Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kitaw Negash"'
Autor:
Bianca Squillaci, Dung Nguyen, Mohammad Hossain, Clara Andonian, Mally Lev, Kitaw Negash, May Ho, Courtney Tiffany, Jill L. Pirhalla, Cathy L. Chen, Igor Goljer, Clive Felgate, Ernest Schubert
Publikováno v:
Xenobiotica. 46:683-702
1. GSK2140944 is a novel bacterial topoisomerase inhibitor in development for the treatment of bacterial infections. The metabolism and disposition in healthy human subjects was investigated. 2. Six male subjects received [(14)C] GSK2140944 orally (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cdaedb2a7b066d33ebe7c9913253aa
https://doi.org/10.3109/00498254.2015.1112933
https://doi.org/10.3109/00498254.2015.1112933
Autor:
Emile P. Chen, Mohammed M. Dar, Yanwen Qian, Peter D. Gorycki, Yanli Deng, A. Benjamin Suttle, Kitaw Negash, May Y. K. Ho, Caroline Sychterz, David A. Bershas
Publikováno v:
Xenobiotica. 43:443-453
1. Pazopanib (Votrient) is an oral tyrosine kinase inhibitor that was recently approved for the treatment of renal cell carcinoma and soft tissue sarcoma. 2. In this two-part study, we investigated the metabolism, disposition of [(14)C]pazopanib, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afb5d9e737fb0795d5057fc96e8b8b3
https://doi.org/10.3109/00498254.2012.734642
https://doi.org/10.3109/00498254.2012.734642
Publikováno v:
Pharmacology Research & Perspectives
The ability to explain distribution patterns from drug physicochemical properties and binding characteristics has been explored for more than 200 compounds by interrogating data from quantitative whole body autoradiography studies (QWBA). These in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cd32780be7b3b16a755fbdb9d63b74
https://pubmed.ncbi.nlm.nih.gov/26516585
https://pubmed.ncbi.nlm.nih.gov/26516585
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 43:1183-1191
The preparation of two radioiodinated analogs of the epidermal growth factor receptor tyrosine kinase (EGFrTK) inhibitor PD153035 (4-(3'-bromoanilino)-6,7-dimethoxyquinazoline) are reported herein. The two analogs, 4-(3'-[ 125 I]iodoanilino)-6,7-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc23563ea12af3b8a250f63c9eb7b1fc
https://doi.org/10.1002/1099-1344(20001030)43:12<1183::aid-jlcr405>3.0.co
https://doi.org/10.1002/1099-1344(20001030)43:12<1183::aid-jlcr405>3.0.co
Autor:
David J. Riese, Sarah M. Slavik, Stephanie L. Coffing, Jennifer L. Vanderpoel, Andrew B. Morris, John K. Lim, Michele Y. Ono, Scott E. Taylor, Kitaw Negash, Henry F. VanBrocklin, Darren L. Hom, Stephen M. Hanrahan
Publikováno v:
Journal of medicinal chemistry. 48(23)
The epidermal growth factor receptor (EGFR), a long-standing drug development target, is also a desirable target for imaging. Sixteen dialkoxyquinazoline analogues, suitable for labeling with positron-emitting isotopes, have been synthesized and eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139965c01f7b52370def249f382361ee
https://pubmed.ncbi.nlm.nih.gov/16279804
https://pubmed.ncbi.nlm.nih.gov/16279804
Autor:
Negash, Kitaw1 (AUTHOR) kitaw.2.negash@GSK.com, Andonian, Clara1 (AUTHOR), Felgate, Clive2 (AUTHOR), Chen, Cathy1 (AUTHOR), Goljer, Igor1 (AUTHOR), Squillaci, Bianca2 (AUTHOR), Nguyen, Dung1 (AUTHOR), Pirhalla, Jill1 (AUTHOR), Lev, Mally1 (AUTHOR), Schubert, Ernest1 (AUTHOR), Tiffany, Courtney3 (AUTHOR), Hossain, Mohammad4 (AUTHOR), Ho, May1 (AUTHOR)
Publikováno v:
Xenobiotica. Aug2016, Vol. 46 Issue 8, p683-702. 20p.
Autor:
Harrell, Andrew W.1, Sychterz, Caroline2, Ho, May Y.2, Weber, Andrew2, Valko, Klara3, Negash, Kitaw2
Publikováno v:
Pharmacology Research & Perspectives. Oct2015, Vol. 3 Issue 5, p1-N.PAG. 12p.
Autor:
Deng, Yanli1 (AUTHOR) yanli.2.deng@gsk.com, Sychterz, Caroline1 (AUTHOR), Suttle, A. Benjamin2 (AUTHOR), Dar, Mohammed M.3 (AUTHOR), Bershas, David1 (AUTHOR), Negash, Kitaw1 (AUTHOR), Qian, Yanwen1 (AUTHOR), Chen, Emile P.1 (AUTHOR), Gorycki, Peter D.1 (AUTHOR), Ho, May Y. K.1 (AUTHOR)
Publikováno v:
Xenobiotica. May2013, Vol. 43 Issue 5, p443-453. 11p.
Publikováno v:
Drug Metabolism Reviews. Nov2009 Supplement 3, Vol. 41, p7-186. 180p. 11 Diagrams, 6 Charts.