Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Kit-Kay Mak"'
Autor:
Ranjeet Ajit Bapat, Kit-Kay Mak, Mallikarjuna Rao Pichika, Jia Chern Pang, Seow Liang Lin, Suan Phaik Khoo, Umer Daood
Publikováno v:
BMC Oral Health, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Aims and objectives To analyze anti-MMP mode of action of Quaternary Ammonium Silane (QAS, codenamed as k21) by binding onto specific MMP site using computational molecular simulation and Anti-Sortase A (SrtA) mode of action by binding onto
Externí odkaz:
https://doaj.org/article/358cabd2a1924f7898c29f2f2ca0b730
Autor:
Jestin Chellian, Kit-Kay Mak, Dinesh Kumar Chellappan, Purushotham Krishnappa, Mallikarjuna Rao Pichika
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The antidiabetic effects of quercetin and metformin are well known. However, their synergistic effect in reversing the symptoms of diabetes-induced endothelial dysfunction remains unknown. In this study, we have investigated their synergisti
Externí odkaz:
https://doaj.org/article/5f81b93e93af4cf1bf22ea92339c3497
Autor:
Kit‐Kay Mak, Zhang Shiming, Dr. Ola Epemolu, Prof. Dr. Albena T. Dinkova‐Kostova, Dr. Geoffrey Wells, Dr. Irina G. Gazaryan, Dr. Raghavendra Sakirolla, Prof. Dr. Zulkefeli Mohd, Prof. Dr. Mallikarjuna Rao Pichika
Publikováno v:
ChemistryOpen, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene. Eighteen compounds were synthesised and confirmed their NRF2 activ
Externí odkaz:
https://doaj.org/article/3b58c0e2150c48848d2a62f4f7dd5ec1
Autor:
Kit-Kay Mak, Shiming Zhang, Jestin Chellian, Zulkefeli Mohd, Ola Epemolu, Albena T. Dinkova-Kostova, Madhu Katyayani Balijepalli, Mallikarjuna Rao Pichika
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 595 (2023)
Our previous studies have reported the effect of swietenine (a major bioactive component of Swietenia macrophylla seeds) in reversing and potentiating the effect of metformin in hyperglycemia and hyperlipidaemia in diabetic rats. Moreover, we reporte
Externí odkaz:
https://doaj.org/article/15fd1e664fdd4628866da7349dda3c74
Autor:
Kit-Kay Mak, Zhang Shiming, Raghavendra Sakirolla, Madhu Katyayani Balijepalli, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 475 (2023)
6-shogaol is a natural and the most potent bioactive vanilloid in dried Zingiber officinale rhizomes. Many scientific studies have reported the diverse biological activities of 6-shogaol. However, the major drawback of 6-shogaol is its instability at
Externí odkaz:
https://doaj.org/article/d71bcd610d884a009bf2b3695b938067
Autor:
Zhang Shiming, Kit-Kay Mak, Madhu Katyayani Balijepalli, Srikumar Chakravarthi, Mallikarjuna Rao Pichika
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111576- (2021)
Diabetes mellitus or type-2 diabetes, commonly referred as diabetes, is a metabolic disorder that results in high blood sugar level. Despite the availability of several antidiabetic drugs in the market, they still do not adequately regulate blood sug
Externí odkaz:
https://doaj.org/article/6cbfe41fda6c40e0a1d76fb5e9b52556
Autor:
Kit-Kay Mak, Zhang Shiming, Jun Sheng Low, Madhu Katyayani Balijepalli, Raghavendra Sakirolla, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
Publikováno v:
Molecules, Vol 27, Iss 15, p 4992 (2022)
Auranamide and patriscabratine are amides from Melastoma malabathricum (L.) Smith. Their anti-inflammatory activity and nuclear factor erythroid 2-related factor 2 (NRF2) activation ability were evaluated using Escherichia coli lipopolysaccharide (LP
Externí odkaz:
https://doaj.org/article/05a9b0ad31114fada5e673e8ecf57823
Autor:
Murugesh Kandasamy, Kit-Kay Mak, Thangaraj Devadoss, Punniyakoti Veeraveedu Thanikachalam, Raghavendra Sakirolla, Hira Choudhury, Mallikarjuna Rao Pichika
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-10 (2019)
Abstract Background The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repressive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, as well as maintenanc
Externí odkaz:
https://doaj.org/article/9046a3eddcdf45398e8e274ef8e5e434
Autor:
Kit-Kay Mak, Zhang Shiming, Madhu Katyayani Balijepalli, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
Publikováno v:
Phytomedicine Plus, Vol 1, Iss 1, Pp 100018- (2021)
Background: Swietenia macrophylla seeds possess diverse biological activities in which inflammation is the primary cause, and swietenine is the main tetranortriterpenoid present. Purpose: The purpose of the study is to investigate the molecular mecha
Externí odkaz:
https://doaj.org/article/f07182f86aa545c1847d569235f6754d
Autor:
Shiming Zhang, Xuefang Kou, Hui Zhao, Kit-Kay Mak, Madhu Katyayani Balijepalli, Mallikarjuna Rao Pichika
Publikováno v:
Molecules, Vol 27, Iss 3, p 775 (2022)
Zingiber officinale var. rubrum (red ginger) is widely used in traditional medicine in Asia. Unlike other gingers, it is not used as a spice in cuisines. To date, a total of 169 chemical constituents have been reported from red ginger. The constituen
Externí odkaz:
https://doaj.org/article/02352fa95dad49bf8f33570cb31a98eb