Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Kiyo‐Aki Ishii"'
Autor:
Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, Ryogo Shimizu, Souma Yamanaka, Atsushi Abe, Hitoshi Omura, Kazunori Kawaguchi, Hikari Okada, Taro Yamashita, Tomoki Yoshikawa, Kazuhiro Takimoto, Motoko Taharaguchi, Shogo Takatsuka, Yoshitsugu Miyazaki, Toshikatsu Tamai, Yamato Tanabe, Makoto Kurachi, Yasuhiko Yamamoto, Shuichi Kaneko, Kunio Matsumoto, Toshinari Takamura, Masao Honda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The innate antiviral immune response is an important defense against infection. Here, the authors show that leukocyte cell-derived chemotaxin 2 (LECT2) promotes RIG-I-mediated innate immune responses by preventing its degradation, and inhibits lympho
Externí odkaz:
https://doaj.org/article/255dc45f68324700bcce168ab5fc087f
Autor:
Yumie Takeshita, Chisato Teramura, Kyoko Kamoshita, Hiroaki Takayama, Hiromi Nakagawa, Yasufumi Enyama, Kiyo‐Aki Ishii, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Sachie Osada, Yoshiaki Tanaka, Kumpei Tokuyama, Toshinari Takamura
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 3, Pp 532-542 (2022)
ABSTRACT Aim Selenoprotein P (SeP, encoded by SELENOP in humans) is a hepatokine that causes insulin resistance in the liver and skeletal muscle. It was found that polyunsaturated fatty acid eicosapentaenoic acid (EPA) downregulates Selenop expressio
Externí odkaz:
https://doaj.org/article/2291939474354f1ba9a6bcaefcac3fa8
Autor:
Noboru Takata, Kiyo-aki Ishii, Hiroaki Takayama, Mayumi Nagashimada, Kyoko Kamoshita, Takeo Tanaka, Akihiro Kikuchi, Yumie Takeshita, Yukako Matsumoto, Tsuguhito Ota, Yasuhiko Yamamoto, Satoshi Yamagoe, Akihiro Seki, Yoshio Sakai, Shuichi Kaneko, Toshinari Takamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and is upregulated prior to weight gain. The aim of this study was to investigate the si
Externí odkaz:
https://doaj.org/article/e247c50a13e443be9ca0d4e1e98cbdad
Autor:
Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/c28d3d04041647d4bfbe4c3e40bc1e3c
Autor:
Hirobumi Igawa, Akihiro Kikuchi, Hirofumi Misu, Kiyo‐aki Ishii, Shuichi Kaneko, Toshinari Takamura
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 1, Pp 32-42 (2019)
Abstract Aims/Introduction Previous studies have shown that an organism's nutritional status changes the protein levels of insulin receptor substrate 1 (IRS‐1) in a tissue‐specific manner. Although the mechanisms underlying the regulation of IRS
Externí odkaz:
https://doaj.org/article/1016b45993fd434ba2feeb055ead7496
Autor:
Yoshihiro Araki, Hisaki Aiba, Takeshi Yoshida, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Tuan D. Nguyen, Kiyo-aki Ishii, Takayuki Nojima, Satoru Takahashi, Hideki Murakami, Hiroyuki Tsuchiya, Rikinari Hanayama
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Osteosarcoma is the most frequent type of primary bone tumor in children and adolescents, thus care for patients with malignant osteosarcoma is strongly required. The roles of small extracellular vesicles (SEVs) in enhancing metastases have been demo
Externí odkaz:
https://doaj.org/article/3812d90d1848430c9fca73a7958be9a3
Autor:
Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of selenoprotein P are elevated during aging and in people with t
Externí odkaz:
https://doaj.org/article/18c28b5a8a1f42cca014c8cc1b1d9b5e
Autor:
Tatsuhiko Ikeda, Kiyo-aki Ishii, Yuria Saito, Masahiro Miura, Aoi Otagiri, Yasushi Kawakami, Hitoshi Shimano, Hisato Hara, Kazuhiro Takekoshi
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 1, Pp 67-73 (2013)
Sunitinib is an oral multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity that mainly targets vascular endothelial growth factor receptors, and recently, it has been shown to be an active agent for the treatment
Externí odkaz:
https://doaj.org/article/c6cfc70e03d3455793582f01f8afb7fe
Autor:
Kyoko Kamoshita, Kiyo-aki Ishii, Yumiko Tahira, Akihiro Kikuchi, Halimulati Abuduwaili, Natsumi Tajima-Shirasaki, Qifang Li, Hiroaki Takayama, Kunio Matsumoto, Toshinari Takamura
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:5-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29121d3e69554c8ac5bc6248e3071cd
https://doi.org/10.1124/jpet.122.001088
https://doi.org/10.1124/jpet.122.001088
Autor:
Kyoko Kamoshita, Hirohiko Tsugane, Kiyo-Aki Ishii, Hiroaki Takayama, Xingyu Yao, Halimulati Abuduwaili, Ryota Tanida, Yasumasa Taniguchi, Hein Ko Oo, Guzel Gafiyatullina, Shuichi Kaneko, Seiichi Matsugo, Toshinari Takamura
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 322:E556-E568
Selenoprotein P (SeP; encoded by SELENOP in humans, Selenop in rodents) is a hepatokine that is upregulated in the liver of humans with type 2 diabetes. Excess SeP contributes to the onset of insulin resistance and various type 2 diabetes-related com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577cdda0d7c9d434a6d24d0326867d5e
https://doi.org/10.1152/ajpendo.00163.2021
https://doi.org/10.1152/ajpendo.00163.2021