Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates without systemic immune suppression: A pilot study.

Autor: Sremac M; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Luo H; Division of Transplant Surgery and Center of Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of General Surgery, General Hospital of Western Theater Command, Chengdu, China., Deng H; Division of Transplant Surgery and Center of Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA., Parr MFE; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Hutcheson J; ViCapsys, Inc., Athens, Georgia, USA., Verde PS; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Alagpulinsa DA; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Kitzmann JM; Department of Surgery, Institute for Cellular Transplantation, University of Arizona, Tucson, Arizona, USA., Papas KK; Department of Surgery, Institute for Cellular Transplantation, University of Arizona, Tucson, Arizona, USA., Brauns T; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Markmann JF; Division of Transplant Surgery and Center of Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA., Lei J; Division of Transplant Surgery and Center of Transplantation Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA., Poznansky MC; Vaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Publikováno v: Xenotransplantation [Xenotransplantation] 2023 Nov-Dec; Vol. 30 (6), pp. e12826. Date of Electronic Publication: 2023 Sep 15.