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Thrombin activated Interleukin-1α drives atherogenesis, but also promotes VSMC proliferation and collagen production

Autor: Laura, Burzynski C, Morales-Maldonado, Maria A, Rodgers, Amanda, Kitt, Lauren A, Humphry, Melanie, Figg, Nichola, Bennett, Martin R, Clarke, Murray CH

AIMS: Atherosclerosis is driven by multiple processes across multiple body systems. For example, the innate immune system drives both atherogenesis and plaque rupture via inflammation, while coronary artery-occluding thrombi formed by the coagulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e7a5567b630c3b31201ce6b39f18eb

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The coagulation and immune systems are directly linked through the activation of interleukin-1α by thrombin

Autor: Clarke, Murray, Burzynski, Laura, Humphry, Melanie, Pyrillou, Katerina, Wiggins, Katerina, Chan, Julie, Figg, Nichola, Kitt, Lauren, Summers, Charlotte, Tatham, Kate, Martin, Paul, Bennett, Martin

Publikováno v: Burzynski, L C, Humphry, M, Pyrillou, K, Wiggins, K A, Chan, J N E, Figg, N, Kitt, L L, Summers, C, Tatham, K C, Martin, P B, Bennett, M R & Clarke, M C H 2019, ' The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin ', Immunity, vol. 50, no. 4, pp. 1033-1042.e6 . https://doi.org/10.1016/j.immuni.2019.03.003

Ancient organisms have a combined coagulation and immune system, and although links between inflammation and haemostasis exist in mammals, they are indirect and slower to act. Here we investigated direct links between mammalian immune and coagulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dab063a60dfb7f583970d48df075f3
http://hdl.handle.net/10044/1/68702

Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors.

Autor: Chan, Julie N.E., Humphry, Melanie, Kitt, Lauren, Krzyzanska, Dominika, Filbey, Kara J., Bennett, Martin R., Clarke, Murray C.H.

Publikováno v: European Journal of Immunology; Nov2020, Vol. 50 Issue 11, p1663-1675, 13p