Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Kit oncogene"'
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 932 (2023)
Acute myeloid leukemia (AML) is a leading blood cancer subtype that can be caused by 27 gene mutations. Previous studies have explored potential vaccine and drug treatments against AML, but many were proven immunologically insignificant. Here, we tar
Externí odkaz:
https://doaj.org/article/37f8b8728a37423692a196adb19a50d5
Akademický článek
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Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 932
Acute myeloid leukemia (AML) is a leading blood cancer subtype that can be caused by 27 gene mutations. Previous studies have explored potential vaccine and drug treatments against AML, but many were proven immunologically insignificant. Here, we tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0550b5e0e726bd675e900ca09ad3d4ac
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
J Chem Theory Comput
G-quadruplexes (GQs) are highly ordered nucleic acid structures that play fundamental roles in regulating gene expression and maintaining genomic stability. GQs are topologically diverse and enriched in promoter sequences of growth regulatory genes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96f232bfb64c2607f392140369bb1b0
https://doi.org/10.1021/acs.jctc.0c00191
https://doi.org/10.1021/acs.jctc.0c00191
Publikováno v:
Journal of Pathology of Nepal, Vol 1, Iss 1, Pp 41-44 (2011)
Background: Mutation of the C-KIT oncogene is the central event in gastrointestinal stromal tumors which are the most common mesenchymal tumors arising from the tubular gastrointestinal tract. Materials and Methods: A study was conducted in Patan hos
Externí odkaz:
https://doaj.org/article/8301a413010d405289de84cebff09717
Autor:
Matthieu Roulleaux Dugage, Jonathan C. Trent, Stéphane Champiat, Robin L. Jones, Sarah Dumont
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Gastrointestinal stromal tumors (GISTs) are a subtype of soft tissue sarcoma (STS), and have become a concept of oncogenic addiction and targeted therapies.The large majority of these tumors develop after a mutation in KIT or platelet derived growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0286cd7a18234346d996776b97650d
http://europepmc.org/articles/PMC8417712
http://europepmc.org/articles/PMC8417712
Autor:
Nauman M. Javed, Jason L. Hornick, Ewa Sicinska, Bradley E. Bernstein, Prafulla C. Gokhale, Benjamin K. Eschle, George D. Demetri, Esmat Hegazi, Matthew L. Hemming, Daniel R. Tarjan, Chandrajit P. Raut, Yotam Drier, Sarah J. Shareef, William A. Flavahan, Sarah E. Johnstone
Publikováno v:
Nature
Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1–3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e025a723c36f280f5610b300e74df6
https://doi.org/10.1038/s41586-019-1668-3
https://doi.org/10.1038/s41586-019-1668-3
Autor:
Aigul R. Venina, Aglaya G. Iyevleva, Lev V. Demidov, Grigory A. Yanus, Evgeny N. Imyanitov, Kristina V. Orlova, Svetlana N. Aleksakhina
Publikováno v:
Case Reports in Oncology. 12:109-112
Approximately 15% of acral and mucous melanomas carry activating mutations in KIT oncogene. There is a diversity of spectrum of KIT mutations, with some of them rendering tumors responsive to imatinib, while others being imatinib-resistant or not stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523b6055646d2500a0bcd617a737d54f
https://doi.org/10.1159/000495782
https://doi.org/10.1159/000495782
Autor:
Luca Nardo, Mauro Dacasto, Claudia Adriana Marrano, Riccardo Rigo, Domenico Salerno, Enrico Buglione, Francesco Mantegazza, Claudia Sissi, Valeria Cassina, Guglielmo Vesco
Publikováno v:
Nucleic Acids Research
G-quadruplexes (G4s) are tetrahelical DNA structures stabilized by four guanines paired via Hoogsteen hydrogen bonds into quartets. While their presence within eukaryotic DNA is known to play a key role in regulatory processes, their functional mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13493f89fe8a225cb1220522aac2bfee
https://pubmed.ncbi.nlm.nih.gov/33849064
https://pubmed.ncbi.nlm.nih.gov/33849064