Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory

Autor: Barral, S., Bird, T., Goate, A., Farlow, M.R., Diaz-Arrastia, R., Bennett, D.A., Graff-Radford, N., Boeve, B.F., Sweet, R.A., Stern, Y., Wilson, R.S., Foroud, T., Ott, J., Mayeux, R., Green, Robert, Kowall, Neil, Farrer, Lindsay, Williamson, Jennifer, Santana, Vincent, Schmechel, Donald, Gaskel, Peter, Ghetti, Bernardino, Farlow, Martin R., Faber, Kelley, Prentice, Heather, Horner, Kelly, Growdon, John H., Blacker, Deborah, Tanzi, Rudolph E., Hyman, Bradley T., Boeve, Bradley, Kuntz, Karen, Norgaard, Lindsay, Larson, Nathan, Kistler, Dana, Parfitt, Francine, Haddow, Jenny, Silverman, Jeremy, Beeri, Michal Schnaider, Sano, Mary, Wang, Joy, Lally, Rachel, Johnson, Nancy, Mesulam, Marcel, Weintraub, Sandra, Bigio, Eileen, Kaye, Jeffery, Kramer, Patricia, Payne-Murphy, Jessica, Bennett, David, Jacobs, Holli, Chang, Jeen-Soo, Arends, Danielle, Harrell, Lindy, Bartzokis, George, Cummings, Jeffery, Lu, Po H., Toland, Usha, Smith, Charles, Brickhouse, Alise, Trojanowski, John, Van Deerlin, Vivianna, McCarty Wood, Elisabeth, DeKosky, Steven, Sweet, Robert, Weamer, Elise, Chui, Helena, Varpetian, Arousiak, Diaz-Arrastia, Ramon, Rosenberg, Roger, Davis, Barbara, Bird, Thomas, Schellenberg, Gerard D., Raskind, Murray, Rumbaugh, Malia, Nickel, Kate, Goate, Alison, Morris, John, Norton, Joanne, Levitch, Denise, Grant, Betsy, Coats, Mary, Levey, Allen, Rosen, Ami, Anosike, Ezinna

Objective: Several genome-wide association studies (GWAS) have associated variants in lateonset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bfec74d40e908860672c9efe67723c
https://europepmc.org/articles/PMC3345618/