Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Kitt Falk Petersen"'
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Background Nonalcoholic fatty liver affects 25% to 30% of the US and European populations; is associated with insulin resistance (IR), type 2 diabetes, and increased cardiovascular risk; and is defined by hepatic triglyceride (HTG) content greater th
Externí odkaz:
https://doaj.org/article/70bbdce028414b128c4cf3dc7bdf4df3
Autor:
Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic flux
Externí odkaz:
https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b
Autor:
João Paulo G. Camporez, Shoichi Kanda, Max C. Petersen, François R. Jornayvaz, Varman T. Samuel, Sanjay Bhanot, Kitt Falk Petersen, Michael J. Jurczak, Gerald I. Shulman
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 526-536 (2015)
ApoA5 has a critical role in the regulation of plasma TG concentrations. In order to determine whether ApoA5 also impacts ectopic lipid deposition in liver and skeletal muscle, as well as tissue insulin sensitivity, we treated mice with an antisense
Externí odkaz:
https://doaj.org/article/378e07a47d21452e8c3cbb1b31db8d9b
Autor:
Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in Equation 30, which was inadvertently introduced during the production process. This has now been corrected in the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/4b6ff0bdb1e94a36bf8769f0be83ad0b
Autor:
Panu K. Luukkonen, Ikki Sakuma, Rafael C. Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K. Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 ( HSD17B13 , rs72613567-A) is associated with a reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e00c6a62d24933271105d69ddf57a566
https://doi.org/10.1073/pnas.2217543120
https://doi.org/10.1073/pnas.2217543120
Autor:
Dongyan Zhang, Yuichi Nozaki, Gerald I. Shulman, Graeme F. Mason, Xian-Man Zhang, Kitt Falk Petersen, Sofie Haedersdal, Varman T. Samuel, Gina M. Butrico, Douglas L. Rothman, Rachel J. Perry, Gary W. Cline, Abudukadier Abulizi, Max C. Petersen, Daniel F. Vatner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hepatic glycogen synthesis plays a critical role in maintaining normal glucose homeostasis; however, the rate-controlling step regulating this process is unknown. Applying metabolic control analysis in vivo, we show that the regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1632ebe3621a1bf0aef3593b54a090f
https://doi.org/10.1073/pnas.1921694117
https://doi.org/10.1073/pnas.1921694117
Autor:
Gary W. Cline, Antti Hakkarainen, Hannele Yki-Järvinen, Xian-Man Zhang, Gerald I. Shulman, Panu K. Luukkonen, Kun Lyu, Sylvie Dufour, Kitt Falk Petersen, Tiina Lehtimäki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Ketogenic diet is an effective treatment for nonalcoholic fatty liver disease (NAFLD). Here, we present evidence that hepatic mitochondrial fluxes and redox state are markedly altered during ketogenic diet-induced reversal of NAFLD in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc8a6857d630bf27bbed4329ee2da42
https://doi.org/10.1073/pnas.1922344117
https://doi.org/10.1073/pnas.1922344117
Autor:
Aviva Rabin-Court, Sylvie Dufour, Ye Zhang, Ali Nasiri, Xian-Man Zhang, Liang Peng, Gary W. Cline, Gina M. Butrico, Leigh Goedeke, Keshia Toussaint, Rachel J. Perry, Gerald I. Shulman, Allison L. Brill, Michael H. Nathanson, Dongyan Zhang, Yongliang Wang, Yuichi Nozaki, Barbara E. Ehrlich, Kitt Falk Petersen, Mateus T. Guerra
Publikováno v:
Nature. 579:279-283
Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes1–3, the mechanisms by which glucagon affects hepatic gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b903c5e6214fd54124f628fa524524c3
https://doi.org/10.1038/s41586-020-2074-6
https://doi.org/10.1038/s41586-020-2074-6
Publikováno v:
The Liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a72381a0cda8049e5d00e6cc2a814db
https://doi.org/10.1002/9781119436812.ch37
https://doi.org/10.1002/9781119436812.ch37
Autor:
Kitt Falk Petersen, Gerald I. Shulman
Publikováno v:
Journal of Hepatology. 77:S714-S715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::276132536028c581dc65d33eac7623d1
https://doi.org/10.1016/s0168-8278(22)01746-9
https://doi.org/10.1016/s0168-8278(22)01746-9