PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells

Autor: Kaya Elisa Witte, Carsten Slotta, Melanie Lütkemeyer, Angelika Kitke, Roland Coras, Matthias Simon, Christian Kaltschmidt, Barbara Kaltschmidt

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)

Abstract A signalling pathway involving PLEKHG5 (guanine exchange factor) for the Ras superfamily member RAB26 to transcription factor NF-κB was discovered in autophagy. PLEKHG5 was reported in glioblastoma multiforme (GBM) and correlates with patie

Externí odkaz: https://doaj.org/article/9ca64becd4b34645835d2d046c52bd05

Targeting Key Signaling Pathways in Glioblastoma Stem Cells for the Development of Efficient Chemo- and Immunotherapy

Autor: Kaltschmidt, Laureen P. Helweg, Jonathan Storm, Kaya E. Witte, Wiebke Schulten, Lennart Wrachtrup, Till Janotte, Angelika Kitke, Johannes F. W. Greiner, Cornelius Knabbe, Barbara Kaltschmidt, Matthias Simon, Christian

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12919

Glioblastoma multiforme (GBM) is the most aggressive and most common malignant brain tumor with poor patient survival despite therapeutic intervention. On the cellular level, GBM comprises a rare population of glioblastoma stem cells (GSCs), driving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b9b945c0e87c8445fb39a00e129a18b0

PLEKHG5/RAB26 signalling regulates expression of the chemotherapy resistance gene MGMT in human glioblastoma

Autor: Witte, KE, Slotta, C, Kitke, A, Greiner, JFW, Coras, R, Mertzlufft, F, Simon, M, Kaltschmidt, B, Kaltschmidt, C

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV183 /20200626/

Objective: Pleckstrin homology containing family member 5 (PLEKHG5) is an exchange factor for the RAS-related protein RAB26 and was described as a target of the tumor necrosis factor α (TNFα)-protective pathway. PLEKHG5-signaling might play a key r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5686b9e9317928cc979fef4ae9e2e1fd