Zobrazeno 1 - 10
of 571
pro vyhledávání: '"Kit S Lam"'
Autor:
Michelle Hu, Ruiwu Liu, Noemi Castro, Liliana Loza Sanchez, Lapamas Rueankham, Julie A. Learn, Ruiqi Huang, Kit S. Lam, Kermit L. Carraway
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have the capacity to target tumor cell populations resistant to currently employed therapeutic agents. Howe
Externí odkaz:
https://doaj.org/article/e2c9d3c858cc4cc5b0a5666d7202c03c
Autor:
Yuhsien Lai, Xuesong Wu, Zhuoyu Jiang, Yifei Fang, Xiuting Liu, Dan Hong, Yanyun Jiang, Guozhen Tan, Shiqi Tang, Siyao Lu, David Wei, Sam T. Hwang, Kit S. Lam, Liangchun Wang, Yanyu Huang, Zhenrui Shi
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 83-95 (2024)
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as
Externí odkaz:
https://doaj.org/article/d2630ead11fe4a0e992129147a05d852
Autor:
Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kung
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70910 (2013)
Etk is a non-receptor tyrosine kinase, which provides a strong survival signal in human prostate cancer cells. Src, another tyrosine kinase that cross-activates with Etk, has been shown to play an important role in prostate cancer metastasis. Herein,
Externí odkaz:
https://doaj.org/article/847de7c6ffd142fb90d6021c6ca3066d
Autor:
Nicholas J Kenyon, Jennifer M Bratt, Joyce Lee, Juntao Luo, Lisa M Franzi, Amir A Zeki, Kit S Lam
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77730 (2013)
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previ
Externí odkaz:
https://doaj.org/article/ef08926ab4f3462d9e243771f1ec55f8
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55044 (2013)
MicroRNAs (miRNAs) are non-coding small RNAs that have cell type and cell context-dependent expression and function. To study miRNAs at single-cell resolution, we have developed a novel microfluidic approach, where flow fluorescent in situ hybridizat
Externí odkaz:
https://doaj.org/article/cc120508ae6f40199dea407521a8c19d
Autor:
Allison L Zwingenberger, Michael S Kent, Ruiwu Liu, David L Kukis, Erik R Wisner, Sally J DeNardo, Sandra L Taylor, Xiucui Chen, Kit S Lam
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34404 (2012)
Theranostic agents are critical for improving the diagnosis and treatment of non-Hodgkin Lymphoma (NHL). The peptidomimetic LLP2A is a novel peptide receptor radiotherapy candidate for treating NHL that expresses the activated α4β1 integrin. Tumor-
Externí odkaz:
https://doaj.org/article/73123107f93440b89c262b35608cb26b
Autor:
Dake Hao, Jonathan Lin, Ruiwu Liu, Christopher Pivetti, Kaeli Yamashiro, Linda M. Schutzman, Junichiro Sageshima, Mimmie Kwong, Nataliya Bahatyrevich, Diana L. Farmer, Misty D. Humphries, Kit S. Lam, Alyssa Panitch, Aijun Wang
Publikováno v:
Bioactive Materials, Vol 28, Iss , Pp 467-479 (2023)
Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent funct
Externí odkaz:
https://doaj.org/article/a998f809726e4772bf64c10097549356
Autor:
Yongheng Wang, Weidi Zhang, Yi Wu, Chuyuan Qu, Hongru Hu, Teresa Lee, Siyu Lin, Jiawei Zhang, Kit S. Lam, Aijun Wang
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102259- (2023)
Summary: Conventional approaches for screening anticancer drugs rely on chemical reactions, which are time consuming, labor intensive, and costly. Here, we present a protocol for label-free and high-throughput assessment of drug efficacy using a visi
Externí odkaz:
https://doaj.org/article/821ee57fdef2423691857b5b4fec1748
Autor:
Hengyue Song, Kewa Gao, Dake Hao, Andrew Li, Ruiwu Liu, Bryan Anggito, Boyan Yin, Qianyu Jin, Vanessa Dartora, Kit S. Lam, Lucas R. Smith, Alyssa Panitch, Jianda Zhou, Diana L. Farmer, Aijun Wang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The lack of vascularization associated with deep burns delays the construction of wound beds, increases the risks of infection, and leads to the formation of hypertrophic scars or disfigurement. To address this challenge, we have fabricated a multi-f
Externí odkaz:
https://doaj.org/article/6044fdbd2b2949d9945fc9e6112cbd08
Autor:
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Publikováno v:
Bioactive Materials, Vol 10, Iss , Pp 460-473 (2022)
Diabetic ischemic wound treatment remains a critical clinical challenge. Neovascularization plays a significant role in wound healing during all stages of the tissue repair process. Strategies that enhance angiogenesis and neovascularization and impr
Externí odkaz:
https://doaj.org/article/e0cf9bdd9cf540b48f856c8d765dacfb