Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kit-Yi Leung"'
Autor:
Haneesha Mohan, Jessica Nguyen, Ben MacKenzie, Audrey Yee, Evelyn Yukino Laurette, Tanvi Sanghvi, Oscar Tejada, Valeriya Dontsova, Kit-Yi Leung, Cameron Goddard, Taylor De Young, John G. Sled, Nicholas D.E. Greene, Andrew J. Copp, Lena Serghides
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104762- (2023)
Summary: Background: Dolutegravir (DTG) is a recommended first-line regimen for all people with Human Immunodeficiency Virus (HIV) infection. Initial findings from Botswana, a country with no folate fortification program, showed an elevated prevalenc
Externí odkaz:
https://doaj.org/article/7e048acef5e94323b030a6a4ee465c56
Autor:
Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely u
Externí odkaz:
https://doaj.org/article/5d363a763a9c431a9c93d4a8e3417ea0
Autor:
Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D. E. Greene, André E. X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.
Externí odkaz:
https://doaj.org/article/497f6a1f580e4f1db58b61849bc60df7
Autor:
Haneesha Mohan, Monica Guzman Lenis, Evelyn Y. Laurette, Oscar Tejada, Tanvi Sanghvi, Kit-Yi Leung, Lindsay S. Cahill, John G. Sled, Paul Delgado-Olguín, Nicholas D.E. Greene, Andrew J. Copp, Lena Serghides
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103167- (2021)
Background: Dolutegravir (DTG) is a preferred regimen for all people with HIV including pregnant women, but its effects on the fetus are not fully understood. Periconceptional exposure to DTG has been associated with increased rates of neural tube de
Externí odkaz:
https://doaj.org/article/b67b5396b8d6461f9d661ea55cd7e4fb
Autor:
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine. Mutation of AMT or GLDC, encoding the GCS components aminomethyltransferase and glycine deca
Externí odkaz:
https://doaj.org/article/37c5049f4a084bb58c2472ba1b4ac0ed
Autor:
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S. Gross, Andrew J. Copp, Nicholas D.E. Greene
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1795-1808 (2017)
Summary: Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and,
Externí odkaz:
https://doaj.org/article/abf6f1dd135c4b04b5be5c03e75400aa
Autor:
Sonia Sudiwala, Alexandra Palmer, Valentina Massa, Alan J. Burns, Louisa P. E. Dunlevy, Sandra C. P. de Castro, Dawn Savery, Kit-Yi Leung, Andrew J. Copp, Nicholas D. E. Greene
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 11 (2019)
Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most common birth defects worldwide, but their underlying genetic and cellular causes are not well understood. Some NTDs are preventable by supplemental folic acid. How
Externí odkaz:
https://doaj.org/article/5ea44426f8104b8dacbf5a7faf4dee8b
Autor:
Lang, Marie B., Kit-Yi Leung, Greene, Nicholas D. E., Malone, Kerri M., Saginc, Gaye, Randi, Anna M., Kiprianos, Allan, Maughan, Robert T., Pericleous, Charis, Mason, Justin C.
Publikováno v:
Frontiers in Immunology; 2023, p1-16, 16p
Autor:
Eleanor Weston, Faith Pangilinan, Simon Eaton, Michael Orford, Kit-Yi Leung, Andrew J Copp, James L Mills, Anne M Molloy, Lawrence C Brody, Nicholas DE Greene
Publikováno v:
The Journal of nutrition.
Myo-inositol (MI) is incorporated into numerous biomolecules, including phosphoinositides and inositol phosphates. Disturbance of inositol availability or metabolism is associated with various disorders, including neurological conditions and cancers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7603a2e0c700aa7dfaecea329e0792b5
https://pubmed.ncbi.nlm.nih.gov/36055793
https://pubmed.ncbi.nlm.nih.gov/36055793
Autor:
Alexios A Panoutsopoulos, Zachary Schaaf, Lyle Henderson, Ralph Green, Shailaja Racherla, Angelo Harlan De Crescenzo, Kit Yi Leung, Konstantinos Zarbalis, Nicholas D. E. Greene, Lyvin Tat
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991), vol 31, iss 1
Cerebral Cortex (New York, NY)
Cerebral Cortex (New York, NY)
Folate is an essential micronutrient required for both cellular proliferation through de novo nucleotide synthesis and epigenetic regulation of gene expression through methylation. This dual requirement places a particular demand on folate availabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e14792b5324d2485743b57e6bafff
https://doi.org/10.1093/cercor/bhaa248
https://doi.org/10.1093/cercor/bhaa248