.e., ribonucleoside triphosphates into the genomic DNA. Aberrant accumulation of ribonucleotides in the genome causes various cellular abnormalities. Here, we show the possible role of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67e719d2f6abd3bf8cb5b1e752787c
https://pubmed.ncbi.nlm.nih.gov/31558768
https://pubmed.ncbi.nlm.nih.gov/31558768
Autor:
Yuki Takada-Horisawa, Kiyoe Ura, Jafar Sharif, Kuniko Nakajima, Shin-ichi Tomizawa, Ruken Yaman-Deveci, Yasuyuki Sato, Haruhiko Koseki, Toshio Suda, Akio Yamashita, Masahiro Muto, Kazuyuki Ohbo, Hidetoshi Sone, Shosei Yoshida, Takayuki Shirakawa, Yoshito Kamizato
Publikováno v:
Development. 140:3565-3576
Epigenetic modifications influence gene expression and chromatin remodeling. In embryonic pluripotent stem cells, these epigenetic modifications have been extensively characterized; by contrast, the epigenetic events of tissue-specific stem cells are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf40d28c6c6e826279c10922c27b9451
https://doi.org/10.1242/dev.094045
https://doi.org/10.1242/dev.094045
Autor:
Verónica Domínguez, Holger Heyn, Yasufumi Kaneda, María Luisa Martínez-Frías, Kiyoe Ura, César Cobaleda, Elena Campos-Sanchez, Marc Dabad, Marta Gut, Arafat Aljoufi, Keisuke Nimura, Nerea Deleyto-Seldas, Jung Hyun Kim, Pedro P. Rocha, Anna Esteve-Codina, Jane A. Skok, Enrique Carrillo-de-Santa-Pau
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Cell Reports, Vol 19, Iss 8, Pp 1586-1601 (2017)
instname
Recercat. Dipósit de la Recerca de Catalunya
Cell Reports, Vol 19, Iss 8, Pp 1586-1601 (2017)
Immunodeficiency is one of the most important causes of mortality associated with Wolf-Hirschhorn syndrome (WHS), a severe rare disease originated by a deletion in chromosome 4p. The WHS candidate 1 (WHSC1) gene has been proposed as one of the main g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1306a792a9efb2fd446d3158252f5c09
https://pubmed.ncbi.nlm.nih.gov/28538178
https://pubmed.ncbi.nlm.nih.gov/28538178