Výsledky vyhledávání - "Kit Yee Tsang"

Synthesis and Evaluation of Imidazo[1,2‐a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors

Autor: James M. J. Dickson, Swarna A. Gamage, Julie Ann Spicer, Kit Yee Tsang, Woo-Jeong Lee, Gordon W. Rewcastle, William A. Denny, Patrick D. O'Connor, Peter R. Shepherd, Jack U. Flanagan

Publikováno v: Chemistry – An Asian Journal. 14:1249-1261

Using a scaffold-hopping approach, imidazo[1,2-a]pyridine analogues of the ZSTK474 (benzimidazole) class of phosphatidylinositol 3-kinase (PI3K) inhibitors have been synthesized for biological evaluation. Compounds were prepared using a heteroaryl He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d02b66b6177669f4bf49dfe52fc5d01
https://doi.org/10.1002/asia.201801762

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Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

Autor: Stephen M. F. Jamieson, Anna C. Giddens, Woo-Jeong Lee, Jackie D. Kendall, Swarna A. Gamage, Kit Yee Tsang, William A. Denny, Jack U. Flanagan, Bruce C. Baguley, Peter R. Shepherd, Gordon W. Rewcastle, Christina M. Buchanan

Publikováno v: Bioorganicmedicinal chemistry. 25(20)

Replacement of one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 (1) with sulfonamide containing substituents produced a new class of active and potent PI3Kα inhibitors. Solubility issues prevented all but th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586e21c61b59f67fbeb9382c0e06258e
https://pubmed.ncbi.nlm.nih.gov/28958845

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Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: variation of the central linker group

Autor: William A. Denny, Gordon W. Rewcastle, Raphaël Frédérick, Peter R. Shepherd, Andrew J. Marshall, Kit Yee Tsang, Maruta Boyd, Mindy Chao, Christina M. Buchanan, Anna C. Giddens, Bruce C. Baguley, Claire Chaussade, Woo-Jeong Lee, Claire L. Lill, Shuqiao Yu, Jack U. Flanagan, Sharada Kolekar, Jackie D. Kendall, Alisha Malik

Publikováno v: MedChemComm, Vol. 5, no.1, p. 41 [1-6] (2014)

As part of our investigation into the pyrazolo[1,5-a]pyridines as novel PI3K inhibitors, we report a range of analogues where the central linker portion of the molecule was varied while retaining the pyrazolo[1,5-a] pyridine and arylsulfonyl or arylc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7efef4b8d2678ce5198f3be7180cf30
https://doi.org/10.1039/c3md00221g

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Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors

Autor: Shuqiao Yu, Elaine S. Marshall, Gordon W. Rewcastle, Christina M. Buchanan, Kit Yee Tsang, Stephen M. F. Jamieson, Peter R. Shepherd, William A. Denny, Woo-Jeong Lee, Claire L. Lill, Anna C. Giddens, Alisha Malik, Mindy Chao, Bruce C. Baguley, Jackie D. Kendall, Claire Chaussade, Sharada Kolekar

Publikováno v: Bioorganicmedicinal chemistry letters. 27(2)

As part of our investigation into pyrazolo[1,5-a]pyridines as novel p110α selective PI3 kinase inhibitors, we report a range of analogues with improved aqueous solubility by the addition of a basic amine. The compounds demonstrated comparable p110α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1765decdddb96900a7fd603a3fd159
https://pubmed.ncbi.nlm.nih.gov/27923617

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Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Publikováno v: Bioorganic & Medicinal Chemistry. 20:58-68

Structure-activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and replacement of the sulfonyl both gave a loss of p110α selectivity, with the exception of an N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b37468a52699793d2442ac9302f5c1
https://doi.org/10.1016/j.bmc.2011.11.031

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An Efficient Formal Synthesis of the Human Telomerase Inhibitor (±)-γ-Rubromycin

Autor: Kit Yee Tsang, Margaret A. Brimble, Dominea C. K. Rathwell, Sung-Hyun Yang

Publikováno v: Angewandte Chemie International Edition. 48:7996-8000

(1, Scheme 1), the prototypical member of astructurally related family of antibiotics known as therubromycins, consists of a densely oxygenated naphthazarinring and an isocoumarin moiety linked through a uniquearomatic 5,6-spiroketal ring system (Sch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe43c0e474c97fae6d6a81a8d842914
https://doi.org/10.1002/anie.200903316

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Synthesis of aromatic spiroacetals related to γ-rubromycin based on a 3H-spiro[1-benzofuran-2,2′-chromane] skeleton

Autor: Margaret A. Brimble, Kit Yee Tsang

Publikováno v: Tetrahedron. 63:6015-6034

The synthesis of a series of aromatic 5,6-benzannelated and naphthyl-benzannelated spiroacetals related to the spiroacetal unit present in the quinonoid antibiotic γ-rubromycin is reported. The key steps include the use of Sonogashira coupling to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8154d45ce2c8d3a1513fafeb2a7d8ead
https://doi.org/10.1016/j.tet.2007.02.033

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A facile synthesis of fused aromatic spiroacetals based on the 3,4,3′,4′-tetrahydro-2,2′-spirobis(2H-1-benzopyran) skeleton

Autor: Margaret A. Brimble, Michael Trzoss, Kit Yee Tsang, Christopher L. Flowers

Publikováno v: Tetrahedron. 62:5883-5896

The facile synthesis of a series of aromatic 6,6-spiroacetals based on the parent 3,4,3′,4′-tetrahydro-2,2′-spirobis(2H-1-benzopyran) heterocyclic system is reported. Key steps included the use of a Sonogashira coupling for the synthesis of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d580b870bf598e1a774b2dee7f640022
https://doi.org/10.1016/j.tet.2006.04.026

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